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Gch1 GTP cyclohydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 14528, updated on 8-May-2016
Official Symbol
Gch1provided by MGI
Official Full Name
GTP cyclohydrolase 1provided by MGI
Primary source
MGI:MGI:95675
See related
Ensembl:ENSMUSG00000037580
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gch; GTPCH; GTP-CH
Orthologs
Location:
14 24.6 cM; 14 C2-3
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (47153895..47189402, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47773570..47809077, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4 Neighboring gene microRNA 378c Neighboring gene predicted gene 10371 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene suppressor of cytokine signaling 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTP cyclohydrolase I activity IDA
Inferred from Direct Assay
more info
PubMed 
GTP cyclohydrolase I activity ISO
Inferred from Sequence Orthology
more info
 
GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
dihydrobiopterin metabolic process ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process controlling posture ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
pteridine-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of lung blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to pain ISO
Inferred from Sequence Orthology
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
tetrahydrobiopterin biosynthetic process IC
Inferred by Curator
more info
PubMed 
tetrahydrobiopterin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
GTP cyclohydrolase 1
Names
GTP cyclohydrolase I
GTP-CH-I
NP_032128.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008102.3NP_032128.1  GTP cyclohydrolase 1 precursor

    See identical proteins and their annotated locations for NP_032128.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154589, AC159006
    Consensus CDS
    CCDS26984.1
    UniProtKB/Swiss-Prot
    Q05915
    UniProtKB/TrEMBL
    Q3U7P6
    Related
    ENSMUSP00000087405, ENSMUST00000089959
    Conserved Domains (2) summary
    pfam01543
    Location:451
    HCV_capsid; Hepatitis C virus capsid protein
    cd00642
    Location:57241
    GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    47153895..47189402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    43334771..43370387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)