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Gas6 growth arrest specific 6 [ Mus musculus (house mouse) ]

Gene ID: 14456, updated on 28-May-2016
Official Symbol
Gas6provided by MGI
Official Full Name
growth arrest specific 6provided by MGI
Primary source
MGI:MGI:95660
See related
Ensembl:ENSMUSG00000031451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gas-6
Orthologs
Location:
8 A1.1; 8 6.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (13465374..13494535, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13465374..13494535, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene transmembrane protein 255B Neighboring gene predicted gene, 38614 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene RAS p21 protein activator 3 Neighboring gene predicted gene, 34795

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
binding, bridging ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
receptor agonist activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor agonist activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vitamin K ISO
Inferred from Sequence Orthology
more info
 
enzyme linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fusion of virus membrane with host plasma membrane ISO
Inferred from Sequence Orthology
more info
 
hematopoietic stem cell migration to bone marrow ISO
Inferred from Sequence Orthology
more info
 
macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein targeting to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
viral genome replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
growth arrest-specific protein 6
Names
AXL receptor tyrosine kinase ligand
GAS 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019521.2NP_062394.2  growth arrest-specific protein 6 precursor

    See identical proteins and their annotated locations for NP_062394.2

    Status: VALIDATED

    Source sequence(s)
    AI482478, AK086187, CJ062651, X59846
    Consensus CDS
    CCDS40232.1
    UniProtKB/Swiss-Prot
    Q61592
    Related
    ENSMUSP00000033828, ENSMUST00000033828
    Conserved Domains (4) summary
    smart00069
    Location:2690
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:194234
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:295447
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam14670
    Location:244274
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    13465374..13494535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    13633535..13662710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)