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    LAYN layilin [ Homo sapiens ]

    Gene ID: 143903, updated on 11-May-2012
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    Summary

    Official Symbol
    LAYNprovided by HGNC
    Official Full Name
    layilinprovided by HGNC
    Primary source
    HGNC:29471
    Locus tag
    UNQ208/PRO234
    See related
    Ensembl:ENSG00000204381; HPRD:17299; Vega:OTTHUMG00000166721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ30977; FLJ31092
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    Genomic context

    Location :
    11q23.1
    Sequence :
    Chromosome: 11; NC_000011.9 (111411233..111431788)
    See LAYN in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728196 Neighboring gene chromosome 11 open reading frame 88 Neighboring gene microRNA 34c Neighboring gene salt-inducible kinase 2 Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Bono P, et al. Exp Cell Res, 2005 Aug 1. PMID 15913605.
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:126823 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    layilin
    Names
    layilin
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258390.1 → NP_001245319.1  layilin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK055539, AK296231, AY358554, DA608521

    2. NM_001258391.1 → NP_001245320.1  layilin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two internal exons and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK055539, AK296231, DA608521, DB006476

    3. NM_178834.4 → NP_849156.1  layilin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK055539, AK296231, DA608521
      Consensus CDS
      CCDS31676.1
      UniProtKB/Swiss-Prot
      Q6UX15
      Related
      ENSP00000364764, OTTHUMP00000234053, ENST00000375614, OTTHUMT00000391186
      Conserved Domains (1) summary
      cd03595
      Location:30 – 178
      Blast Score: 772
      CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      111411233..111431788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      107335428..107355989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP002008.5 (151750..172305) None
    genomic CH471065.1 EAW67143.1
      EAW67144.1
      EAW67145.1
    mRNA AK055539.1 BAB70946.1
    mRNA AK055654.1 BAB70978.1
    mRNA AK293317.1 BAG56836.1
    mRNA AK296231.1 BAG58952.1
    mRNA AK298165.1 BAG60438.1
    mRNA AY358554.1 AAQ88918.1
    mRNA BC025407.1 AAH25407.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UX15.1 GenPept UniProtKB/Swiss-Prot:Q6UX15
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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