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    CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [ Homo sapiens ]

    Gene ID: 1439, updated on 19-May-2012
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    Summary

    Official Symbol
    CSF2RBprovided by HGNC
    Official Full Name
    colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)provided by HGNC
    Primary source
    HGNC:2436
    Locus tag
    CITF22-45C1.4
    See related
    Ensembl:ENSG00000100368; HPRD:00739; MIM:138981; Vega:OTTHUMG00000150546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD131; IL3RB; IL5RB; SMDP5; CDw131
    Summary
    The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    22q13.1
    Sequence :
    Chromosome: 22; NC_000022.10 (37309675..37336481)
    See CSF2RB in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene FLJ90680 protein Neighboring gene neutrophil cytosolic factor 4, 40kDa Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) pseudogene 1 Neighboring gene uncharacterized protein FLJ39582-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling. Lei JT, et al. J Biol Chem, 2011 Nov 18. PMID 21965659.
    2. Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population. Chen P, et al. World J Biol Psychiatry, 2011 Apr. PMID 21247258.
    3. Down-regulating the expression of IL-3Rβ interfered with the proliferation, not differentiation in NB4 cells. Li X, et al. Int J Hematol, 2011 Jan. PMID 21207215.
    4. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations. Suzuki T, et al. Eur Respir J, 2011 Jan. PMID 21205713.
    5. [Expression change of IL-3 receptor system in all-trans retinoic acid induced differentiation of NB4 cells]. Wu Y, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010 Dec. PMID 21176354.

    See all (85) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling.
      Title: Three lysine residues in the common β chain of the interleukin-5 receptor are required for Janus kinase (JAK)-dependent receptor ubiquitination, endocytosis, and signaling.
    2. Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells.
      Title: [Expression change of IL-3 receptor system in all-trans retinoic acid induced differentiation of NB4 cells].
    3. Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils
      Title: Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
    4. The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population.
      Title: Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population.
    5. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report]
      Title: Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations.
    6. the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation.
      Title: Down-regulating the expression of IL-3Rβ interfered with the proliferation, not differentiation in NB4 cells.
    7. The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration.
      Title: Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis.
    8. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling
      Title: The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms.
      Title: Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.
    Submit: New GeneRIF Correction See all (25)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Pulmonary alveolar proteinosis

    Surfactant metabolism dysfunction, pulmonary, 5

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000386.1 NP_002349.1 MAD2L1    BIND  PubMed MAD2 interacts with CSF2RB. This interaction was modelled on a demonstrated interaction between mouse MAD2 and human CSFR2B. 
    NP_000386.1     BIND  PubMed IL5-IL5R-alpha complex interacts with IL5R-beta. 
    P32927 Q9NSE2 CISH    HPRD  PubMed  
    P32927 P04141 CSF2    HPRD  PubMed  
    P32927 P15509 CSF2RA    HPRD  PubMed  
    P32927 P32927 CSF2RB    HPRD  PubMed  
    P32927 P19235 EPOR    HPRD  PubMed  
    P32927 P07332 FES    HPRD  PubMed  
    P32927 P06241 FYN    HPRD  PubMed  
    P32927 P63244 GNB2L1    HPRD  PubMed  
    P32927 P08631 HCK    HPRD  PubMed  
    P32927 P08700 IL3    HPRD  PubMed  
    P32927 P26951 IL3RA    HPRD  PubMed  
    P32927 Q01344 IL5RA    HPRD  PubMed  
    P32927 P23458 JAK1    HPRD  PubMed  
    P32927 O60674 JAK2    HPRD  PubMed  
    P32927 P35968 KDR    HPRD  PubMed  
    P32927 P10721 KIT    HPRD  PubMed  
    P32927 P06239 LCK    HPRD  PubMed  
    P32927 P07948 LYN    HPRD  PubMed  
    P32927 Q13257 MAD2L1    HPRD  PubMed  
    P32927 P05771 PRKCB    HPRD  PubMed  
    P32927 Q06124 PTPN11    HPRD  PubMed  
    P32927 P29350 PTPN6    HPRD  PubMed  
    P32927 P29353 SHC1    HPRD  PubMed  
    P32927 P42224 STAT1    HPRD  PubMed  
    P32927 P40763 STAT3    HPRD  PubMed  
    P32927 P43405 SYK    HPRD  PubMed  
    P32927 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:107826 BioGRID:107826 CSF2RB    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107826 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107826 BioGRID:109777 IL3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107826 BioGRID:109782 IL5RA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107826 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107826 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107826 BioGRID:110245 LYN    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:107826 BioGRID:110260 MAD2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107826 BioGRID:111565 PRKCB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107826 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107826 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107826 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107826 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107826 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
      Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
    • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to interleukin-3 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    contributes_to interleukin-5 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular response to interleukin-3 TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interleukin-5-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    respiratory gaseous exchange TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    granulocyte macrophage colony-stimulating factor receptor complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    cytokine receptor common subunit beta
    Names
    cytokine receptor common subunit beta
    GM-CSF/IL-3/IL-5 receptor common beta-chain
    GM-CSF/IL-3/IL-5 receptor common beta subunit
    colony-stimulating factor-2 receptor, beta, low-affinity
    interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008040.1 RefSeqGene

      Range
      5001..31807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000395.2 → NP_000386.1  cytokine receptor common subunit beta precursor

      Status: REVIEWED

      Source sequence(s)
      AL133392, BC070085
      Consensus CDS
      CCDS13936.1
      UniProtKB/Swiss-Prot
      P32927
      UniProtKB/TrEMBL
      Q6NSJ8
      Related
      ENSP00000384053, OTTHUMP00000197801, ENST00000403662, OTTHUMT00000318854
      Conserved Domains (2) summary
      cl00065
      Location:335 – 428
      Blast Score: 104
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl12153
      Location:245 – 338
      Blast Score: 94
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      37309675..37336481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      20271284..20300485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL008637.1 CAI17999.1
      CAQ10745.1
    genomic AL133392.1 (100..5334) None
    genomic CH471095.1 EAW60125.1
      EAW60126.1
    mRNA AK302993.1 BAG64130.1
    mRNA BC070085.1 AAH70085.1
    mRNA CR456428.1 CAG30314.1
    mRNA M59941.1 AAA18171.1
    other-genetic CU012989.1 CAK54420.1
    other-genetic CU013277.1 CAK54719.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32927.2 GenPept UniProtKB/Swiss-Prot:P32927
    Q6NSJ8 GenPept UniProtKB/TrEMBL:Q6NSJ8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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