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CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Homo sapiens (human) ]

Gene ID: 1438, updated on 21-Mar-2015
Official Symbol
CSF2RAprovided by HGNC
Official Full Name
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)provided by HGNC
Primary source
HGNC:HGNC:2435
See related
Ensembl:ENSG00000198223; HPRD:02381; MIM:306250; MIM:425000; Vega:OTTHUMG00000012533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha
Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Orthologs
See CSF2RA in MapViewer
Location:
Xp22.32 and Yp11.3
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (1268800..1325078)
107 current GRCh38.p2 (GCF_000001405.28) Y NC_000024.10 (1268800..1325078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1387693..1428828)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1337693..1378828)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene cytokine receptor-like factor 2 Neighboring gene microRNA 3690 Neighboring gene uncharacterized LOC101928055 Neighboring gene interleukin 3 receptor, alpha (low affinity) Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene cytokine receptor-like factor 2 Neighboring gene microRNA 3690 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor, alpha (low affinity) Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of colony stimulating factor 2 receptor, alpha subunit (CSF2RA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
    G beta:gamma signalling through PI3Kgamma, organism-specific biosystemPI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predomi...
  • G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
    G-protein beta:gamma signalling, organism-specific biosystemThe classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known tha...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3848, MGC4838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Names
granulocyte-macrophage colony-stimulating factor receptor subunit alpha
CD116 antigen
GM-CSF receptor alpha subunit
GMCSFR-alpha
GMR-alpha
colony stimulating factor 2 receptor alpha subunit
granulocyte-macrophage colony-stimulating factor receptor alpha chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012280.1 RefSeqGene

    Range
    5001..46136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_186

mRNA and Protein(s)

  1. NM_001161529.1NP_001155001.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See proteins identical to NP_001155001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same isoform a, which is membrane-bound.
    Source sequence(s)
    AL833597, BC002635, BC071835, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000416437, ENST00000432318
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_001161530.1NP_001155002.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

    See proteins identical to NP_001155002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an additional in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (f) is the longest, and has identical N- and C-termini compared to isoform a.
    Source sequence(s)
    AL833597, DQ841258, X17648
    Consensus CDS
    CCDS55359.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000394227, ENST00000417535
    Conserved Domains (3) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam13900
    Location:320353
    GVQW; Putative binding domain
  3. NM_001161531.1NP_001155003.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

    See proteins identical to NP_001155003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 3' exon compared to variant 1. The resulting isoform (g) is longer and has different C-terminus compared to isoform a.
    Source sequence(s)
    BI868829, M64445
    Consensus CDS
    CCDS55360.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370920, OTTHUMP00000014508, ENST00000381509, OTTHUMT00000035017
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. NM_001161532.1NP_001155004.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h

    See proteins identical to NP_001155004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks a 5' UTR exon and a coding exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (h) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK301395, AL833597, BC002635, BI868829, X17648
    Consensus CDS
    CCDS55361.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000440491, ENST00000501036
    Conserved Domains (1) summary
    pfam09240
    Location:182
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. NM_006140.4NP_006131.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See proteins identical to NP_006131.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 7 encode the same isoform (a), which is membrane-bound.
    Source sequence(s)
    AL833597, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370935, OTTHUMP00000014504, ENST00000381524, OTTHUMT00000035013
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. NM_172245.2NP_758448.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See proteins identical to NP_758448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same isoform a, which is membrane-bound.
    Source sequence(s)
    AL833597, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370940, OTTHUMP00000014917, ENST00000381529, OTTHUMT00000035797
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  7. NM_172246.2NP_758449.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two coding exons in the 3' region, which causes a frameshift, compared to variant 1. The resulting isoform (b), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, BI868829, L29349
    Consensus CDS
    CCDS35190.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000347606, OTTHUMP00000014507, ENST00000355432, OTTHUMT00000035016
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  8. NM_172247.2NP_758450.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    See proteins identical to NP_758450.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a coding exon in the 3' region, which causes a frameshift, compared to variant 1. The resulting isoform (c), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, M64445, M73832, X17648
    Consensus CDS
    CCDS35192.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370911, OTTHUMP00000014918, ENST00000381500, OTTHUMT00000035798
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  9. NM_172249.2NP_758452.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform e precursor

    See proteins identical to NP_758452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks four coding exons, which causes a frameshift, compared to variant 1. The resulting isoform (e), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, BI868829, U93096
    Consensus CDS
    CCDS35193.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000348058, OTTHUMP00000014505, ENST00000355805, OTTHUMT00000035014
    Conserved Domains (1) summary
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RNA

  1. NR_027760.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks a coding exon compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
    Source sequence(s)
    AL833597, BI868829, L29348

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    1268800..1325078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p2 Primary Assembly

    Range
    1268800..1325078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545624.1XP_011543926.1  

    See proteins identical to XP_011543926.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. XM_011545629.1XP_011543931.1  

    See proteins identical to XP_011543931.1

    Conserved Domains (2) summary
    smart00060
    Location:176254
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:76171
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  3. XM_011545621.1XP_011543923.1  

    See proteins identical to XP_011543923.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. XM_011545628.1XP_011543930.1  

    See proteins identical to XP_011543930.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. XM_011545622.1XP_011543924.1  

    See proteins identical to XP_011543924.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. XM_011545627.1XP_011543929.1  

    See proteins identical to XP_011543929.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  7. XM_011545623.1XP_011543925.1  

    See proteins identical to XP_011543925.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  8. XM_011545620.1XP_011543922.1  

    See proteins identical to XP_011543922.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  9. XM_011545619.1XP_011543921.1  

    See proteins identical to XP_011543921.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  10. XM_011545626.1XP_011543928.1  

    See proteins identical to XP_011543928.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  11. XM_011545618.1XP_011543920.1  

    See proteins identical to XP_011543920.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  12. XM_011545625.1XP_011543927.1  

    See proteins identical to XP_011543927.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  13. XM_011546171.1XP_011544473.1  

    See proteins identical to XP_011544473.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  14. XM_011546176.1XP_011544478.1  

    See proteins identical to XP_011544478.1

    Conserved Domains (2) summary
    smart00060
    Location:176254
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:76171
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  15. XM_011546168.1XP_011544470.1  

    See proteins identical to XP_011544470.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  16. XM_011546175.1XP_011544477.1  

    See proteins identical to XP_011544477.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  17. XM_011546169.1XP_011544471.1  

    See proteins identical to XP_011544471.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  18. XM_011546174.1XP_011544476.1  

    See proteins identical to XP_011544476.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  19. XM_011546170.1XP_011544472.1  

    See proteins identical to XP_011544472.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  20. XM_011546167.1XP_011544469.1  

    See proteins identical to XP_011544469.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  21. XM_011546166.1XP_011544468.1  

    See proteins identical to XP_011544468.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  22. XM_011546173.1XP_011544475.1  

    See proteins identical to XP_011544475.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  23. XM_011546165.1XP_011544467.1  

    See proteins identical to XP_011544467.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  24. XM_011546172.1XP_011544474.1  

    See proteins identical to XP_011544474.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    1418017..1458211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172248.1: Suppressed sequence

    Description
    NM_172248.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.