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CSF2RA colony stimulating factor 2 receptor alpha subunit [ Homo sapiens (human) ]

Gene ID: 1438, updated on 7-Feb-2016
Official Symbol
CSF2RAprovided by HGNC
Official Full Name
colony stimulating factor 2 receptor alpha subunitprovided by HGNC
Primary source
HGNC:HGNC:2435
See related
Ensembl:ENSG00000198223; HPRD:02381; MIM:306250; MIM:425000; Vega:OTTHUMG00000012533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha
Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Orthologs
See CSF2RA in Epigenomics, MapViewer
Location:
Xp22.32 and Yp11.3
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (1268800..1325078)
107 current GRCh38.p2 (GCF_000001405.28) Y NC_000024.10 (1268800..1325078)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1387693..1428828)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1337693..1378828)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene cytokine receptor-like factor 2 Neighboring gene microRNA 3690 Neighboring gene uncharacterized LOC101928055 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6-like Neighboring gene cytokine receptor-like factor 2 Neighboring gene microRNA 3690 Neighboring gene uncharacterized LOC101928032 Neighboring gene interleukin 3 receptor subunit alpha Neighboring gene serine/arginine repetitive matrix protein 1-like Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of colony stimulating factor 2 receptor, alpha subunit (CSF2RA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

  • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
    ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4), organism-specific biosystem (from REACTOME)
    Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4), organism-specific biosystemSurfactant catabolism by alveolar macrophages plays a small but critical part in surfactant recycling and metabolism. Upon ligand binding, granulocyte-macrophage colony-stimulating factor receptor (G...
  • Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5), organism-specific biosystem (from REACTOME)
    Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5), organism-specific biosystemSurfactant catabolism by alveolar macrophages plays a small but critical part in surfactant recycling and metabolism. Upon ligand binding, granulocyte-macrophage colony-stimulating factor receptor (G...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with surfactant metabolism, organism-specific biosystem (from REACTOME)
    Diseases associated with surfactant metabolism, organism-specific biosystemThe reactions annotated here describe genetic defects in genes regulating surfactant homeostasis which are associated with severe acute and chronic lung diseases in newborns and older infants (Whitse...
  • Diseases of metabolism, organism-specific biosystem (from REACTOME)
    Diseases of metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • Downstream signaling of activated FGFR1, organism-specific biosystem (from REACTOME)
    Downstream signaling of activated FGFR1, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • Downstream signaling of activated FGFR2, organism-specific biosystem (from REACTOME)
    Downstream signaling of activated FGFR2, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • Downstream signaling of activated FGFR3, organism-specific biosystem (from REACTOME)
    Downstream signaling of activated FGFR3, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • Downstream signaling of activated FGFR4, organism-specific biosystem (from REACTOME)
    Downstream signaling of activated FGFR4, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
  • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
    FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
  • FRS-mediated FGFR1 signaling, organism-specific biosystem (from REACTOME)
    FRS-mediated FGFR1 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
  • FRS-mediated FGFR2 signaling, organism-specific biosystem (from REACTOME)
    FRS-mediated FGFR2 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
  • FRS-mediated FGFR3 signaling, organism-specific biosystem (from REACTOME)
    FRS-mediated FGFR3 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
  • FRS-mediated FGFR4 signaling, organism-specific biosystem (from REACTOME)
    FRS-mediated FGFR4 signaling, organism-specific biosystemThe FRS family of scaffolding adaptor proteins has two members, FRS2 (also known as FRS2 alpha) and FRS3 (also known as FRS2beta or SNT-2). Activation of FGFR tyrosine kinase allows FRS proteins to ...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
    Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
  • G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
    G beta:gamma signalling through PI3Kgamma, organism-specific biosystemPI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predomi...
  • G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
    G-protein beta:gamma signalling, organism-specific biosystemThe classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known tha...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
  • GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
  • GRB2 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    GRB2 events in ERBB2 signaling, organism-specific biosystemERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. ...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
    MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
    Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
  • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
    RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
  • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
  • SHC1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in ERBB2 signaling, organism-specific biosystemAll ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphory...
  • SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in ERBB4 signaling, organism-specific biosystemAll splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound t...
  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
    SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
    Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
    Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
    Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
    Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
    Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
  • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
    Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3848, MGC4838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
granulocyte colony-stimulating factor binding IEA
Inferred from Electronic Annotation
more info
 
granulocyte colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Names
CD116 antigen
GM-CSF receptor alpha subunit
GMCSFR-alpha
GMR-alpha
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
granulocyte-macrophage colony-stimulating factor receptor alpha chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012280.1 RefSeqGene

    Range
    5001..46136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_186

mRNA and Protein(s)

  1. NM_001161529.1NP_001155001.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_001155001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same isoform a, which is membrane-bound.
    Source sequence(s)
    AL833597, BC002635, BC071835, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000416437, ENST00000432318
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_001161530.1NP_001155002.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform f precursor

    See identical proteins and their annotated locations for NP_001155002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an additional in-frame coding exon in the 3' region compared to variant 1. The resulting isoform (f) is the longest, and has identical N- and C-termini compared to isoform a.
    Source sequence(s)
    AL833597, DQ841258, X17648
    Consensus CDS
    CCDS55359.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000394227, ENST00000417535
    Conserved Domains (3) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam13900
    Location:320353
    GVQW; Putative binding domain
  3. NM_001161531.1NP_001155003.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform g precursor

    See identical proteins and their annotated locations for NP_001155003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 3' exon compared to variant 1. The resulting isoform (g) is longer and has different C-terminus compared to isoform a.
    Source sequence(s)
    BI868829, M64445
    Consensus CDS
    CCDS55360.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370920, OTTHUMP00000014508, ENST00000381509, OTTHUMT00000035017
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. NM_001161532.1NP_001155004.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h

    See identical proteins and their annotated locations for NP_001155004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks a 5' UTR exon and a coding exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (h) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AK301395, AL833597, BC002635, BI868829, X17648
    Consensus CDS
    CCDS55361.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000440491, ENST00000501036
    Conserved Domains (1) summary
    pfam09240
    Location:182
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. NM_006140.4NP_006131.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_006131.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 7 encode the same isoform (a), which is membrane-bound.
    Source sequence(s)
    AL833597, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370935, OTTHUMP00000014504, ENST00000381524, OTTHUMT00000035013
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. NM_172245.2NP_758448.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform a precursor

    See identical proteins and their annotated locations for NP_758448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 7 encode the same isoform a, which is membrane-bound.
    Source sequence(s)
    AL833597, BI868829, X17648
    Consensus CDS
    CCDS35191.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370940, OTTHUMP00000014917, ENST00000381529, OTTHUMT00000035797
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  7. NM_172246.2NP_758449.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two coding exons in the 3' region, which causes a frameshift, compared to variant 1. The resulting isoform (b), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, BI868829, L29349
    Consensus CDS
    CCDS35190.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000347606, OTTHUMP00000014507, ENST00000355432, OTTHUMT00000035016
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  8. NM_172247.2NP_758450.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform c precursor

    See identical proteins and their annotated locations for NP_758450.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a coding exon in the 3' region, which causes a frameshift, compared to variant 1. The resulting isoform (c), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, M64445, M73832, X17648
    Consensus CDS
    CCDS35192.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000370911, OTTHUMP00000014918, ENST00000381500, OTTHUMT00000035798
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  9. NM_172249.2NP_758452.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform e precursor

    See identical proteins and their annotated locations for NP_758452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks four coding exons, which causes a frameshift, compared to variant 1. The resulting isoform (e), which is likely soluble, is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL833597, BI868829, U93096
    Consensus CDS
    CCDS35193.1
    UniProtKB/Swiss-Prot
    P15509
    Related
    ENSP00000348058, OTTHUMP00000014505, ENST00000355805, OTTHUMT00000035014
    Conserved Domains (1) summary
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RNA

  1. NR_027760.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks a coding exon compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
    Source sequence(s)
    AL833597, BI868829, L29348
    Related
    ENST00000486791, OTTHUMT00000035015

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p2 Primary Assembly

    Range
    1268800..1325078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    1268800..1325078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546171.1XP_011544473.1  

    See identical proteins and their annotated locations for XP_011544473.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. XM_011546176.1XP_011544478.1  

    See identical proteins and their annotated locations for XP_011544478.1

    Conserved Domains (2) summary
    smart00060
    Location:176254
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:76171
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  3. XM_011546168.1XP_011544470.1  

    See identical proteins and their annotated locations for XP_011544470.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. XM_011546175.1XP_011544477.1  

    See identical proteins and their annotated locations for XP_011544477.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. XM_011546169.1XP_011544471.1  

    See identical proteins and their annotated locations for XP_011544471.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. XM_011546174.1XP_011544476.1  

    See identical proteins and their annotated locations for XP_011544476.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  7. XM_011546170.1XP_011544472.1  

    See identical proteins and their annotated locations for XP_011544472.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  8. XM_011546167.1XP_011544469.1  

    See identical proteins and their annotated locations for XP_011544469.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  9. XM_011546166.1XP_011544468.1  

    See identical proteins and their annotated locations for XP_011544468.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  10. XM_011546173.1XP_011544475.1  

    See identical proteins and their annotated locations for XP_011544475.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  11. XM_011546165.1XP_011544467.1  

    See identical proteins and their annotated locations for XP_011544467.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  12. XM_011546172.1XP_011544474.1  

    See identical proteins and their annotated locations for XP_011544474.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  13. XM_011545624.1XP_011543926.1  

    See identical proteins and their annotated locations for XP_011543926.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  14. XM_011545629.1XP_011543931.1  

    See identical proteins and their annotated locations for XP_011543931.1

    Conserved Domains (2) summary
    smart00060
    Location:176254
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:76171
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  15. XM_011545621.1XP_011543923.1  

    See identical proteins and their annotated locations for XP_011543923.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  16. XM_011545628.1XP_011543930.1  

    See identical proteins and their annotated locations for XP_011543930.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  17. XM_011545622.1XP_011543924.1  

    See identical proteins and their annotated locations for XP_011543924.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  18. XM_011545627.1XP_011543929.1  

    See identical proteins and their annotated locations for XP_011543929.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  19. XM_011545623.1XP_011543925.1  

    See identical proteins and their annotated locations for XP_011543925.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  20. XM_011545620.1XP_011543922.1  

    See identical proteins and their annotated locations for XP_011543922.1

    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  21. XM_011545619.1XP_011543921.1  

    See identical proteins and their annotated locations for XP_011543921.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  22. XM_011545626.1XP_011543928.1  

    See identical proteins and their annotated locations for XP_011543928.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  23. XM_011545618.1XP_011543920.1  

    See identical proteins and their annotated locations for XP_011543920.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  24. XM_011545625.1XP_011543927.1  

    See identical proteins and their annotated locations for XP_011543927.1

    UniProtKB/Swiss-Prot
    P15509
    Conserved Domains (2) summary
    smart00060
    Location:220298
    FN3; Fibronectin type 3 domain
    pfam09240
    Location:120215
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    1418017..1458211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172248.1: Suppressed sequence

    Description
    NM_172248.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.