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Brd2 bromodomain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 14312, updated on 28-May-2016
Official Symbol
Brd2provided by MGI
Official Full Name
bromodomain containing 2provided by MGI
Primary source
MGI:MGI:99495
See related
Ensembl:ENSMUSG00000024335 Vega:OTTMUSG00000017279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; AW228947; mKIAA4005; D17H6S113E
Orthologs
Location:
17 B1; 17 17.98 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (34112019..34122607, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34248964..34258692, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC051537 Neighboring gene histocompatibility 2, P region alpha locus Neighboring gene histocompatibility 2, O region alpha locus Neighboring gene histocompatibility 2, class II, locus DMa Neighboring gene predicted gene, 31142 Neighboring gene histocompatibility 2, class II, locus Mb2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4005

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
bromodomain-containing protein 2
Names
female sterile homeotic-related gene 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204973.1NP_001191902.1  bromodomain-containing protein 2

    See identical proteins and their annotated locations for NP_001191902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK168525, BY244178, CB527269, CO040867
    Consensus CDS
    CCDS28641.1
    UniProtKB/Swiss-Prot
    Q7JJ13
    UniProtKB/TrEMBL
    B2RS09
    Related
    ENSMUSP00000025193, OTTMUSP00000018831, ENSMUST00000025193, OTTMUST00000041870
    Conserved Domains (2) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
  2. NM_010238.3NP_034368.2  bromodomain-containing protein 2

    See identical proteins and their annotated locations for NP_034368.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variant 2.
    Source sequence(s)
    AK158970, CB246848, CO040867
    Consensus CDS
    CCDS28641.1
    UniProtKB/Swiss-Prot
    Q7JJ13
    UniProtKB/TrEMBL
    B2RS09
    Related
    ENSMUSP00000109880, OTTMUSP00000018852, ENSMUST00000114242, OTTMUST00000041915
    Conserved Domains (2) summary
    cd05497
    Location:73179
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:348449
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

RNA

  1. NR_037970.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK147918, BC046809, BM947875
    Related
    ENSMUST00000154232, OTTMUST00000041916

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    34112019..34122607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523658.2XP_006523721.1  

    See identical proteins and their annotated locations for XP_006523721.1

    UniProtKB/Swiss-Prot
    Q7JJ13
    Conserved Domains (2) summary
    cd05497
    Location:27133
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:302403
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

RNA

  1. XR_385282.2 RNA Sequence

Reference GRCm38.p3 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p3 129X1/SvJ

    Range
    360954..371542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525302.2XP_006525365.1  

    See identical proteins and their annotated locations for XP_006525365.1

    UniProtKB/Swiss-Prot
    Q7JJ13
    Conserved Domains (2) summary
    cd05497
    Location:27133
    Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
    cd05498
    Location:302403
    Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

RNA

  1. XR_385930.2 RNA Sequence

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    422823..433395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_390251.2 RNA Sequence

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    422934..433506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_390049.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    36864043..36874631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025387.2: Suppressed sequence

    Description
    NM_001025387.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.