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Tlr3 toll-like receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 142980, updated on 28-May-2016
Official Symbol
Tlr3provided by MGI
Official Full Name
toll-like receptor 3provided by MGI
Primary source
MGI:MGI:2156367
See related
Ensembl:ENSMUSG00000031639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI957183
Orthologs
Location:
8; 8 B2
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (45395665..45411949, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (46481019..46495893, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene family with sequence similarity 149, member A Neighboring gene sorbin and SH3 domain containing 2 Neighboring gene predicted gene, 30759 Neighboring gene predicted gene 16351

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
    Toll Like Receptor signaling, organism-specific biosystem
    Toll Like Receptor signaling
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Trafficking and processing of endosomal TLR, organism-specific biosystem (from REACTOME)
    Trafficking and processing of endosomal TLR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to virus TAS
Traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
microglial cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-alpha biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type III interferon production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of dendritic cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
response to dsRNA ISO
Inferred from Sequence Orthology
more info
 
response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_126166.4NP_569054.2  toll-like receptor 3 precursor

    See identical proteins and their annotated locations for NP_569054.2

    Status: PROVISIONAL

    Source sequence(s)
    AC116861, AC120003
    Consensus CDS
    CCDS22278.1
    UniProtKB/Swiss-Prot
    Q99MB1
    Related
    ENSMUSP00000034056, ENSMUST00000034056
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    45395665..45411949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509279.2XP_006509342.1  

    See identical proteins and their annotated locations for XP_006509342.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  2. XM_011242174.1XP_011240476.1  

    See identical proteins and their annotated locations for XP_011240476.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Related
    ENSMUSP00000126556, ENSMUST00000167106
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  3. XM_006509280.2XP_006509343.1  

    See identical proteins and their annotated locations for XP_006509343.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  4. XM_006509282.2XP_006509345.1  

    See identical proteins and their annotated locations for XP_006509345.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_006509281.2XP_006509344.1  

    See identical proteins and their annotated locations for XP_006509344.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  6. XM_006509283.2XP_006509346.1  

    See identical proteins and their annotated locations for XP_006509346.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]
  7. XM_006509278.2XP_006509341.1  

    See identical proteins and their annotated locations for XP_006509341.1

    UniProtKB/Swiss-Prot
    Q99MB1
    Conserved Domains (7) summary
    smart00082
    Location:646698
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:100319
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:759897
    TIR; TIR domain
    pfam12799
    Location:508546
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:275330
    LRR_8; Leucine rich repeat
    sd00031
    Location:589610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277300
    LRR_RI; leucine-rich repeat [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    48083156..48098074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)