Fos FBJ osteosarcoma oncogene [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Fosprovided by MGI
Official Full Name: FBJ osteosarcoma oncogeneprovided by MGI
Primary source: MGI:95574
See related: Ensembl:ENSMUSG00000021250; Vega:OTTMUSG00000019764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cFos; c-fos; D12Rfj1

Genomic context

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Location :: 12 D2; 12 39.7 cM

Sequence :: Chromosome: 12; NC_000078.6 (85473901..85477269)

See Fos in Epigenomics, MapViewer

Chromosome 12 - NC_000078.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-kappaB and induction of c-Fos and NFATc1.
Title: Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-κB.
Data suggest that miR-181a attenuates ox-LDL-stimulated immune inflammation responses by targeting c-Fos in dendritic cells.
Title: microRNA-181a represses ox-LDL-stimulated inflammatory response in dendritic cell by targeting c-Fos.
hypothalamic c-Fos activation is regulated by daily scheduled high fat meals in mice
Title: Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation.
Fos expression is markedly altered in the Mecp2-null brain compared with controls. It was increased in the nucleus tractus solitarius, but reduced in limbic & subcortical structures.
Title: Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.
Physiological stress results in similar expression brain levels of c-Fos in catalepsy-predisposed and control mice.
Title: [Effects of stress on corticosterone level, expression of c-Fos gene and serotonin turnover in brain in mice with genetic predisposition to catalepsy].
Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone.
Title: Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment.
expression of cFOS in the ventral tegmental area (VTA) was reduced after 7 days of restricted feeding in GHSR knock-out animals
Title: Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm.
In wild type mice, the what-when-where-task induced more hipopocampal c-Fos expression than the novelty-Task, which was selective for the CA1 area and correlated with the what-when memory.
Title: Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands.
Epidermal Fos deletion in tumor models induced p53 expression. Epidermal cell differentiation and skin tumor suppression were caused by a p53-dependent transcriptional activation of the metalloprotease TACE.
Title: Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.
c-Src is capable of phosphorylating tyr residues of c-Fos whereas the phosphatase TC45 T-cell protein-tyr phosphatase (TC-PTP) dephosphorylates them
Title: The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity.

Submit: New GeneRIF Correction See all (135)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (knock-in) (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000078.1		Creb1	BIND	PubMed	Creb1 (CREB) interacts with the Fos (c-Fos) promoter.
NP_034364.1	NP_666177.1	Atf7	BIND	PubMed	Fos interacts with C130020M04Rik.
NP_034364.1	NP_038828.1	Barx2	BIND	PubMed	Barx2 interacts with c-fos.
NP_034364.1	NP_075729.2	Eef1d	BIND	PubMed	Fos interacts with Eef1d.
NP_034364.1	NP_034721.1	Jun	BIND	PubMed	Fos interacts with Jun.
NP_034364.1	NP_034722.1	Jund	BIND	PubMed	Fos interacts with Jund1.
NP_034364.1	NP_862896.1	Optn	BIND	PubMed	Fos interacts with Optn.
NP_034364.1	NP_032976.1	Psmc5	BIND	PubMed	Fos interacts with Psmc5.
NP_034364.1	NP_038956.1	Schip1	BIND	PubMed	Fos interacts with Schip1.
NP_034364.1		Tro	BIND	PubMed	Fos interacts with Troarfip1.
NP_034364.1		Tro	BIND	PubMed	Fos interacts with Troarfip2.
NP_034364.1	XP_357389.2	Wdr65	BIND	PubMed	Fos interacts with FLJ32000.
BioGRID:199726	BioGRID:198235	Atf4	BioGRID	PubMed	Two-hybrid
BioGRID:199726	BioGRID:230215	Atf7	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:198303	Barx2	BioGRID	PubMed	Two-hybrid
BioGRID:199726	BioGRID:216612	Cyld	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:211625	Eef1d	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:200297	Hhex	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:200871	Jun	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:199726	BioGRID:200873	Jund	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:201744	Nfe2l2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:214832	Optn	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:202162	Pik3r1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:202430	Psmc5	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:202893	Rit2	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:206029	Schip1	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:220297	Sirt1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:211982	Smarca2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:203337	Smarcb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:237056	Snapc5	BioGRID	PubMed	Reconstituted Complex
BioGRID:199726	BioGRID:207831	Tro	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:199726	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199726	BioGRID:204624	Yy1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of the AP-1 family of transcription factors, organism-specific biosystem (from REACTOME)
Activation of the AP-1 family of transcription factors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Amphetamine addiction, organism-specific biosystem (from KEGG)
Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
Amphetamine addiction, conserved biosystem (from KEGG)
Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
B cell receptor signaling pathway, conserved biosystem (from KEGG)
B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
Circadian entrainment, organism-specific biosystem (from KEGG)
Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Circadian entrainment, conserved biosystem (from KEGG)
Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Colorectal cancer, organism-specific biosystem (from KEGG)
Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Colorectal cancer, conserved biosystem (from KEGG)
Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
MAP kinase activation in TLR cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Oxidative Stress, organism-specific biosystem (from WikiPathways)
Oxidative Stress, organism-specific biosystem
Oxidative Stress
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Salmonella infection, organism-specific biosystem (from KEGG)
Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Salmonella infection, conserved biosystem (from KEGG)
Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Selenium metabolism/Selenoproteins, organism-specific biosystem (from WikiPathways)
Selenium metabolism/Selenoproteins, organism-specific biosystem
Selenium metabolism/Selenoproteins
Serotonin and anxiety, organism-specific biosystem (from WikiPathways)
Serotonin and anxiety, organism-specific biosystemBenekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been imp...
Serotonin and anxiety-related events, organism-specific biosystem (from WikiPathways)
Serotonin and anxiety-related events, organism-specific biosystem
Serotonin and anxiety-related events
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
Signaling of Hepatocyte Growth Factor Receptor
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
T Cell Receptor Signaling Pathway, organism-specific biosystem
T Cell Receptor Signaling Pathway
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
TLR4 (Toll-like receptor 4) signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...

General gene information

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Markers

Fos (e-PCR), detects polymorphism
- UniSTS:143124

Fos (e-PCR), detects polymorphism
- UniSTS:143125

Fos (e-PCR), detects polymorphism
- UniSTS:143126

PMC156147P7 (e-PCR)
- UniSTS:271384

Fos (e-PCR), detects polymorphism
- UniSTS:463409

PMC99986P2 (e-PCR)
- UniSTS:273714

BP240034A10G4 (e-PCR)
- UniSTS:519219

PMC108124P1 (e-PCR)
- UniSTS:270133

PMC151804P3 (e-PCR)
- UniSTS:271177

PMC125577P1 (e-PCR)
- UniSTS:270501

Fos (e-PCR), detects polymorphism
- UniSTS:525222

PMC125577P2 (e-PCR)
- UniSTS:270502

Fos (e-PCR), detects polymorphism
- UniSTS:256935

PMC321436P2 (e-PCR)
- UniSTS:273107

Homology

Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
R-SMAD binding	ISO Inferred from Sequence Orthology more info
double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
cellular response to extracellular stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
response to drug	IDA Inferred from Direct Assay more info	PubMed
skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
membrane	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
nucleus	IC Inferred by Curator more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proto-oncogene c-Fos

Names: proto-oncogene c-Fos; cellular oncogene fos; proto-oncogene protein c-fos

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010234.2 → NP_034364.1 proto-oncogene c-Fos

Status: PROVISIONAL

Source sequence(s)

BC029814

Consensus CDS

CCDS26059.1

UniProtKB/Swiss-Prot

P01101

Related

ENSMUSP00000021674, OTTMUSP00000021331, ENSMUST00000021674, OTTMUST00000047265

Conserved Domains (1) summary

smart00338
Location:147 – 185
Blast Score: 132

BRLZ; basic region leucin zipper

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000078.6 Reference GRCm38.p1 C57BL/6J

Range

85473901..85477269

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000034.1 Alternate Mm_Celera

Range

86933225..86936593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01101991.1 (21777..25145)	None
genomic	AC159244.4 (180780..184148)	None
genomic	CH466590.1	EDL02869.1	mixed
		EDL02870.1	mixed
		EDL02871.1	mixed
genomic	J00370.1	AAA96699.1
genomic	M23768.1	None
genomic	V00727.1	CAA24105.1
mRNA	AK154418.1	BAE32571.1	NOD
mRNA	AK159688.1	None	C57BL/6J
mRNA	AY423854.1	AAR00345.1	SJL/J
mRNA	BC013242.1	None	FVB/N
mRNA	BC029814.1	AAH29814.1	FVB/N