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Fos FBJ osteosarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 14281, updated on 10-May-2016
Official Symbol
Fosprovided by MGI
Official Full Name
FBJ osteosarcoma oncogeneprovided by MGI
Primary source
MGI:MGI:95574
See related
Ensembl:ENSMUSG00000021250 Vega:OTTMUSG00000019764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cFos; c-fos; D12Rfj1
Orthologs
Location:
12 D2; 12 39.7 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (85473901..85477269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (86814851..86818219)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40477 Neighboring gene predicted gene, 38543 Neighboring gene predicted gene, 32296 Neighboring gene predicted gene, 32348

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle stretch IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
proto-oncogene c-Fos
Names
cellular oncogene fos
proto-oncogene protein c-fos

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010234.2NP_034364.1  proto-oncogene c-Fos

    See identical proteins and their annotated locations for NP_034364.1

    Status: PROVISIONAL

    Source sequence(s)
    BC029814
    Consensus CDS
    CCDS26059.1
    UniProtKB/Swiss-Prot
    P01101
    Related
    ENSMUSP00000021674, OTTMUSP00000021331, ENSMUST00000021674, OTTMUST00000047265
    Conserved Domains (1) summary
    cd14721
    Location:147200
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    85473901..85477269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    86933225..86936593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)