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ASB15 ankyrin repeat and SOCS box containing 15 [ Homo sapiens (human) ]

Gene ID: 142685, updated on 8-May-2016
Official Symbol
ASB15provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 15provided by HGNC
Primary source
HGNC:HGNC:19767
See related
Ensembl:ENSG00000146809 HPRD:10669; Vega:OTTHUMG00000157114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Orthologs
Location:
7q31.31
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (123566999..123637900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123241882..123277951)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene lysophospholipase I pseudogene 1 Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene uncharacterized LOC102724555 Neighboring gene leiomodin 2 Neighboring gene Wiskott-Aldrich syndrome like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ43370, DKFZp779M1258

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ankyrin repeat and SOCS box protein 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034019.1 RefSeqGene

    Range
    5001..41031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290258.1NP_001277187.1  ankyrin repeat and SOCS box protein 15

    See identical proteins and their annotated locations for NP_001277187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006333, AF403033, AK125360, BC100874, CR749595
    Consensus CDS
    CCDS34742.1
    UniProtKB/Swiss-Prot
    Q8WXK1
    Related
    ENSP00000416433, OTTHUMP00000211496, ENST00000451215, OTTHUMT00000347495
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. NM_080928.4NP_563616.3  ankyrin repeat and SOCS box protein 15

    See identical proteins and their annotated locations for NP_563616.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006333, AF403033, AK125360, BC100874, CR749595
    Consensus CDS
    CCDS34742.1
    UniProtKB/Swiss-Prot
    Q8WXK1
    Related
    ENSP00000275699, ENST00000275699
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    123566999..123637900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515819.1XP_011514121.1  

    See identical proteins and their annotated locations for XP_011514121.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Related
    ENSP00000397655, OTTHUMP00000211495, ENST00000451558, OTTHUMT00000347493
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. XM_011515818.1XP_011514120.1  

    See identical proteins and their annotated locations for XP_011514120.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. XM_011515817.1XP_011514119.1  

    See identical proteins and their annotated locations for XP_011514119.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  4. XM_005250146.3XP_005250203.1  

    See identical proteins and their annotated locations for XP_005250203.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  5. XM_011515820.1XP_011514122.1  

    See identical proteins and their annotated locations for XP_011514122.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:110142
    Ank; Ankyrin repeat
    pfam12796
    Location:148238
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  6. XM_011515816.1XP_011514118.1  

    Conserved Domains (4) summary
    cd00204
    Location:144269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:116148
    Ank; Ankyrin repeat
    pfam12796
    Location:154244
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:538593
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  7. XM_011515821.1XP_011514123.1  

    Conserved Domains (3) summary
    cd00204
    Location:131249
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:104191
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:485540
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  8. XM_011515822.1XP_011514124.1  

    Conserved Domains (3) summary
    cd00204
    Location:87205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03731
    Location:441496
    SOCS_ASB15; SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of ...
    pfam12796
    Location:59147
    Ank_2; Ankyrin repeats (3 copies)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    123175210..123211250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)