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MIB2 mindbomb E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 142678, updated on 19-Jul-2014
Official Symbol
MIB2provided by HGNC
Official Full Name
mindbomb E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:30577
Locus tag
RP11-345P4.1
See related
Ensembl:ENSG00000197530; HPRD:15905; MIM:611141; Vega:OTTHUMG00000074647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZZZ5; ZZANK1
See MIB2 in Epigenomics, MapViewer
Location:
1p36.33
Exon count :
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (1614969..1630610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1550795..1565990)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) Neighboring gene chromosome 1 open reading frame 233 Neighboring gene matrix metallopeptidase 23B Neighboring gene cyclin-dependent kinase 11B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem (from REACTOME)
    Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystemMature NOTCH1 heterodimer on the cell surface is activated by one of its ligands: DLL1 (Cordle et al. 2008, Jarriault et al. 1998), DLL4 (Benedito et al. 2009), JAG1 (Li et al. 1998, Benedito et al. ...
  • Constitutive Signaling by NOTCH1 HD Domain Mutants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by NOTCH1 HD Domain Mutants, organism-specific biosystemThe heterodimerization (HD) domain of NOTCH1, responsible for association of NOTCH1 extracellular and transmembrane regions after furin-mediated cleavage of NOTCH1 precursor, is one of the hotspots f...
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
    FBXW7 Mutants and NOTCH1 in Cancer, organism-specific biosystemFBXW7 (FBW7) is a component of the SCF (SKP1, CUL1, and F-box protein) ubiquitin ligase complex SCF-FBW7 which is involved in the degradation of NOTCH1 (Oberg et al. 2001, Wu et al. 2001, Fryer et al...
  • NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystem (from REACTOME)
    NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystemSimilar to NOTCH1, NOTCH2 is activated by Delta-like and Jagged ligands (DLL/JAG) expressed in trans on a neighboring cell (Shimizu et al. 1999, Shimizu et al. 2000, Hicks et al. 2000, Ji et al. 2004...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
  • Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 HD Domain Mutants in Cancer, organism-specific biosystemNOTCH1 heterodimerization domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL) (Weng et al. 2004) and result in constitutive activity of NOTCH1 mutants (Malecki et al....
  • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
  • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
  • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
  • Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). The tran...
  • Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH2, organism-specific biosystemNOTCH2 is activated by binding Delta-like and Jagged ligands (DLL/JAG) expressed in trans on neighboring cells (Shimizu et al. 1999, Shimizu et al. 2000, Hicks et al. 2000, Ji et al. 2004). In trans ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
signal transducer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase MIB2
Names
E3 ubiquitin-protein ligase MIB2
novelzin
skeletrophin
mindbomb homolog 2
mind bomb homolog 2
novel zinc finger protein
putative NF-kappa-B-activating protein 002N
zinc finger, ZZ type with ankyrin repeat domain 1
zinc finger ZZ type with ankyrin repeat domain protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170686.1NP_001164157.1  E3 ubiquitin-protein ligase MIB2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AB076693, AL691432, BC037542, DC402226
    Consensus CDS
    CCDS53261.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000428660, OTTHUMP00000220666, ENST00000520777, OTTHUMT00000365934
    Conserved Domains (7) summary
    pfam06701
    Location:127195
    Blast Score: 225
    MIB_HERC2; Mib_herc2
    pfam10921
    Location:364447
    Blast Score: 90
    DUF2710; Protein of unknown function (DUF2710)
    cd00162
    Location:10211058
    Blast Score: 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:574686
    Blast Score: 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    Blast Score: 261
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:580672
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:942983
    Blast Score: 103
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001170687.1NP_001164158.1  E3 ubiquitin-protein ligase MIB2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AB076691, AK302757, AL691432, BC016490, BC037542
    Consensus CDS
    CCDS53263.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000348081, OTTHUMP00000083363, ENST00000355826, OTTHUMT00000158402
    Conserved Domains (6) summary
    pfam06701
    Location:113181
    Blast Score: 225
    MIB_HERC2; Mib_herc2
    cd00162
    Location:10111048
    Blast Score: 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:564676
    Blast Score: 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:190234
    Blast Score: 261
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:570662
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:932973
    Blast Score: 103
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_001170688.1NP_001164159.1  E3 ubiquitin-protein ligase MIB2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AB076692, AL691432, BC037542, DC402226
    Consensus CDS
    CCDS53262.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000428264, OTTHUMP00000083364, ENST00000518681, OTTHUMT00000158404
    Conserved Domains (6) summary
    pfam06701
    Location:127195
    Blast Score: 229
    MIB_HERC2; Mib_herc2
    cd00162
    Location:960997
    Blast Score: 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:513625
    Blast Score: 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    Blast Score: 260
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:519611
    Blast Score: 235
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:881922
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. NM_001170689.1NP_001164160.1  E3 ubiquitin-protein ligase MIB2 isoform 5

    See proteins identical to NP_001164160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, lacks an alternate in-frame exon in the central coding region, and lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, a distinct C-terminus, and is overall shorter than isoform 1.
    Source sequence(s)
    AK128167, AL691432, BC037542, DA391220, DA767833
    Consensus CDS
    CCDS53264.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000367984, OTTHUMP00000083365, ENST00000378712, OTTHUMT00000158407
    Conserved Domains (4) summary
    pfam06701
    Location:1280
    Blast Score: 223
    MIB_HERC2; Mib_herc2
    cd00204
    Location:398510
    Blast Score: 305
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89133
    Blast Score: 268
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:404496
    Blast Score: 230
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_080875.2NP_543151.2  E3 ubiquitin-protein ligase MIB2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB074480, AL691432, BC037542, DC402226
    Consensus CDS
    CCDS41224.2
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000426103, OTTHUMP00000220661, ENST00000505820, OTTHUMT00000365928
    Conserved Domains (6) summary
    pfam06701
    Location:127195
    Blast Score: 225
    MIB_HERC2; Mib_herc2
    cd00162
    Location:10251062
    Blast Score: 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:578690
    Blast Score: 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    Blast Score: 261
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:584676
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:946987
    Blast Score: 103
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RNA

  1. NR_033183.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK122751, AL691432, BC037542, DC402226, FO704657

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    1614969..1630610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710367.1XP_006710430.1  

    Conserved Domains (6) summary
    pfam06701
    Location:410474
    Blast Score: 216
    MIB_HERC2; Mib_herc2
    cd00162
    Location:11811218
    Blast Score: 91
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:734846
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:339383
    Blast Score: 261
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:740832
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:11021137
    Blast Score: 101
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. XM_006710366.1XP_006710429.1  

    Conserved Domains (6) summary
    pfam06701
    Location:410474
    Blast Score: 217
    MIB_HERC2; Mib_herc2
    cd00162
    Location:11931230
    Blast Score: 90
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:713825
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:339383
    Blast Score: 259
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:719811
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:11141149
    Blast Score: 100
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. XM_006710368.1XP_006710431.1  

    Conserved Domains (6) summary
    pfam06701
    Location:410474
    Blast Score: 217
    MIB_HERC2; Mib_herc2
    cd00162
    Location:11601197
    Blast Score: 90
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:713825
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:339383
    Blast Score: 260
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:719811
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:10811116
    Blast Score: 101
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. XM_006710369.1XP_006710432.1  

    Conserved Domains (6) summary
    pfam06701
    Location:410474
    Blast Score: 217
    MIB_HERC2; Mib_herc2
    cd00162
    Location:11571194
    Blast Score: 89
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:677789
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:339383
    Blast Score: 259
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:683775
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:10781113
    Blast Score: 99
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  5. XM_006710370.1XP_006710433.1  

    Conserved Domains (6) summary
    pfam06701
    Location:410474
    Blast Score: 218
    MIB_HERC2; Mib_herc2
    cd00162
    Location:11241161
    Blast Score: 90
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:677789
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:339383
    Blast Score: 260
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:683775
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:10451080
    Blast Score: 100
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  6. XM_006710371.1XP_006710434.1  

    Conserved Domains (6) summary
    pfam06701
    Location:127195
    Blast Score: 225
    MIB_HERC2; Mib_herc2
    cd00162
    Location:10581095
    Blast Score: 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:578690
    Blast Score: 315
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    Blast Score: 260
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:584676
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:9791020
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  7. XM_006710372.1XP_006710435.1  

    Conserved Domains (6) summary
    pfam06701
    Location:127195
    Blast Score: 226
    MIB_HERC2; Mib_herc2
    cd00162
    Location:9891026
    Blast Score: 93
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:542654
    Blast Score: 314
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    Blast Score: 261
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:548640
    Blast Score: 236
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:910951
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  8. XM_006710374.1XP_006710437.1  

    See proteins identical to XP_006710437.1

    Conserved Domains (6) summary
    pfam06701
    Location:1280
    Blast Score: 223
    MIB_HERC2; Mib_herc2
    cd00162
    Location:9641001
    Blast Score: 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:484596
    Blast Score: 311
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89133
    Blast Score: 257
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:490582
    Blast Score: 233
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:885926
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  9. XM_006710373.1XP_006710436.1  

    Conserved Domains (6) summary
    pfam06701
    Location:2694
    Blast Score: 223
    MIB_HERC2; Mib_herc2
    cd00162
    Location:9781015
    Blast Score: 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:498610
    Blast Score: 311
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:103147
    Blast Score: 258
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:504596
    Blast Score: 233
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:899940
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  10. XM_006710375.1XP_006710438.1  

    See proteins identical to XP_006710438.1

    Conserved Domains (6) summary
    pfam06701
    Location:1280
    Blast Score: 223
    MIB_HERC2; Mib_herc2
    cd00162
    Location:9641001
    Blast Score: 92
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    cd00204
    Location:484596
    Blast Score: 311
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89133
    Blast Score: 257
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam12796
    Location:490582
    Blast Score: 233
    Ank_2; Ankyrin repeats (3 copies)
    pfam13920
    Location:885926
    Blast Score: 102
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    824580..841846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    1537413..1553030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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