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Flt4 FMS-like tyrosine kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 14257, updated on 8-May-2016
Official Symbol
Flt4provided by MGI
Official Full Name
FMS-like tyrosine kinase 4provided by MGI
Primary source
MGI:MGI:95561
See related
Ensembl:ENSMUSG00000020357 Vega:OTTMUSG00000005554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chy; Flt-4; VEGFR3; VEGFR-3; AI323512
Orthologs
Location:
11 29.69 cM; 11 A5-B1
Exon count:
30
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (49609679..49652739)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (49423181..49466241)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39480 Neighboring gene predicted gene, 42075 Neighboring gene secretoglobin, family 3A, member 1 Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene ribosomal protein L30 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (1) 
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
    VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
    VEGF ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
vascular endothelial growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
vascular endothelial growth factor receptor 3
Names
chylous ascites
receptor protein tyrosine kinase
tyrosine-protein kinase receptor FLT4
vascular endothelial growth factor receptor-3
NP_032055.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008029.3NP_032055.1  vascular endothelial growth factor receptor 3 precursor

    See identical proteins and their annotated locations for NP_032055.1

    Status: VALIDATED

    Source sequence(s)
    AL646088, BC138346, BU757635, BY311090
    Consensus CDS
    CCDS24618.1
    UniProtKB/Swiss-Prot
    P35917
    UniProtKB/TrEMBL
    Q5SU94
    Related
    ENSMUSP00000020617, OTTMUSP00000005713, ENSMUST00000020617, OTTMUST00000012349
    Conserved Domains (7) summary
    cd00096
    Location:574658
    Ig; Immunoglobulin domain
    cd05862
    Location:245329
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    smart00408
    Location:693755
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:238327
    IG_like; Immunoglobulin like
    pfam07714
    Location:8451169
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:352418
    Ig; Immunoglobulin domain
    cl21453
    Location:8371175
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    49609679..49652739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    54171357..54214402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)