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Fkbp8 FK506 binding protein 8 [ Mus musculus (house mouse) ]

Gene ID: 14232, updated on 28-May-2016
Official Symbol
Fkbp8provided by MGI
Official Full Name
FK506 binding protein 8provided by MGI
Primary source
MGI:MGI:1341070
See related
Ensembl:ENSMUSG00000019428 Vega:OTTMUSG00000031159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
38kDa; FKBP-8; Fkbp38; FKBP-38
Orthologs
Location:
8; 8 C1
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (70527743..70535328)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73051642..73059227)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930522P08 gene Neighboring gene KxDL motif containing 1 Neighboring gene elongation factor RNA polymerase II Neighboring gene predicted gene, 34101 Neighboring gene myo-inositol 1-phosphate synthase A1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
FK506 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
isomerase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
dorsal/ventral neural tube patterning IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral neural tube patterning IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial envelope IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP8
Names
38 kDa FK506-binding protein
38 kDa FKBP
FK506-binding protein 38
FK506-binding protein 8
FKBPR38
PPIase FKBP8
mFKBP38
rotamase
NP_001104536.1
NP_001186560.1
NP_034353.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111066.1NP_001104536.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform a

    See identical proteins and their annotated locations for NP_001104536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AK165281, BB842097, DV644627
    Consensus CDS
    CCDS52575.1
    UniProtKB/Swiss-Prot
    O35465
    Related
    ENSMUSP00000074935, OTTMUSP00000040763, ENSMUST00000075491, OTTMUST00000077188
    Conserved Domains (4) summary
    smart00028
    Location:297330
    TPR; Tetratricopeptide repeats
    pfam00254
    Location:103192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:264328
    TPR_11; TPR repeat
    sd00006
    Location:245292
    TPR; TPR repeat [structural motif]
  2. NM_001199631.1NP_001186560.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform a

    See identical proteins and their annotated locations for NP_001186560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC157774, AK165281, DV644627
    Consensus CDS
    CCDS52575.1
    UniProtKB/Swiss-Prot
    O35465
    Related
    ENSMUSP00000114069, OTTMUSP00000040764, ENSMUST00000119698, OTTMUST00000077189
    Conserved Domains (4) summary
    smart00028
    Location:297330
    TPR; Tetratricopeptide repeats
    pfam00254
    Location:103192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:264328
    TPR_11; TPR repeat
    sd00006
    Location:245292
    TPR; TPR repeat [structural motif]
  3. NM_010223.2NP_034353.2  peptidyl-prolyl cis-trans isomerase FKBP8 isoform b

    See identical proteins and their annotated locations for NP_034353.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1. The resulting protein (isoform b) is one amino acid shorter than isoform a.
    Source sequence(s)
    AK165281, BB842097, DV644627
    Consensus CDS
    CCDS52576.1
    UniProtKB/Swiss-Prot
    O35465
    Related
    ENSMUSP00000112527, OTTMUSP00000040762, ENSMUST00000119353, OTTMUST00000077187
    Conserved Domains (4) summary
    smart00028
    Location:296329
    TPR; Tetratricopeptide repeats
    pfam00254
    Location:103191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:263327
    TPR_11; TPR repeat
    sd00006
    Location:244291
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    70527743..70535328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509556.2XP_006509619.1  

    See identical proteins and their annotated locations for XP_006509619.1

    UniProtKB/Swiss-Prot
    O35465
    Conserved Domains (4) summary
    smart00028
    Location:297330
    TPR; Tetratricopeptide repeats
    pfam00254
    Location:103192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13414
    Location:264328
    TPR_11; TPR repeat
    sd00006
    Location:245292
    TPR; TPR repeat [structural motif]

RNA

  1. XR_379034.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    73084164..73091753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)