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Ctgf connective tissue growth factor [ Mus musculus (house mouse) ]

Gene ID: 14219, updated on 8-May-2016
Official Symbol
Ctgfprovided by MGI
Official Full Name
connective tissue growth factorprovided by MGI
Primary source
MGI:MGI:95537
See related
Ensembl:ENSMUSG00000019997 Vega:OTTMUSG00000019709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccn2; Hcs24; Fisp12; fisp-12
Orthologs
Location:
10 11.84 cM; 10 A3-B1
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (24595442..24598683)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (24315248..24318489)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102638890 Neighboring gene predicted gene, 40615 Neighboring gene predicted gene, 36089 Neighboring gene predicted gene 6893 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage condensation IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
connective tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosolic calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
connective tissue growth factor
Names
CCN family member 2
Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
fibroblast inducible secreated protein
fibroblast inducible secreted protein
hypertrophic chondrocyte-specific gene product 24
hypertrophic chondrocyte-specific protein 24

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010217.2NP_034347.2  connective tissue growth factor precursor

    See identical proteins and their annotated locations for NP_034347.2

    Status: VALIDATED

    Source sequence(s)
    BQ031485, BQ892143, BQ917383, CB317714, CJ055589, CJ159336
    Consensus CDS
    CCDS23751.1
    UniProtKB/Swiss-Prot
    P29268
    Related
    ENSMUSP00000020171, OTTMUSP00000021306, ENSMUST00000020171, OTTMUST00000047191
    Conserved Domains (4) summary
    smart00214
    Location:102161
    VWC; von Willebrand factor (vWF) type C domain
    pfam00090
    Location:201241
    TSP_1; Thrombospondin type 1 domain
    pfam00219
    Location:4081
    IGFBP; Insulin-like growth factor binding protein
    cl21545
    Location:252344
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    24595442..24598683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    25537033..25540272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)