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Fgr FGR proto-oncogene, Src family tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 14191, updated on 28-May-2016
Official Symbol
Fgrprovided by MGI
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:95527
See related
Ensembl:ENSMUSG00000028874 Vega:OTTMUSG00000010096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
4 D2.3; 4 66.11 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (132974095..133001893)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (132530010..132557808)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A Neighboring gene predicted gene, 36518 Neighboring gene predicted gene, 36599 Neighboring gene AT hook, DNA binding motif, containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
p55-Fgr
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase Fgr
NP_034338.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010208.4NP_034338.3  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_034338.3

    Status: VALIDATED

    Source sequence(s)
    AI661913, AK038141, AK155902, BY204076
    Consensus CDS
    CCDS18739.1
    UniProtKB/Swiss-Prot
    P14234
    Related
    ENSMUSP00000030693, OTTMUSP00000010727, ENSMUST00000030693, OTTMUST00000023486
    Conserved Domains (4) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    pfam07714
    Location:251500
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    132974095..133001893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538544.2XP_006538607.1  

    See identical proteins and their annotated locations for XP_006538607.1

    UniProtKB/Swiss-Prot
    P14234
    Conserved Domains (4) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    pfam07714
    Location:251500
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006538545.2XP_006538608.1  

    See identical proteins and their annotated locations for XP_006538608.1

    UniProtKB/Swiss-Prot
    P14234
    Related
    ENSMUSP00000128411, ENSMUST00000171223
    Conserved Domains (4) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    pfam07714
    Location:251500
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    131136566..131164622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)