Format

Send to:

Choose Destination

Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 14184, updated on 28-May-2016
Official Symbol
Fgfr3provided by MGI
Official Full Name
fibroblast growth factor receptor 3provided by MGI
Primary source
MGI:MGI:95524
See related
Ensembl:ENSMUSG00000054252 Vega:OTTMUSG00000021524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3
Summary
This gene encodes a member of the fibroblast growth factor receptor family. Members of this family are highly conserved proteins that differ from one another in their ligand affinities and tissue distribution. A representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene may be associated with craniosynostosis and multiple types of skeletal dysplasia. A pseudogene of this gene is located on chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Orthologs
Location:
5 17.83 cM; 5 B
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (33721724..33737068)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34064373..34079713)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 129 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene, 30708

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
alveolar secondary septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axonogenesis involved in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
inner ear receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lens fiber cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation in bone marrow IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat1 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of collagen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
substantia nigra development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
transport vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibroblast growth factor receptor 3
Names
heparin-binding growth factor receptor
NP_001156687.1
NP_001156688.1
NP_001156689.1
NP_001192199.1
NP_032036.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163215.2NP_001156687.1  fibroblast growth factor receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156687.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1, also known as IIIc), which includes the IIIc-type C-terminal half of the IgIII domain.
    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS51465.1
    UniProtKB/TrEMBL
    Q7TSI8
    Related
    ENSMUSP00000130856, ENSMUST00000169212
    Conserved Domains (7) summary
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:453786
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:466742
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001163216.2NP_001156688.1  fibroblast growth factor receptor 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156688.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC162898, AF024638
    Consensus CDS
    CCDS51466.1
    UniProtKB/TrEMBL
    Q61563
    Related
    ENSMUSP00000143945, ENSMUST00000202138
    Conserved Domains (7) summary
    cd05857
    Location:137221
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:244333
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:435768
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:146211
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:236332
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:448724
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001163217.2NP_001156689.1  fibroblast growth factor receptor 3 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001156689.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a coding exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3, also known as IIIb) is longer than isoform 1 and includes the IIIb-type C-terminal half of the IgIII domain. The combination of alternative exons and splice sites in the coding region is inferred based on human NM_001163213.1.
    Source sequence(s)
    AC162898
    UniProtKB/TrEMBL
    E9QNJ9
    Related
    ENSMUSP00000131845, ENSMUST00000171509
    Conserved Domains (7) summary
    cd04974
    Location:262350
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:455788
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254349
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:468744
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001205270.1NP_001192199.1  fibroblast growth factor receptor 3 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC162898
    Consensus CDS
    CCDS57335.1
    UniProtKB/TrEMBL
    F6TK14
    Related
    ENSMUSP00000133064, OTTMUSP00000062900, ENSMUST00000164207, OTTMUST00000112075
    Conserved Domains (7) summary
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:454787
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:467743
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_008010.5NP_032036.2  fibroblast growth factor receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032036.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also known as IIIc, which includes the IIIc-type C-terminal half of the IgIII domain. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162898, BC053056, CD349897
    Consensus CDS
    CCDS51465.1
    UniProtKB/TrEMBL
    Q7TSI8
    Related
    ENSMUSP00000070998, OTTMUSP00000023967, ENSMUST00000067150, OTTMUST00000051048
    Conserved Domains (7) summary
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:453786
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:466742
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    33721724..33737068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503725.1XP_006503788.1  

    See identical proteins and their annotated locations for XP_006503788.1

    Conserved Domains (7) summary
    cd04974
    Location:267355
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155244
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:462795
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164234
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259354
    IG_like; Immunoglobulin like
    pfam07714
    Location:475751
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:62108
    Ig; Immunoglobulin domain
  2. XM_006503727.1XP_006503790.1  

    Conserved Domains (7) summary
    cd04974
    Location:262350
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:457790
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254349
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:470746
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_006503728.1XP_006503791.1  

    See identical proteins and their annotated locations for XP_006503791.1

    UniProtKB/TrEMBL
    E9QNJ9
    Related
    ENSMUSP00000110053, ENSMUST00000114411
    Conserved Domains (7) summary
    cd04974
    Location:262350
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:455788
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164229
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:254349
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:468744
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_006503726.1XP_006503789.1  

    See identical proteins and their annotated locations for XP_006503789.1

    Conserved Domains (7) summary
    cd04974
    Location:267355
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155244
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:462795
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:164234
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:259354
    IG_like; Immunoglobulin like
    pfam07714
    Location:475751
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:62108
    Ig; Immunoglobulin domain
  5. XM_006503730.1XP_006503793.1  

    See identical proteins and their annotated locations for XP_006503793.1

    Conserved Domains (7) summary
    cd04974
    Location:249337
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:137226
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:444777
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:146216
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:241336
    IG_like; Immunoglobulin like
    pfam07714
    Location:457733
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:62108
    Ig; Immunoglobulin domain
  6. XM_006503729.1XP_006503792.1  

    See identical proteins and their annotated locations for XP_006503792.1

    Conserved Domains (7) summary
    cd04974
    Location:249337
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:137226
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:444777
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:146216
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:241336
    IG_like; Immunoglobulin like
    pfam07714
    Location:457733
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:62108
    Ig; Immunoglobulin domain
  7. XM_006503731.2XP_006503794.1  

    See identical proteins and their annotated locations for XP_006503794.1

    UniProtKB/TrEMBL
    Q61563
    Related
    ENSMUSP00000085122, OTTMUSP00000023968, ENSMUST00000087820, OTTMUST00000051049
    Conserved Domains (7) summary
    cd05857
    Location:137221
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:244333
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:435768
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:146211
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:236332
    IG_like; Immunoglobulin like
    pfam00047
    Location:52109
    ig; Immunoglobulin domain
    pfam07714
    Location:448724
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_006503713.2XP_006503776.1  

    Conserved Domains (7) summary
    cd04974
    Location:295383
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:490823
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287382
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:503779
    Pkinase_Tyr; Protein tyrosine kinase
  9. XM_006503714.2XP_006503777.1  

    Conserved Domains (7) summary
    cd04974
    Location:295383
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:489822
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287382
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:502778
    Pkinase_Tyr; Protein tyrosine kinase
  10. XM_006503723.2XP_006503786.1  

    Conserved Domains (7) summary
    cd04974
    Location:277365
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:165254
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:472805
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:174244
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:269364
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:485761
    Pkinase_Tyr; Protein tyrosine kinase
  11. XM_006503716.2XP_006503779.1  

    Conserved Domains (7) summary
    cd04974
    Location:295383
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:488821
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287382
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:501777
    Pkinase_Tyr; Protein tyrosine kinase
  12. XM_006503719.2XP_006503782.1  

    Conserved Domains (7) summary
    cd04974
    Location:290378
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:485818
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282377
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:498774
    Pkinase_Tyr; Protein tyrosine kinase
  13. XM_006503715.2XP_006503778.1  

    Conserved Domains (7) summary
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:295384
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:488821
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287383
    IG_like; Immunoglobulin like
    pfam07714
    Location:501777
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:90136
    Ig; Immunoglobulin domain
  14. XM_006503717.2XP_006503780.1  

    Conserved Domains (7) summary
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:295384
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:487820
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287383
    IG_like; Immunoglobulin like
    pfam07714
    Location:500776
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:90136
    Ig; Immunoglobulin domain
  15. XM_006503718.2XP_006503781.1  

    Conserved Domains (7) summary
    cd05857
    Location:183272
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:295384
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:486819
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192262
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:287383
    IG_like; Immunoglobulin like
    pfam07714
    Location:499775
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:90136
    Ig; Immunoglobulin domain
  16. XM_006503721.2XP_006503784.1  

    Conserved Domains (7) summary
    cd04974
    Location:290378
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:483816
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282377
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:496772
    Pkinase_Tyr; Protein tyrosine kinase
  17. XM_006503720.2XP_006503783.1  

    Conserved Domains (7) summary
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:483816
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:496772
    Pkinase_Tyr; Protein tyrosine kinase
  18. XM_006503724.2XP_006503787.1  

    Conserved Domains (7) summary
    cd05857
    Location:165249
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:272361
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:465798
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:174239
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:264360
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
  19. XM_006503722.2XP_006503785.1  

    Conserved Domains (7) summary
    cd05857
    Location:183267
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:290379
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:481814
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:192257
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:282378
    IG_like; Immunoglobulin like
    pfam00047
    Location:80137
    ig; Immunoglobulin domain
    pfam07714
    Location:494770
    Pkinase_Tyr; Protein tyrosine kinase
  20. XM_006503732.2XP_006503795.1  

    Conserved Domains (6) summary
    cd04974
    Location:110198
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:387
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:305638
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:1277
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:102197
    IG_like; Immunoglobulin like
    pfam07714
    Location:318594
    Pkinase_Tyr; Protein tyrosine kinase

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    31197840..31213184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)