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Fgf8 fibroblast growth factor 8 [ Mus musculus (house mouse) ]

Gene ID: 14179, updated on 28-May-2016
Official Symbol
Fgf8provided by MGI
Official Full Name
fibroblast growth factor 8provided by MGI
Primary source
MGI:MGI:99604
See related
Ensembl:ENSMUSG00000025219 Vega:OTTMUSG00000021697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aigf; Fgf-8
Orthologs
Location:
19 38.75 cM; 19 C3-D
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (45736798..45742935, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45811288..45817374, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene F-box and WD-40 domain protein 4 Neighboring gene RIKEN cDNA 4933429K18 gene Neighboring gene meningioma expressed antigen 5 (hyaluronidase) Neighboring gene nucleoplasmin 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC59627

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 1 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 2 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
aorta morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
bone development ISO
Inferred from Sequence Orthology
more info
 
branching involved in salivary gland morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
cell migration involved in mesendoderm migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
corticotropin hormone secreting cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
dorsal/ventral axon guidance ISO
Inferred from Sequence Orthology
more info
 
embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
forebrain dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain neuron development ISO
Inferred from Sequence Orthology
more info
 
generation of neurons IMP
Inferred from Mutant Phenotype
more info
PubMed 
gonad development ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
male genitalia development IDA
Inferred from Direct Assay
more info
PubMed 
mesodermal cell migration IC
Inferred by Curator
more info
PubMed 
mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural plate morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
organ induction IGI
Inferred from Genetic Interaction
more info
PubMed 
otic vesicle formation IGI
Inferred from Genetic Interaction
more info
PubMed 
outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
pallium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
patterning of blood vessels IGI
Inferred from Genetic Interaction
more info
PubMed 
pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of organ growth IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
subpallium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid-stimulating hormone-secreting cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibroblast growth factor 8
Names
HBGF-8
androgen-induced growth factor
heparin-binding growth factor 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166361.1NP_001159833.1  fibroblast growth factor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159833.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate internal 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (2) is shorter and has a different segment in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    BC048734, BU512456
    Consensus CDS
    CCDS50452.1
    UniProtKB/TrEMBL
    Q80ZL6
    Related
    ENSMUSP00000026240, OTTMUSP00000024237, ENSMUST00000026240, OTTMUST00000051478
    Conserved Domains (1) summary
    cd00058
    Location:83207
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. NM_001166362.1NP_001159834.1  fibroblast growth factor 8 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001159834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate internal 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (3) is shorter and has a different segment in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    BC048734, BU512456, D12482
    Consensus CDS
    CCDS50451.1
    UniProtKB/Swiss-Prot
    P37237
    UniProtKB/TrEMBL
    Q3V279, Q80ZL6
    Related
    ENSMUSP00000107559, OTTMUSP00000024238, ENSMUST00000111928, OTTMUST00000051479
    Conserved Domains (1) summary
    cd00058
    Location:54178
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  3. NM_001166363.1NP_001159835.1  fibroblast growth factor 8 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001159835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' coding region, as compared to variant 1. The reading frame is not changed and the resulting isoform (4) lacks an internal segment in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    BC048734, BU512456, U18673
    Consensus CDS
    CCDS50450.1
    UniProtKB/Swiss-Prot
    P37237
    UniProtKB/TrEMBL
    Q80ZL6
    Related
    ENSMUSP00000107558, OTTMUSP00000024239, ENSMUST00000111927, OTTMUST00000051480
    Conserved Domains (1) summary
    cd00058
    Location:43167
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  4. NM_010205.2NP_034335.1  fibroblast growth factor 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034335.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC048734, BU512456, D12483
    Consensus CDS
    CCDS29864.1
    UniProtKB/Swiss-Prot
    P37237
    UniProtKB/TrEMBL
    Q80ZL6
    Related
    ENSMUSP00000026241, OTTMUSP00000024240, ENSMUST00000026241, OTTMUST00000051481
    Conserved Domains (1) summary
    cd00058
    Location:107231
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    45736798..45742935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526668.2XP_006526731.1  

    See identical proteins and their annotated locations for XP_006526731.1

    UniProtKB/TrEMBL
    D3Z207
    Related
    ENSMUSP00000107556, OTTMUSP00000024242, ENSMUST00000111925, OTTMUST00000051483
    Conserved Domains (1) summary
    cd00058
    Location:72196
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. XM_011247143.1XP_011245445.1  

    See identical proteins and their annotated locations for XP_011245445.1

    UniProtKB/TrEMBL
    D3Z208
    Related
    ENSMUSP00000107555, OTTMUSP00000024241, ENSMUST00000111924, OTTMUST00000051482
    Conserved Domains (1) summary
    cd00058
    Location:1103
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  3. XM_011247142.1XP_011245444.1  

    See identical proteins and their annotated locations for XP_011245444.1

    UniProtKB/TrEMBL
    D3Z208
    Conserved Domains (1) summary
    cd00058
    Location:1103
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    46499127..46505223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)