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Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]

Gene ID: 14164, updated on 3-Apr-2016
Official Symbol
Fgf1provided by MGI
Official Full Name
fibroblast growth factor 1provided by MGI
Primary source
MGI:MGI:95515
See related
Ensembl:ENSMUSG00000036585 Vega:OTTMUSG00000020317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam; Fgfa; Dffrx; Fgf-1
Orthologs
Location:
18 B3; 18 20.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (38838672..38929470, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (38998327..39078353, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 38447 Neighboring gene predicted gene 5820 Neighboring gene predicted gene, 41706 Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene, 41705

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Melanoma, organism-specific biosystem (from KEGG)
    Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • Melanoma, conserved biosystem (from KEGG)
    Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystem
    Regulation of Actin Cytoskeleton
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
branch elongation involved in ureteric bud branching ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lung development IDA
Inferred from Direct Assay
more info
PubMed 
mesonephric epithelium development ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
organ induction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
fibroblast growth factor 1
Names
HBGF-1
aFGF
acidic fibroblast growth factor
fibroblast growth factor 1 (acidic)
heparin-binding growth factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010197.3NP_034327.1  fibroblast growth factor 1 precursor

    See identical proteins and their annotated locations for NP_034327.1

    Status: VALIDATED

    Source sequence(s)
    AC132098, AK035330
    Consensus CDS
    CCDS29204.1
    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Related
    ENSMUSP00000045710, OTTMUSP00000022029, ENSMUST00000040647, OTTMUST00000048206
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    38838672..38929470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525647.2XP_006525710.1  

    See identical proteins and their annotated locations for XP_006525710.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. XM_006525644.2XP_006525707.1  

    See identical proteins and their annotated locations for XP_006525707.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  3. XM_011246843.1XP_011245145.1  

    See identical proteins and their annotated locations for XP_011245145.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  4. XM_011246842.1XP_011245144.1  

    See identical proteins and their annotated locations for XP_011245144.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  5. XM_006525648.2XP_006525711.1  

    See identical proteins and their annotated locations for XP_006525711.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  6. XM_011246841.1XP_011245143.1  

    Conserved Domains (1) summary
    cd00058
    Location:46168
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  7. XM_006525649.1XP_006525712.1  

    See identical proteins and their annotated locations for XP_006525712.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  8. XM_006525642.2XP_006525705.1  

    Conserved Domains (1) summary
    cd00058
    Location:51172
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  9. XM_006525641.2XP_006525704.1  

    Conserved Domains (1) summary
    cd00058
    Location:51173
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  10. XM_006525645.2XP_006525708.1  

    See identical proteins and their annotated locations for XP_006525708.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Related
    ENSMUSP00000111245, OTTMUSP00000022030, ENSMUST00000115582, OTTMUST00000048207
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    40186840..40265902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)