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    Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14164, updated on 11-May-2013
    Official Symbol
    Fgf1provided by MGI
    Official Full Name
    fibroblast growth factor 1provided by MGI
    Primary source
    MGI:95515
    See related
    Ensembl:ENSMUSG00000036585; Vega:OTTMUSG00000020317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam; Fgfa; Dffrx; Fgf-1
    Location :
    18 B3; 18 20.74 cM
    Sequence :
    Chromosome: 18; NC_000084.6 (38838673..38918699, complement)
    See Fgf1 in Epigenomics, MapViewer

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15335 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene 5820 Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene 15337 Neighboring gene nuclear receptor subfamily 3, group C, member 1

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:199638 BioGRID:112101 RPS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branch elongation involved in ureteric bud branching ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell proliferation TAS
    Traceable Author Statement
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesonephric epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    organ induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intracellular protein kinase cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
     
    vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    fibroblast growth factor 1
    Names
    fibroblast growth factor 1
    aFGF
    HBGF-1
    acidic fibroblast growth factor
    heparin-binding growth factor 1
    fibroblast growth factor 1 (acidic)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010197.3NP_034327.1  fibroblast growth factor 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC132098, AK035330
      Consensus CDS
      CCDS29204.1
      UniProtKB/Swiss-Prot
      P61148
      UniProtKB/TrEMBL
      Q6ZWS1
      Related
      ENSMUSP00000045710, OTTMUSP00000022029, ENSMUST00000040647, OTTMUST00000048206
      Conserved Domains (1) summary
      cd00058
      Location:29151
      Blast Score: 385
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p1 C57BL/6J

      Range
      38838673..38918699, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      40186840..40265902, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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