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Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]

Gene ID: 14164, updated on 12-Apr-2014
Official Symbol
Fgf1provided by MGI
Official Full Name
fibroblast growth factor 1provided by MGI
Primary source
MGI:95515
See related
Ensembl:ENSMUSG00000036585; Vega:OTTMUSG00000020317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam; Fgfa; Dffrx; Fgf-1
Location :
18 B3; 18 20.74 cM
Sequence :
Chromosome: 18; NC_000084.6 (38838672..38929471, complement)
See Fgf1 in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102632661 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene 5820 Neighboring gene uncharacterized LOC102632583 Neighboring gene uncharacterized LOC102632517

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
branch elongation involved in ureteric bud branching ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation TAS
Traceable Author Statement
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lung development IDA
Inferred from Direct Assay
more info
PubMed 
mesonephric epithelium development ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
organ induction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
fibroblast growth factor 1
Names
fibroblast growth factor 1
aFGF
HBGF-1
acidic fibroblast growth factor
heparin-binding growth factor 1
fibroblast growth factor 1 (acidic)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010197.3NP_034327.1  fibroblast growth factor 1 precursor

    See proteins identical to NP_034327.1

    Status: VALIDATED

    Source sequence(s)
    AC132098, AK035330
    Consensus CDS
    CCDS29204.1
    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Related
    ENSMUSP00000045710, OTTMUSP00000022029, ENSMUST00000040647, OTTMUST00000048206
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000084.6

    Range
    38838672..38929471, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525647.1XP_006525710.1  

    See proteins identical to XP_006525710.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. XM_006525644.1XP_006525707.1  

    See proteins identical to XP_006525707.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  3. XM_006525646.1XP_006525709.1  

    See proteins identical to XP_006525709.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  4. XM_006525648.1XP_006525711.1  

    See proteins identical to XP_006525711.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  5. XM_006525649.1XP_006525712.1  

    See proteins identical to XP_006525712.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  6. XM_006525642.1XP_006525705.1  

    Conserved Domains (1) summary
    cd00058
    Location:51172
    Blast Score: 412
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  7. XM_006525641.1XP_006525704.1  

    Conserved Domains (1) summary
    cd00058
    Location:51173
    Blast Score: 424
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  8. XM_006525645.1XP_006525708.1  

    See proteins identical to XP_006525708.1

    UniProtKB/Swiss-Prot
    P61148
    UniProtKB/TrEMBL
    Q6ZWS1
    Conserved Domains (1) summary
    cd00058
    Location:29151
    Blast Score: 421
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  9. XM_006525643.1XP_006525706.1  

    Conserved Domains (1) summary
    cd00058
    Location:49171
    Blast Score: 422
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    40186840..40265902, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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