Format

Send to:

Choose Destination

Fbln2 fibulin 2 [ Mus musculus (house mouse) ]

Gene ID: 14115, updated on 28-May-2016
Official Symbol
Fbln2provided by MGI
Official Full Name
fibulin 2provided by MGI
Primary source
MGI:MGI:95488
See related
Ensembl:ENSMUSG00000064080 Vega:OTTMUSG00000022459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIBL-2; 5730577E14Rik
Orthologs
Location:
6 D; 6 40.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (91212764..91272540)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (91162758..91222534)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30364 Neighboring gene histone deacetylase 11 Neighboring gene wingless-type MMTV integration site family, member 7A Neighboring gene predicted gene, 30437

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081437.1NP_001074906.1  fibulin-2 isoform b precursor

    See identical proteins and their annotated locations for NP_001074906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
    Source sequence(s)
    AC131764, AK168688, BY690088
    Consensus CDS
    CCDS39567.1
    UniProtKB/TrEMBL
    Q3TGL4
    Related
    ENSMUSP00000109126, OTTMUSP00000025547, ENSMUST00000113498, OTTMUST00000053703
    Conserved Domains (5) summary
    cd00017
    Location:420479
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd00054
    Location:848890
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:754798
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:952975
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:895931
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_007992.2NP_032018.2  fibulin-2 isoform a precursor

    See identical proteins and their annotated locations for NP_032018.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC121990, AC131764
    Consensus CDS
    CCDS39566.1
    UniProtKB/Swiss-Prot
    P37889
    Related
    ENSMUSP00000048334, OTTMUSP00000025548, ENSMUST00000041544, OTTMUST00000053704
    Conserved Domains (6) summary
    cd00017
    Location:420479
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd00054
    Location:895937
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:801845
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:9991022
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:942978
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:707749
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    91212764..91272540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505530.2XP_006505593.1  

    See identical proteins and their annotated locations for XP_006505593.1

    UniProtKB/Swiss-Prot
    P37889
    Conserved Domains (6) summary
    cd00017
    Location:420479
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd00054
    Location:895937
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:801845
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:9991022
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:942978
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:707749
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    93105530..93166173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)