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Srsf10 serine/arginine-rich splicing factor 10 [ Mus musculus (house mouse) ]

Gene ID: 14105, updated on 8-May-2016
Official Symbol
Srsf10provided by MGI
Official Full Name
serine/arginine-rich splicing factor 10provided by MGI
Primary source
MGI:MGI:1333805
See related
Ensembl:ENSMUSG00000028676 Vega:OTTMUSG00000009794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nssr; TASR; NSSR1; NSSR2; TASR1; TASR2; FUSIP2; Fusip1; SRrp40; Sfrs13a; Srsf13a
Orthologs
Location:
4; 4 D3
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (135855728..135869908)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (135412007..135425823)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene myomesin family, member 3 Neighboring gene predicted gene, 31020 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene cannabinoid receptor 2 (macrophage)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
RNA splicing, via transesterification reactions IDA
Inferred from Direct Assay
more info
PubMed 
RNA splicing, via transesterification reactions ISO
Inferred from Sequence Orthology
more info
 
cytosolic transport IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA splice site selection IC
Inferred by Curator
more info
PubMed 
mRNA splice site selection ISO
Inferred from Sequence Orthology
more info
 
mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/arginine-rich splicing factor 10
Names
FUS-interacting serine-arginine-rich protein 1
Fus-associated protein with serine-arginine repeats
TLS-associated SR protein
TLS-associated protein with SR repeats
TLS-associated protein with Ser-Arg repeats
TLS-associated serine-arginine protein
neural-salient serine/arginine-rich protein
neural-specific SR protein
serine/arginine-rich splicing factor 13A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080387.2NP_001073856.1  serine/arginine-rich splicing factor 10 isoform 2

    See identical proteins and their annotated locations for NP_001073856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AK168558, BC043060, BY244789, BY717856
    Consensus CDS
    CCDS38922.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    Related
    ENSMUSP00000101479, OTTMUSP00000010356, ENSMUST00000105853, OTTMUST00000022692
    Conserved Domains (2) summary
    smart00360
    Location:1183
    RRM; RNA recognition motif
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001284195.1NP_001271124.1  serine/arginine-rich splicing factor 10 isoform 3

    See identical proteins and their annotated locations for NP_001271124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AK168524, BC043060, BY244789, BY717856, CF914989, CN528501
    Consensus CDS
    CCDS71493.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    Related
    ENSMUSP00000095455, OTTMUSP00000010358, ENSMUST00000097844, OTTMUST00000022694
    Conserved Domains (2) summary
    smart00360
    Location:1183
    RRM; RNA recognition motif
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001284196.1NP_001271125.1  serine/arginine-rich splicing factor 10 isoform 4

    See identical proteins and their annotated locations for NP_001271125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and contains an alternate 3' terminal exon, compared to variant 2. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AF042383, AK030968, AK168571, AK169071, BY244789, BY717856
    Consensus CDS
    CCDS71494.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    UniProtKB/TrEMBL
    Q3TFP0, Q3UA07
    Related
    ENSMUSP00000099603, OTTMUSP00000010359, ENSMUST00000102544, OTTMUST00000022695
    Conserved Domains (2) summary
    smart00360
    Location:1183
    RRM; RNA recognition motif
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_010178.3NP_034308.1  serine/arginine-rich splicing factor 10 isoform 1

    See identical proteins and their annotated locations for NP_034308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 3' terminal exon compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AF042383, AK030968, AK168558, AK168571, BY244789, BY717856
    Consensus CDS
    CCDS18791.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    UniProtKB/TrEMBL
    Q3UA07
    Related
    ENSMUSP00000114564, OTTMUSP00000010357, ENSMUST00000126641, OTTMUST00000022693
    Conserved Domains (2) summary
    smart00360
    Location:1183
    RRM; RNA recognition motif
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    135855728..135869908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250188.1XP_011248490.1  

    See identical proteins and their annotated locations for XP_011248490.1

    Conserved Domains (2) summary
    smart00360
    Location:1183
    RRM; RNA recognition motif
    cl17169
    Location:1093
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    134050487..134064492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)