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Fasn fatty acid synthase [ Mus musculus (house mouse) ]

Gene ID: 14104, updated on 30-May-2016
Official Symbol
Fasnprovided by MGI
Official Full Name
fatty acid synthaseprovided by MGI
Primary source
MGI:MGI:95485
See related
Ensembl:ENSMUSG00000025153 Vega:OTTMUSG00000004143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FAS; A630082H08Rik
Orthologs
Location:
11 E2; 11 84.56 cM
Exon count:
43
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (120805958..120824547, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (120667272..120685861, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1-like (S. cerevisiae) Neighboring gene coiled-coil domain containing 57 Neighboring gene uncharacterized LOC105243655

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxo-pimeloyl-[acp] methyl ester reductase activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH binding ISO
Inferred from Sequence Orthology
more info
 
[acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
[acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
acyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
Inferred from Electronic Annotation
more info
 
enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid synthase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
myristoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oleoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
glycogen granule IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007988.3NP_032014.3  fatty acid synthase

    See identical proteins and their annotated locations for NP_032014.3

    Status: VALIDATED

    Source sequence(s)
    AF127033, AK078721, AK080374, AK147694, CJ125823
    Consensus CDS
    CCDS25759.1
    UniProtKB/Swiss-Prot
    P19096
    Related
    ENSMUSP00000052872, OTTMUSP00000004562, ENSMUST00000055655, OTTMUST00000009377
    Conserved Domains (12) summary
    pfam00698
    Location:493810
    Acyl_transf_1; Acyl transferase domain
    cd05195
    Location:15591847
    enoyl_red; enoyl reductase of polyketide synthase
    cd08954
    Location:18692105
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:21182173
    PKS_PP; Phosphopantetheine attachment site
    smart00829
    Location:15571847
    PKS_ER; Enoylreductase
    COG3321
    Location:11015
    PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
    cd00833
    Location:2404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00106
    Location:18782046
    adh_short; short chain dehydrogenase
    pfam00975
    Location:22352494
    Thioesterase; Thioesterase domain
    pfam08242
    Location:12391337
    Methyltransf_12; Methyltransferase domain
    pfam13847
    Location:12341377
    Methyltransf_31; Methyltransferase domain
    pfam14765
    Location:8671012
    PS-DH; Polyketide synthase dehydratase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    120805958..120824547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    132542449..132561038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)