Format

Send to:

Choose Destination

Cdk5 cyclin-dependent kinase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140908, updated on 29-May-2016
Official Symbol
Cdk5provided by RGD
Official Full Name
cyclin-dependent kinase 5provided by RGD
Primary source
RGD:70514
See related
Ensembl:ENSRNOG00000008017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression [RGD, Feb 2006]
Orthologs
Location:
4q11
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7282945..7287427)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (7294309..7298791)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene Fas-activated serine/threonine kinase Neighboring gene solute carrier family 4 member 2 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene ATP binding cassette subfamily B member 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ErbB-2 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
ErbB-2 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
ErbB-3 class receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
acetylcholine receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Schwann cell development IEA
Inferred from Electronic Annotation
more info
 
Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
axon extension TAS
Traceable Author Statement
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
cerebellar cortex development ISO
Inferred from Sequence Orthology
more info
 
cerebellar cortex formation IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex formation ISO
Inferred from Sequence Orthology
more info
 
cerebellum development ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
corpus callosum development ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex ISO
Inferred from Sequence Orthology
more info
 
motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to synapse IEA
Inferred from Electronic Annotation
more info
 
protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
receptor clustering IEA
Inferred from Electronic Annotation
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine ISO
Inferred from Sequence Orthology
more info
 
response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
serine phosphorylation of STAT3 protein IEA
Inferred from Electronic Annotation
more info
 
serine phosphorylation of STAT3 protein ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
synapse assembly IEA
Inferred from Electronic Annotation
more info
 
synapse assembly ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
telencephalon development ISO
Inferred from Sequence Orthology
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell junction TAS
Traceable Author Statement
more info
PubMed 
cyclin-dependent protein kinase 5 holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
filopodium IEA
Inferred from Electronic Annotation
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cyclin-dependent-like kinase 5
Names
TPKII catalytic subunit
cell division protein kinase 5
serine/threonine-protein kinase PSSALRE
tau protein kinase II catalytic subunit
NP_543161.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080885.1NP_543161.1  cyclin-dependent-like kinase 5

    See identical proteins and their annotated locations for NP_543161.1

    Status: PROVISIONAL

    Source sequence(s)
    L02121
    UniProtKB/Swiss-Prot
    Q03114
    Related
    ENSRNOP00000011052, ENSRNOT00000011052
    Conserved Domains (2) summary
    cd07839
    Location:3286
    STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
    PLN00009
    Location:1288
    PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    7282945..7287427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    6369255..6373737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)