STK35 serine/threonine kinase 35 [Homo sapiens] - Gene

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Summary

Official Symbol: STK35provided by HGNC
Official Full Name: serine/threonine kinase 35provided by HGNC
Primary source: HGNC:16254
See related: Ensembl:ENSG00000125834; HPRD:11612; MIM:609370; Vega:OTTHUMG00000031688
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLIK1; STK35L1
Summary: The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20p13

Sequence :: Chromosome: 20; NC_000020.10 (2082528..2129201)

See STK35 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

constitutive overexpression of STK35 proteins enhances caspase-independent cell death under oxidative stress conditions.
Title: Nuclear retention of importin α coordinates cell fate through changes in gene expression.
by regulating CDKN2A and inhibiting G1- to S-phase transition STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells
Title: STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells.
analysis of the STK35L proteins in human and in sea squirts
Title: Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.
results establish the CLP-36 PDZ-LIM protein as an adapter, recruiting the Clik1 kinase to actin stress fibers in nonmuscle cells, and suggest that Clik1 represents a novel regulator of actin stress fibers
Title: Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_543026.1	NP_066272.1	PDLIM1	BIND	PubMed	CLP-36 interacts with CLIK1.
NP_543026.1	NP_543026.1	STK35	BIND	PubMed	CLIK1 autophosphorylates.
Q8TDR2	O00238	BMPR1B	HPRD	PubMed
Q8TDR2	O00151	PDLIM1	HPRD	PubMed
Q8TDR2	Q13485	SMAD4	HPRD	PubMed
Q8TDR2	Q9HCE7	SMURF1	HPRD	PubMed
Q8TDR2	Q8TDR2	STK35	HPRD	PubMed
Q8TDR2	P36897	TGFBR1	HPRD	PubMed
BioGRID:126760	BioGRID:114572	PDLIM1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:126760	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase 35

Names: serine/threonine-protein kinase 35; CLIK-1; CLP-36 interacting kinase; CLP-36-interacting kinase 1; PDLIM1-interacting kinase 1; serine threonine kinase 35 long form; serine/threonine-protein kinase 35 L1

NP_543026.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080836.3 → NP_543026.2 serine/threonine-protein kinase 35

Status: REVIEWED

Source sequence(s)

AL359916, BC140884, GQ281297

Consensus CDS

CCDS13024.2

UniProtKB/Swiss-Prot

Q8TDR2

Related

ENSP00000370891, OTTHUMP00000030006, ENST00000381482, OTTHUMT00000077574

Conserved Domains (2) summary

cd00180
Location:208 – 523
Blast Score: 451

PKc; Catalytic domain of Protein Kinases

smart00220
Location:202 – 523
Blast Score: 460

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

2082528..2129201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

2031940..2078604

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL359916.8	CAI15590.1
genomic	CH471133.3	EAX10603.1
mRNA	AF195026.1	AAL99353.1
mRNA	AK024394.1	None
mRNA	AK026555.1	None
mRNA	AK302629.1	BAG63871.1
mRNA	AK314728.1	BAG37270.1
mRNA	AL040176.1	None
mRNA	BC017340.2	AAH17340.2
mRNA	BC111573.1	AAI11574.1
mRNA	BC140883.1	AAI40884.1
mRNA	BC140884.1	AAI40885.1
mRNA	GQ281297.1	ACU33925.1