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WFDC6 WAP four-disulfide core domain 6 [ Homo sapiens (human) ]

Gene ID: 140870, updated on 26-Jun-2016
Official Symbol
WFDC6provided by HGNC
Official Full Name
WAP four-disulfide core domain 6provided by HGNC
Primary source
HGNC:HGNC:16164
See related
Ensembl:ENSG00000243543 HPRD:15677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WAP6; C20orf171; HEL-S-295; dJ461P17.11
Summary
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]
Orthologs
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (45534197..45539495, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44162836..44168134, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987282 Neighboring gene ribosomal protein L5 pseudogene 2 Neighboring gene serine peptidase inhibitor, Kunitz type 3 Neighboring gene EPPIN-WFDC6 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 21 Neighboring gene epididymal peptidase inhibitor

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Readthrough EPPIN-WFDC6

Readthrough gene: EPPIN-WFDC6, Included gene: EPPIN

Homology

Clone Names

  • MGC126649, MGC126653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
WAP four-disulfide core domain protein 6
Names
epididymis secretory protein Li 295
protease inhibitor WAP6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080827.1NP_543017.1  WAP four-disulfide core domain protein 6 precursor

    See identical proteins and their annotated locations for NP_543017.1

    Status: REVIEWED

    Source sequence(s)
    AF411861
    Consensus CDS
    CCDS13358.1
    UniProtKB/Swiss-Prot
    Q9BQY6
    UniProtKB/TrEMBL
    A0A0K0K1K0
    Related
    ENSP00000361755, OTTHUMP00000043709, ENST00000372670, OTTHUMT00000107008
    Conserved Domains (1) summary
    pfam00095
    Location:3271
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

    Range
    45534197..45539495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    44065402..44070698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)