Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Myh7provided by MGI
Official Full Name: myosin, heavy polypeptide 7, cardiac muscle, betaprovided by MGI
Primary source: MGI:2155600
Locus tag: RP23-171A13.1
See related: Ensembl:ENSMUSG00000053093; Vega:OTTMUSG00000016385
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-MHC; Myhcb; MyHC-I; Myhc-b; beta-MHC

Genomic context

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Location :: 14 C3; 14 28.01 cM

Sequence :: Chromosome: 14; NC_000080.6 (54970688..54994549, complement)

See Myh7 in Epigenomics, MapViewer

Chromosome 14 - NC_000080.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reexpression of bMHC is associated at the bMHC promoter with increased H3ac but not H3K4me3.
Title: Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.
Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase-dependent.
Title: Sepsis-induced myocardial depression is associated with transcriptional changes in energy metabolism and contractile related genes: a physiological and gene expression-based approach.
the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform.
Title: Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.
Simultaneous defects in MHC7 & TnI accelerate onset & progression of familial hypertrophic cardiomyopathy. Compared with single-mutant models, double-mutant mice develop severe disease & premature death, progressing directly to a dilated phenotype.
Title: Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic cardiomyopathy.
residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity
Title: Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart.

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Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Reporter) (1) 1 citation

Pathways from BioSystems

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Cardiac muscle contraction, organism-specific biosystem (from KEGG)
Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Cardiac muscle contraction, conserved biosystem (from KEGG)
Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
Dilated cardiomyopathy, conserved biosystem (from KEGG)
Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
Striated Muscle Contraction, organism-specific biosystem
Striated Muscle Contraction
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

General gene information

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Markers

Myh7 (e-PCR), detects polymorphism
- UniSTS:532517

Myh7 (e-PCR), detects polymorphism
- UniSTS:463417

Myhcb (e-PCR), detects polymorphism
- UniSTS:143962

Myh7 (e-PCR), detects polymorphism
- UniSTS:265580

RH140569 (e-PCR)
- UniSTS:222638

Myh7 (e-PCR), detects polymorphism
- UniSTS:530876

MARC_5445-5446:996690391:1 (e-PCR)
- UniSTS:269515

Homology

Homologs of the Myh7 gene: The Myh7 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, and zebrafish.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	ISO Inferred from Sequence Orthology more info
ATPase activity	ISO Inferred from Sequence Orthology more info
actin binding	IEA Inferred from Electronic Annotation more info
actin-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
microfilament motor activity	ISO Inferred from Sequence Orthology more info
motor activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
structural constituent of muscle	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
ATP catabolic process	ISO Inferred from Sequence Orthology more info
adult heart development	ISO Inferred from Sequence Orthology more info
muscle contraction	ISO Inferred from Sequence Orthology more info
muscle filament sliding	ISO Inferred from Sequence Orthology more info
regulation of heart rate	ISO Inferred from Sequence Orthology more info
ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Z disc	IDA Inferred from Direct Assay more info
cytoplasm	ISO Inferred from Sequence Orthology more info
focal adhesion	ISO Inferred from Sequence Orthology more info
muscle myosin complex	ISO Inferred from Sequence Orthology more info
myofibril	IDA Inferred from Direct Assay more info	PubMed
myosin complex	IDA Inferred from Direct Assay more info	PubMed
myosin filament	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info
stress fiber	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: myosin-7

Names: myosin-7; myHC-beta; myHC-slow; MYH-beta/slow; myosin heavy chain 7; cardiac myosin heavy chain beta; myosin heavy chain slow isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, cardiac muscle beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080728.2 → NP_542766.1 myosin-7

Status: PROVISIONAL

Source sequence(s)

CT025533

Consensus CDS

CCDS27106.1

UniProtKB/TrEMBL

B2RXX9

UniProtKB/Swiss-Prot

Q91Z83

Related

ENSMUSP00000099867, OTTMUSP00000017626, ENSMUST00000102803, OTTMUST00000039449

Conserved Domains (4) summary

cd01377
Location:81 – 777
Blast Score: 3208

MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...

pfam02736
Location:34 – 75
Blast Score: 177

Myosin_N; Myosin N-terminal SH3-like domain

pfam01576
Location:1068 – 1926
Blast Score: 2041

Myosin_tail_1; Myosin tail

smart00242
Location:80 – 778
Blast Score: 2606

MYSc; Myosin. Large ATPases.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000080.6 Reference GRCm38.p1 C57BL/6J

Range

54970688..54994549, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

NW_001033783.1 Alternate Mm_Celera

Range

29..1258, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01156608.1 (29..1258)	None
genomic	AC157212.2 (19290..43013)	None
genomic	CT025533.11 (24127..47989)	None
mRNA	AJ223362.1	CAB40362.1	C57BL/10
mRNA	AK040973.1	None	C57BL/6J
mRNA	AK137508.1	None	C57BL/6J
mRNA	AK147031.1	BAE27623.1	C57BL/6J
mRNA	AK157742.1	BAE34176.1	C57BL/6J
mRNA	AK168593.1	None	C57BL/6J
mRNA	AK168677.1	BAE40526.1	C57BL/6J
mRNA	AK169198.1	BAE40973.1	C57BL/6J
mRNA	AK169371.1	BAE41119.1	C57BL/6J
mRNA	AY056464.1	AAL17913.1	FVB
mRNA	BC121789.1	AAI21790.1
mRNA	BC158018.1	AAI58019.1
mRNA	BC158070.1	AAI58071.1
mRNA	DQ231556.1	ABB70181.1	C57BL/6
mRNA	DQ231557.1	ABB70182.1	C57BL/6
mRNA	M74752.1	None	AKR