Fabp3 fatty acid binding protein 3, muscle and heart [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Fabp3provided by MGI
Official Full Name: fatty acid binding protein 3, muscle and heartprovided by MGI
Primary source: MGI:95476
Locus tag: RP23-462N15.1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mdgi; Fabph1; Fabph4; H-FABP; Fabph-1; Fabph-4

Genomic context

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Location :: 4 D2.2; 4 63.43 cM

Sequence :: Chromosome: 4; NC_000070.6 (130308778..130315463)

See Fabp3 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

FABP3 overexpression has a detrimental effect on mitochondrion function in embryonic cancer P19 cells.
Title: Overexpression of FABP3 promotes apoptosis through inducing mitochondrial impairment in embryonic cancer cells.
Results indicated that FABP3 knockdown promoted apoptosis and caused mitochondrial dysfunction in P19 cells.
Title: Silencing of FABP3 promotes apoptosis and induces mitochondrion impairment in embryonic carcinoma cells.
These results suggest that FABP3 stimulates glucose uptake by facilitating AMPK-dependent AS160 phosphorylation in skeletal muscle.
Title: Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells.
FABP3, is essential for cold tolerance and efficient fatty acid oxidation in mouse brown adipose tissue
Title: Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.
results revealed discrete localization of H-FABP and B-FABP in different supporting, not receptor, cell populations of the cochlea of adult mouse
Title: Localization of fatty acid binding proteins (FABPs) in the cochlea of mice.
Together, H-FABP is highly expressed in ACh interneurons and glutamatergic terminals, thereby regulating dopamine D2R function in the striatum.
Title: Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain.
Serum H-FABP and leptin increased simultaneously and significantly in the patients, and leptin alleviated pulmonary and intestinal injuries by restraining tissue H-FABP secretions in the mouse model of sepsis
Title: Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels.
Cardiac insulin resistance and glucose uptake is largely corrected by a reduction in FABP3 in vivo without contemporaneous deleterious effects on cardiac function.
Title: Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle.
These results indicate that the induction of FABP3 in brown adipose tissue correlates with an increased demand for adaptive thermogenesis in rodents.
Title: Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents.
H-FABP expression influences brain 20:4n-6 uptake and trafficking as well as steady-state brain lipid levels
Title: Brain arachidonic acid incorporation is decreased in heart fatty acid binding protein gene-ablated mice.

Submit: New GeneRIF Correction See all (19)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1)
Targeted (knock-out) (2) 1 citation
Gene trapped (1)

Pathways from BioSystems

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PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
PPAR (Peroxisome proliferator-activated receptor) signaling pathway
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...

General gene information

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Markers

Fabp3 (e-PCR), detects polymorphism
- UniSTS:498469

Fabp3 (e-PCR), detects polymorphism
- UniSTS:498376

U02884 (e-PCR)
- UniSTS:125642

Fabp3 (e-PCR), detects polymorphism
- UniSTS:143061

Fabp3 (e-PCR), detects polymorphism
- UniSTS:143062

Homology

Homologs of the Fabp3 gene: The Fabp3 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
fatty acid binding	ISO Inferred from Sequence Orthology more info
icosatetraenoic acid binding	ISO Inferred from Sequence Orthology more info
lipid binding	IEA Inferred from Electronic Annotation more info
long-chain fatty acid transporter activity	ISO Inferred from Sequence Orthology more info
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
phosphatidylcholine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fatty acid-binding protein, heart

Names: fatty acid-binding protein, heart; fatty acid-binding protein 3; mammary-derived growth inhibitor; fatty acid binding protein heart 1; fatty acid binding protein heart 4; heart-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010174.1 → NP_034304.1 fatty acid-binding protein, heart

Status: PROVISIONAL

Source sequence(s)

U02883

Consensus CDS

CCDS18709.1

UniProtKB/Swiss-Prot

P11404

UniProtKB/TrEMBL

Q5EBJ0

Conserved Domains (1) summary

pfam00061
Location:6 – 119
Blast Score: 167

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p1 C57BL/6J

Range

130308778..130315463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 NOD/MrkTac

Genomic

NT_187023.1 Reference GRCm38.p1 NOD/MrkTac

Range

1910262..1916947

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

128641729..128648414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01040384.1 (2441..9126)	None
genomic	AL772297.10 (36927..43612)	None	ZRU
genomic	CH466552.2	EDL30140.1	mixed
genomic	CU407307.5 (41919..48604)	None	ZRU
genomic	U02884.1	AAA61933.1	ICR x Swiss
mRNA	AK142156.1	BAE24952.1	C57BL/6J
mRNA	BC002082.1	AAH02082.1
mRNA	BC089542.1	AAH89542.1
mRNA	U02883.1	AAA03445.1	BALB/c
mRNA	X14961.1	CAA33084.1