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    Sec63 SEC63-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 140740, updated on 11-May-2013
    Official Symbol
    Sec63provided by MGI
    Official Full Name
    SEC63-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:2155302
    See related
    Ensembl:ENSMUSG00000019802; Vega:OTTMUSG00000019467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI649014; AW319215; 5730478J10Rik
    Location :
    10 B2; 10 22.89 cM
    Sequence :
    Chromosome: 10; NC_000076.6 (42761496..42832514)
    See Sec63 in Epigenomics, MapViewer

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5036 Neighboring gene osteopetrosis associated transmembrane protein 1 Neighboring gene sex comb on midleg-like 4 (Drosophila) Neighboring gene predicted gene 5079

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059.
    2. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Fedeles SV, et al. Nat Genet, 2011 Jun 19. PMID 21685914.
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    4. The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice. Su RW, et al. Reprod Biol Endocrinol, 2009 Feb 11. PMID 19208265.
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.

    See all (23) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
      Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
    2. SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.
      Title: The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Protein export, organism-specific biosystem (from KEGG)
      Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein export, conserved biosystem (from KEGG)
      Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    liver development IGI
    Inferred from Genetic Interaction
    more info
    		  
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    multicellular organismal aging IMP
    Inferred from Mutant Phenotype
    more info
    		  
    nitrogen compound metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		  
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    renal system development IGI
    Inferred from Genetic Interaction
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    translocation protein SEC63 homolog
    Names
    translocation protein SEC63 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153055.3 → NP_694695.3  translocation protein SEC63 homolog

      Status: VALIDATED

      Source sequence(s)
      AY024346, BC059816, BF472596
      Consensus CDS
      CCDS23815.1
      UniProtKB/Swiss-Prot
      Q8VHE0
      Related
      ENSMUSP00000019937, OTTMUSP00000020993, ENSMUST00000019937, OTTMUST00000046488
      Conserved Domains (4) summary
      cd06257
      Location:104 – 154
      Blast Score: 177
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam04889
      Location:563 – 626
      Blast Score: 91
      Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein
      smart00611
      Location:209 – 490
      Blast Score: 535
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins.
      smart00973
      Location:238 – 476
      Blast Score: 197
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p1 C57BL/6J

      Range
      42761496..42832514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      43628635..43699289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01085074.1 (1712..2122) None
    genomic AAHY01085075.1 None
    genomic AAHY01085076.1 None
    genomic AAHY01085077.1 None
    genomic AAHY01085078.1 None
    genomic AC124998.10 (12180..79741) None
    genomic CH466540.1 EDL05007.1 mixed
    mRNA AF397910.1 None
    mRNA AK017703.1 None C57BL/6J
    mRNA AK036629.1 None C57BL/6J
    mRNA AK049737.1 None C57BL/6J
    mRNA AK090248.1 None C57BL/6J
    mRNA AK163813.1 None C57BL/6J
    mRNA AK180295.1 None
    mRNA AY024346.1 AAK00580.1 C57BL/6J
    mRNA AY238936.1 AAO88962.1 ICR
    mRNA BC019366.1 AAH19366.1 CZECHII
    mRNA BC029774.1 AAH29774.1 FVB/N
    mRNA BC031846.1 AAH31846.1 CZECHII
    mRNA BC059816.1 None C57BL/6
    mRNA BC080810.1 None
    mRNA BF472596.1 None C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHE0.4 GenPept UniProtKB/Swiss-Prot:Q8VHE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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