Display Settings:

Format

Send to:

Choose Destination

UBE2F ubiquitin-conjugating enzyme E2F (putative) [ Homo sapiens (human) ]

Gene ID: 140739, updated on 28-Aug-2014
Official Symbol
UBE2Fprovided by HGNC
Official Full Name
ubiquitin-conjugating enzyme E2F (putative)provided by HGNC
Primary source
HGNC:12480
See related
Ensembl:ENSG00000184182; HPRD:14812; Vega:OTTHUMG00000133341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCE2
See UBE2F in Epigenomics, MapViewer
Location:
2q37.3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (237966945..238042782)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238875587..238951423)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 44 Neighboring gene receptor (G protein-coupled) activity modifying protein 1 Neighboring gene UBE2F-SCLY readthrough (NMD candidate) Neighboring gene selenocysteine lyase Neighboring gene espin-like

Protein interactions

Protein Gene Interaction Pubs
Vif vif The conjugation of NEDD8 to Cullin-5 by UBE2F is required for HIV-1 Vif-mediated A3G degradation PubMed
vif The active site proximal loop extension (residues 124-129) in UBE2F is critical for HIV-1 Vif-mediated A3G degradation PubMed
vif UBE2F and RBX2 are required for activation of the polyubiquitin synthesis activity of Vif/CBF-beta/CUL5, leading to HIV-1 Vif-mediated degradation of A3G in cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC18120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NEDD8 ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
protein neddylation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NEDD8-conjugating enzyme UBE2F
Names
NEDD8-conjugating enzyme UBE2F
NEDD8 protein ligase UBE2F
NEDD8-conjugating enzyme 2
NEDD8 carrier protein UBE2F
NP_001265234.1
NP_001265235.1
NP_001265236.1
NP_001265237.1
NP_542409.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278305.1NP_001265234.1  NEDD8-conjugating enzyme UBE2F isoform 1

    See proteins identical to NP_001265234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK294107, CN370973, CN370974, DA140546, DB118122
    Consensus CDS
    CCDS2523.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000478474, ENST00000612130
    Conserved Domains (1) summary
    cd00195
    Location:35180
    Blast Score: 329
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001278306.1NP_001265235.1  NEDD8-conjugating enzyme UBE2F isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1 and has a distinct N-terminus.
    Source sequence(s)
    AK294107, BM470609, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63175.1
    UniProtKB/TrEMBL
    H9KVB9
    UniProtKB/Swiss-Prot
    Q969M7
    Conserved Domains (1) summary
    cd00195
    Location:16156
    Blast Score: 308
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_001278307.1NP_001265236.1  NEDD8-conjugating enzyme UBE2F isoform 3

    See proteins identical to NP_001265236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK297502, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63177.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000399183, ENST00000414443
    Conserved Domains (1) summary
    cd00195
    Location:35148
    Blast Score: 286
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_001278308.1NP_001265237.1  NEDD8-conjugating enzyme UBE2F isoform 4

    See proteins identical to NP_001265237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK294107, BQ959565, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63176.1
    UniProtKB/TrEMBL
    C9J212
    UniProtKB/Swiss-Prot
    Q969M7
    Conserved Domains (1) summary
    cd00195
    Location:35149
    Blast Score: 276
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. NM_080678.2NP_542409.1  NEDD8-conjugating enzyme UBE2F isoform 1

    See proteins identical to NP_542409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK290063, AK294107, BC010549, BX421077, CN370973
    Consensus CDS
    CCDS2523.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000272930, OTTHUMP00000164480, ENST00000272930, OTTHUMT00000257171
    Conserved Domains (1) summary
    cd00195
    Location:35180
    Blast Score: 329
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. NR_103498.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294107, BX421077, CN370973, CN370974
  2. NR_103499.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303094, BQ959565, BX421077, CN370973, CN370974
  3. NR_103500.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294107, BM920749, BX421077, CN370973, CN370974

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    237966945..238042782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    230667560..230743407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    238881335..238957233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)