Format

Send to:

Choose Destination

F5 coagulation factor V [ Mus musculus (house mouse) ]

Gene ID: 14067, updated on 8-May-2016
Official Symbol
F5provided by MGI
Official Full Name
coagulation factor Vprovided by MGI
Primary source
MGI:MGI:88382
See related
Ensembl:ENSMUSG00000026579 Vega:OTTMUSG00000034808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cf5; Cf-5; AI173222
Summary
This gene encodes a glycoprotein coagulation factor that plays a critical role in the process of blood coagulation and hemostasis. The encoded protein is activated by thrombin, to generate a heterodimer containing heavy and light chains held together by calcium ions. About half of the mice lacking the encoded protein die at an embryonic stage possible due to abnormal yolk-sac vasculature while the remaining animals succumbed to massive hemorrhage immediately after birth. A point mutation in this gene has been shown to cause disseminated intravascular thrombosis in the perinatal period, resulting in frequent deaths of newborn mice. [provided by RefSeq, Apr 2015]
Orthologs
Location:
1 H2.2; 1 71.46 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (164151859..164220274)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (166081990..166150405)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene selectin, lymphocyte Neighboring gene selectin, platelet Neighboring gene predicted gene 16548 Neighboring gene solute carrier family 19 (thiamine transporter), member 2 Neighboring gene coiled-coil domain containing 181

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation ISO
Inferred from Sequence Orthology
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
coagulation factor V
Names
activated protein C cofactor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007976.3NP_032002.1  coagulation factor V preproprotein

    See identical proteins and their annotated locations for NP_032002.1

    Status: REVIEWED

    Source sequence(s)
    AC105161, AC157771, AK137521, AK137537, BB799410
    Consensus CDS
    CCDS35754.1
    UniProtKB/Swiss-Prot
    O88783
    Related
    ENSMUSP00000083204, OTTMUSP00000048218, ENSMUST00000086040, OTTMUST00000088478
    Conserved Domains (4) summary
    cd00057
    Location:20272179
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd14450
    Location:347526
    CuRO_3_FV_like; The third cupredoxin domain of coagulation factor V and similar proteins
    cd14454
    Location:539682
    CuRO_4_FV_like; The fourth cupredoxin domain of coagulation factor V and similar proteins
    cl19115
    Location:15391714
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    164151859..164220274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    166589960..166658650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)