Rxfp2 relaxin/insulin-like family peptide receptor 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Rxfp2provided by MGI
Official Full Name: relaxin/insulin-like family peptide receptor 2provided by MGI
Primary source: MGI:2153463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lgr8; Great; Gpr106

Genomic context

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Location :: 5 G3; 5 89.23 cM

Sequence :: Chromosome: 5; NC_000071.6 (150018675..150082186)

See Rxfp2 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Prenatal exposure to diethylstilbestrol increased the expression of LGR8 mRNA in the mouse gubernaculum testis.
Title: [Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis].
A deficiency for Rxfp2 on Cav1-deficient background led to more than a 2-fold increase in the incidence of uterine cysts.
Title: Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2.
A mouse model was created containing a novel missense mutation in Relaxin/insulin-like family peptide receptor 2 which likely prevents binding to its ligand, Insulin-like peptide 3, resulting in failure of the transabdominal phase of testicular descent.
Title: A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.
RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent.
Title: The role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice.
The data suggest that Pod1 may negatively regulate Rxfp2 expression in the developing glomerulus to promote cell proliferation.
Title: Regulation of Rxfp2 (Lgr8) expression in the mouse fetal kidney by the transcription factor Pod1 (Tcf 21).
Rxfp2-deficient mice showed decreased bone mass, mineralizing surface, bone formation, and osteoclast surface.
Title: New roles for INSL3 in adults.
Rxfp2 gene expression at different stages of embryonic and postnatal mouse development in male reproductive tissues was examined
Title: Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs.
Disruption of the Greatgene causes failure of the transabdominal phase of descent, identical to that seen in the Insl3-deficient mutants, consistent with the recent data suggesting that Great gene encodes the Insl3 transmembrane receptor.
Title: Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.
neither Insl3 nor Lgr8 contribute to the RLN signaling pathway; Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo
Title: Genetic targeting of relaxin and insulin-like factor 3 receptors in mice.
Insulin-like 3 peptide or great cause cryptorchidism (undescended testes) in mice.
Title: GREAT/LGR8 is the only receptor for insulin-like 3 peptide.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (2) 1 citation
Chemically induced (ENU) (1) 1 citation

Pathways from BioSystems

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Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Relaxin receptors, organism-specific biosystem (from REACTOME)
Relaxin receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Gpr106 (e-PCR), detects polymorphism
- UniSTS:234014

NoName (e-PCR)
- UniSTS:224604

Rxfp2 (e-PCR), detects polymorphism
- UniSTS:527529

Homology

Homologs of the Rxfp2 gene: The Rxfp2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and fruit fly.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
peptide hormone binding	ISO Inferred from Sequence Orthology more info
protein-hormone receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
adenylate cyclase-activating G-protein coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
oocyte maturation	ISO Inferred from Sequence Orthology more info
positive regulation of cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: relaxin receptor 2

Names: relaxin receptor 2; G protein-coupled receptor 106; G-protein coupled receptor 106; relaxin family peptide receptor 2; G protein coupled receptor affecting testicular descent; G-protein coupled receptor affecting testicular descent; leucine-rich repeat-containing G protein-coupled receptor 8; leucine-rich repeat-containing G-protein coupled receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080468.2 → NP_536716.2 relaxin receptor 2 precursor

Status: VALIDATED

Source sequence(s)

AF346501, AK039086, BC120741, CJ243198

Consensus CDS

CCDS19886.1

UniProtKB/Swiss-Prot

Q91ZZ5

Conserved Domains (4) summary

cd00112
Location:28 – 63
Blast Score: 142

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl15309
Location:88 – 286
Blast Score: 105

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam00001
Location:506 – 674
Blast Score: 179

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:146 – 204
Blast Score: 166

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

150018675..150082186

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

148024761..148088307

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01050983.1 (13291..76837)	None
genomic	AC077689.9 (39734..102395)	None
genomic	CH466614.1	EDL05874.1	mixed
mRNA	AF346501.1	AAL08943.1	C57BL/6
mRNA	AK034592.1	BAC28765.1	C57BL/6J
mRNA	AK039086.1	None	C57BL/6J
mRNA	AK047861.1	BAC33177.1	C57BL/6J
mRNA	BC120741.1	AAI20742.1
mRNA	BC144802.1	AAI44803.1
mRNA	BC144803.1	AAI44804.1
mRNA	CJ243198.1	None	C57BL/6J