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MYL6B myosin light chain 6B [ Homo sapiens (human) ]

Gene ID: 140465, updated on 8-May-2016
Official Symbol
MYL6Bprovided by HGNC
Official Full Name
myosin light chain 6Bprovided by HGNC
Primary source
HGNC:HGNC:29823
See related
Ensembl:ENSG00000196465 HPRD:14721; MIM:609930; Vega:OTTHUMG00000170199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLC1SA
Summary
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Orthologs
Location:
12q13.13
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (56152420..56157987)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56546040..56551771)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene extended synaptotagmin protein 1 Neighboring gene myosin light chain 6 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of muscle TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
muscle filament sliding TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 
myosin complex TAS
Traceable Author Statement
more info
PubMed 
unconventional myosin complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
myosin light chain 6B
Names
myosin alkali light chain 1 slow a
myosin light chain 1 slow a
myosin light chain 1 slow-twitch muscle A isoform
myosin light chain 1, slow-twitch muscle A isoform
myosin, light chain 6B, alkali, smooth muscle and non-muscle
myosin, light polypeptide 6B, alkali, smooth muscle and non-muscle
smooth muscle and non-muscle myosin alkali light chain 6B
smooth muscle and nonmuscle myosin light chain alkali 6B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199629.1NP_001186558.1  myosin light chain 6B

    See identical proteins and their annotated locations for NP_001186558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI349553, BC014400
    Consensus CDS
    CCDS8905.1
    UniProtKB/Swiss-Prot
    P14649
    UniProtKB/TrEMBL
    A0A024RB31
    Related
    ENSP00000446643, OTTHUMP00000243208, ENST00000550443, OTTHUMT00000407917
    Conserved Domains (4) summary
    PTZ00184
    Location:58207
    PTZ00184; calmodulin; Provisional
    smart00054
    Location:6896
    EFh; EF-hand, calcium binding motif
    cd00051
    Location:150205
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:68132
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_002475.4NP_002466.1  myosin light chain 6B

    See identical proteins and their annotated locations for NP_002466.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034102, AI349553, BC014400
    Consensus CDS
    CCDS8905.1
    UniProtKB/Swiss-Prot
    P14649
    UniProtKB/TrEMBL
    A0A024RB31
    Related
    ENSP00000450385, OTTHUMP00000243210, ENST00000553066, OTTHUMT00000407920
    Conserved Domains (4) summary
    PTZ00184
    Location:58207
    PTZ00184; calmodulin; Provisional
    smart00054
    Location:6896
    EFh; EF-hand, calcium binding motif
    cd00051
    Location:150205
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl08302
    Location:68132
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    56152420..56157987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    56513584..56519154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)