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Ewsr1 Ewing sarcoma breakpoint region 1 [ Mus musculus (house mouse) ]

Gene ID: 14030, updated on 28-May-2016
Official Symbol
Ewsr1provided by MGI
Official Full Name
Ewing sarcoma breakpoint region 1provided by MGI
Primary source
MGI:MGI:99960
See related
Ensembl:ENSMUSG00000009079 Vega:OTTMUSG00000005079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ews; Ewsh
Orthologs
Location:
11; 11 A1-A3
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (5069687..5099099, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4969691..4999080, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene neurofilament, heavy polypeptide Neighboring gene adaptor protein complex AP-1, beta 1 subunit Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene predicted gene, 39572 Neighboring gene ribosomal protein, large, P0 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
RNA-binding protein EWS
Names
Ewing sarcoma homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283061.1NP_001269990.1  RNA-binding protein EWS isoform 1

    See identical proteins and their annotated locations for NP_001269990.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI852718, BC068226, BY272748, CB205713
    UniProtKB/TrEMBL
    Q6NVA3
    Conserved Domains (4) summary
    smart00360
    Location:363442
    RRM; RNA recognition motif
    cd12533
    Location:361444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:518547
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:522543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. NM_001283062.1NP_001269991.1  RNA-binding protein EWS isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI852718, AK049743, AL645845, BY272748
    Consensus CDS
    CCDS70131.1
    UniProtKB/TrEMBL
    Q5SUT0
    Related
    ENSMUSP00000073034, OTTMUSP00000005287, ENSMUST00000073308, OTTMUST00000011346
    Conserved Domains (4) summary
    smart00360
    Location:325404
    RRM; RNA recognition motif
    cd12533
    Location:323406
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:480509
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:484505
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  3. NM_001283063.1NP_001269992.1  RNA-binding protein EWS isoform 4

    See identical proteins and their annotated locations for NP_001269992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AK147909, BY272748
    UniProtKB/TrEMBL
    Q3UGI7
  4. NM_007968.3NP_031994.2  RNA-binding protein EWS isoform 2

    See identical proteins and their annotated locations for NP_031994.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AI852718, AK151625, BY272748, CB205713
    Consensus CDS
    CCDS24396.1
    UniProtKB/Swiss-Prot
    Q61545
    Related
    ENSMUSP00000078867, OTTMUSP00000005285, ENSMUST00000079949, OTTMUST00000011341
    Conserved Domains (4) summary
    smart00360
    Location:362441
    RRM; RNA recognition motif
    cd12533
    Location:360443
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:517546
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:521542
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    5069687..5099099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514510.2XP_006514573.1  

    Conserved Domains (4) summary
    smart00360
    Location:363442
    RRM; RNA recognition motif
    cd12533
    Location:361444
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:518547
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:522543
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  2. XM_006514512.2XP_006514575.1  

    UniProtKB/TrEMBL
    Q5SUS9
    Related
    ENSMUSP00000099994, OTTMUSP00000005288, ENSMUST00000102930, OTTMUST00000011348
    Conserved Domains (4) summary
    smart00360
    Location:368447
    RRM; RNA recognition motif
    cd12533
    Location:366449
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:523552
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:527548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  3. XM_006514509.2XP_006514572.1  

    Conserved Domains (4) summary
    smart00360
    Location:368447
    RRM; RNA recognition motif
    cd12533
    Location:366449
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:523552
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:527548
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  4. XM_006514511.2XP_006514574.1  

    Conserved Domains (4) summary
    smart00360
    Location:369448
    RRM; RNA recognition motif
    cd12533
    Location:367450
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:524553
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:528549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  5. XM_006514508.2XP_006514571.1  

    Conserved Domains (4) summary
    smart00360
    Location:369448
    RRM; RNA recognition motif
    cd12533
    Location:367450
    RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
    pfam00641
    Location:524553
    zf-RanBP; Zn-finger in Ran binding protein and others
    sd00025
    Location:528549
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  6. XM_006514513.2XP_006514576.1  

    UniProtKB/TrEMBL
    Q5SUS8
    Related
    ENSMUSP00000091057, OTTMUSP00000005286, ENSMUST00000093365, OTTMUST00000011343
    Conserved Domains (1) summary
    PRK14949
    Location:10135
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional

RNA

  1. XR_380958.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    5566576..5596184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)