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    CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like [ Homo sapiens ]

    Gene ID: 1399, updated on 19-May-2012
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    Summary

    Official Symbol
    CRKLprovided by HGNC
    Official Full Name
    v-crk sarcoma virus CT10 oncogene homolog (avian)-likeprovided by HGNC
    Primary source
    HGNC:2363
    See related
    Ensembl:ENSG00000099942; HPRD:03596; MIM:602007; Vega:OTTHUMG00000150807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
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    Genomic context

    Location :
    22q11.21
    Sequence :
    Chromosome: 22; NC_000022.10 (21271714..21308037)
    See CRKL in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha Neighboring gene serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Neighboring gene synaptosomal-associated protein, 29kDa Neighboring gene apoptosis-inducing factor, mitochondrion-associated, 3 Neighboring gene leucine-zipper-like transcription regulator 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion. Yanagi H, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22244889.
    2. Recurrent amplification in the 22q11 region in laryngeal squamous cell carcinoma results in overexpression of the CRKL but not the MAPK1 oncogene. Kostrzewska-Poczekaj M, et al. Cancer Biomark, 2010-2011. PMID 21896986.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer. Padmanabhan RA, et al. Mol Endocrinol, 2011 Sep. PMID 21700719.
    5. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. He Y, et al. J Cell Sci, 2011 Jul 1. PMID 21628423.

    See all (106) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. these results indicate that CRKL regulates HNSCC-cell growth, motility, and integrin-dependent cell adhesion, suggesting that CRKL plays a principal role in HNSCC tumorigenicity.
      Title: CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion.
    2. The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer.
      Title: CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.
    3. Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge
      Title: The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge.
    4. These results suggest that CRKL, but not MAPK1 is the target oncogene of the rare but recurrent amplification at 22q11.2 in laryngeal squamous cell carcinoma.
      Title: Recurrent amplification in the 22q11 region in laryngeal squamous cell carcinoma results in overexpression of the CRKL but not the MAPK1 oncogene.
    5. differential binding selectivity of Crk and CrkL to their downstream partners Dock 180 and C3G was demonstrated in ovarian cancer cell line SKOV3 through coimmunoprecipitation
      Title: Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma.
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    8. Findings indicate that amplification and resultant overexpression of CRKL contribute to diverse oncogenic phenotypes in lung cancer.
      Title: Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.
    9. an interaction between the regulatory subunit of PI3K, p85, and the adaptor protein CrkL is required for efficient NKG2D-mediated cellular cytotoxicity
      Title: PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion.
    10. CRKL permits cells to bypass the strict need for adhesion in response to FGF8 through direct interaction with receptor.
      Title: Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
    Submit: New GeneRIF Correction See all (25)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005198.1 DNM2    BIND  PubMed An unspecified isoform of Dyn2 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human Dyn2 and CrkL from an unspecified species. 
    NP_005198.1 NP_009112.1 MAP4K1    BIND  PubMed HPK1, a Ste-20 homologous serine/threonine kinase phosphorylates CrkL, a Crk-like adaptor protein 
    NP_005198.1 RAPGEF1    BIND  PubMed Crk-L interacts with C3G. 
    NP_005198.1 NP_003168.2 SYK    BIND  PubMed CrkL interacts with Syk. 
    NP_005198.1 NP_000368.1 WAS    BIND  PubMed CrkL interacts with WASP. 
    NP_005198.1 NP_003378.3 WIPF1    BIND  PubMed WIP interacts with CrkL. 
    NP_005198.1 NP_001070.2 ZAP70    BIND  PubMed ZAP-70 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species. 
    P46109 P00519 ABL1    HPRD  PubMed  
    P46109 RICS ARHGAP32    HPRD  PubMed  
    P46109 P56945 BCAR1    HPRD  PubMed  
    P46109 P11274 BCR    HPRD  PubMed  
    P46109 Q8WV28 BLNK    HPRD  PubMed  
    P46109 P22681 CBL    HPRD  PubMed  
    P46109 Q13191 CBLB    HPRD  PubMed  
    P46109 P28906 CD34    HPRD  PubMed  
    P46109 P46108 CRK    HPRD  PubMed  
    P46109 O75553 DAB1    HPRD  PubMed  
    P46109 Q92608 DOCK2    HPRD  PubMed  
    P46109 Q99704 DOK1    HPRD  PubMed  
    P46109 O15197 EPHB6    HPRD  PubMed  
    P46109 P19235 EPOR    HPRD  PubMed  
    P46109 Q9UI08 EVL    HPRD  PubMed  
    P46109 P12314 FCGR1A    HPRD  PubMed  
    P46109 Q13480 GAB1    HPRD  PubMed  
    P46109 Q9UQC2 GAB2    HPRD  PubMed  
    P46109 P62993 GRB2    HPRD  PubMed  
    P46109 P17181 IFNAR1    HPRD  PubMed  
    P46109 P08069 IGF1R    HPRD  PubMed  
    P46109 O00145 INPP5D    HPRD  PubMed  
    P46109 P06213 INSR    HPRD  PubMed  
    P46109 Insulin receptor substrate 4 IRS4    HPRD  PubMed  
    P46109 P05556 ITGB1    HPRD  PubMed  
    P46109 KIDINS220 KIDINS220    HPRD  PubMed  
    P46109 P10721 KIT    HPRD  PubMed  
    P46109 P07948 LYN    HPRD  PubMed  
    P46109 Q92918 MAP4K1    HPRD  PubMed  
    P46109 Q9Y4K4 MAP4K5    HPRD  PubMed  
    P46109 Q14511 NEDD9    HPRD  PubMed  
    P46109 P16234 PDGFRA    HPRD  PubMed  
    P46109 P27986 PIK3R1    HPRD  PubMed  
    P46109 O00459 PIK3R2    HPRD  PubMed  
    P46109 Q06124 PTPN11    HPRD  PubMed  
    P46109 P49023 PXN    HPRD  PubMed  
    P46109 Q13905 RAPGEF1    HPRD  PubMed  
    P46109 P29353 SHC1    HPRD  PubMed  
    P46109 Q07889 SOS1    HPRD  PubMed  
    P46109 Q07890 SOS2    HPRD  PubMed  
    P46109 P42229 STAT5A    HPRD  PubMed  
    P46109 P51692 STAT5B    HPRD  PubMed  
    P46109 P43405 SYK    HPRD  PubMed  
    P46109 HIC5 TGFB1I1    HPRD  PubMed  
    P46109 P29597 TYK2    HPRD  PubMed  
    P46109 P42768 WAS    HPRD  PubMed  
    P46109 O43516 WIPF1    HPRD  PubMed  
    BioGRID:107789 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107789 BioGRID:106785 ANK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:115091 ARHGAP32    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:107789 BioGRID:107083 BCR    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:107789 BioGRID:118894 BLNK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:107316 CBLB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:107385 CD34    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:108129 DOCK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:108131 DOK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107789 BioGRID:108371 EPOR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:108421 ETV6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:108503 FCGR1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:108824 GAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:115181 GAB2    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Two-hybrid 
    BioGRID:107789 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:109847 INPP5D    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:114048 IRS4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107789 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:116354 MAP4K1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:116353 MAP4K5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:110816 NEDD9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:111182 PDGFRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:107789 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107789 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:111787 PXN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:109146 RAPGEF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:112653 STAT5A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107789 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107789 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107789 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107789 BioGRID:113293 WAS    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHA forward signaling, organism-specific biosystem
      EPHA forward signaling
    • EPO signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      EPO signaling pathway, organism-specific biosystem
      EPO signaling pathway
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • IGF1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      IGF1 pathway, organism-specific biosystem
      IGF1 pathway
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • JNK signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
      JNK signaling in the CD4+ TCR pathway, organism-specific biosystem
      JNK signaling in the CD4+ TCR pathway
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • PDGFR-alpha signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-alpha signaling pathway, organism-specific biosystem
      PDGFR-alpha signaling pathway
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Paxillin-dependent events mediated by a4b1, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-dependent events mediated by a4b1, organism-specific biosystem
      Paxillin-dependent events mediated by a4b1
    • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
      Paxillin-independent events mediated by a4b1 and a4b7
    • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Reelin signaling pathway, organism-specific biosystem
      Reelin signaling pathway
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
      Regulation of signaling by CBL, organism-specific biosystemCbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl negatively regulates PI3...
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    signal transducer activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    JNK cascade TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    parathyroid gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    pattern specification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    thymus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    crk-like protein
    Names
    crk-like protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016354.1 RefSeqGene

      Range
      5001..41324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005207.3 → NP_005198.1  crk-like protein

      Status: REVIEWED

      Source sequence(s)
      AA844269, AC002470, BC043500, X59656
      Consensus CDS
      CCDS13785.1
      UniProtKB/Swiss-Prot
      P46109
      Related
      ENSP00000346300, OTTHUMP00000198538, ENST00000354336, OTTHUMT00000320158
      Conserved Domains (2) summary
      cd00174
      Location:127 – 180
      Blast Score: 180
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd09926
      Location:14 – 106
      Blast Score: 487
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      21271714..21308037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      4539711..4576600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC002470.17 (153101..189277) None
    genomic AL049941.1 None
    genomic CH471176.2 EAX02932.1
      EAX02933.1
      EAX02934.1
    mRNA AA844269.1 None
    mRNA AK000311.1 None
    mRNA AK292909.1 BAF85598.1
    mRNA BC026248.1 None
    mRNA BC033281.1 None
    mRNA BC043500.1 AAH43500.1
    mRNA BC044621.1 None
    mRNA BC053958.1 None
    mRNA CR456423.1 CAG30309.1
    mRNA X59656.1 CAA42199.1
    other-genetic CU012984.1 CAK54415.1
    other-genetic CU013272.1 CAK54714.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46109.1 GenPept UniProtKB/Swiss-Prot:P46109
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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