Esr1 estrogen receptor 1 (alpha) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Esr1provided by MGI
Official Full Name: estrogen receptor 1 (alpha)provided by MGI
Primary source: MGI:1352467
See related: Ensembl:ENSMUSG00000019768; Vega:OTTMUSG00000020886
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERa; ESR; Estr; ER[a]; Estra; Nr3a1; ERalpha; AA420328; AU041214; ER-alpha

Genomic context

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Location :: 10 A1; 10 2.03 cM

Sequence :: Chromosome: 10; NC_000076.6 (4612046..5003761)

See Esr1 in Epigenomics, MapViewer

Chromosome 10 - NC_000076.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Characterize an estradiol-regulated interaction of NPPA with ERalpha in cardiomyocytes.
Title: 17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.
Estrogen receptor alpha activation and the downstream intracellular pathways, regulate nongenomic function and myofilament activation.
Title: Rapid changes in cardiac myofilament function following the acute activation of estrogen receptor-alpha.
propose that the physiological trabecular bone-sparing effect of estrogen is mediated via ERalpha in osteocytes in males, but via ERalpha in osteoclasts in females
Title: Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.
Demonstrate the essential role of E2 and endothelial estrogen receptor alpha in flow-mediated remodeling of resistance arteries in vivo.
Title: Key role of estrogens and endothelial estrogen receptor α in blood flow-mediated remodeling of resistance arteries.
mice with selective deletion of estrogen receptor alpha (ERalpha) from Kiss1 neurons show cellular activity similar to that observed in ovariectomized females
Title: Shift in Kiss1 cell activity requires estrogen receptor α.
In the skin of estrogen receptor alpha -/- mice, collagen content was significantly increased, which correlated with decreased levels of matrix metalloproteinase 15 and with elevated collagen production.
Title: A role for estrogen receptor-α and estrogen receptor-β in collagen biosynthesis in mouse skin.
In the absence of estrogen receptor alpha, estradiol levels increase; other mechanisms (including estrogen receptor beta) maintain hippocampal-dependent memory.
Title: Role of estrogen receptor α and β in preserving hippocampal function during aging.
in females, trabecular and cortical bone volume are critically dependent on the ERalpha regulation of osteoblasts
Title: Inactivation of estrogen receptor α in bone-forming cells induces bone loss in female mice.
Brain NMDA receptors were affected by the deletion of ERs, which affect the response to MPTP and 17beta-oestradiol treatments with brain region specificity.
Title: Effect of oestrogen receptors on brain NMDA receptors of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice.
Estradiol regulates vascular smooth muscle microRNA 203 expression via estrogen receptor alpha.
Title: Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.

Submit: New GeneRIF Correction See all (368)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (10) 1 citation
Targeted (knock-out) (7) 1 citation
Targeted (other) (2) 1 citation
Targeted (knock-in) (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_031982.1	NP_032704.1	Ncoa2	BIND	PubMed	GRIP1 interacts with ER in a hormone-dependent manner. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human ER.
NP_031982.1	AAO60105.1	Pou4f1	BIND	PubMed	DNA-binding domain of ER interacts with the POU domain of Brn-3a-long.
NP_031982.1	AAO60106.1	Pou4f1	BIND	PubMed	DNA-binding domain of ER interacts with the POU domain of Brn-3a-short.
NP_031982.1	AAB30578.1	Pou4f2	BIND	PubMed	DNA-binding domain of ER interacts with the POU domain of Brn-3b-short.
NP_031982.1	NP_620394.2	Pou4f2	BIND	PubMed	DNA-binding domain of ER interacts with the POU domain of Brn-3b-long.
BioGRID:199521	BioGRID:198383	Brca1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:198512	Ctnnb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:200871	Jun	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:230999	Kdm4a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:228758	Kdm4b	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:218326	Kdm4c	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:201137	Lef1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:201708	Ncoa2	BioGRID	PubMed	Two-hybrid
BioGRID:199521	BioGRID:202136	Pgr	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:199521	BioGRID:202310	Pou4f1	BioGRID	PubMed	Two-hybrid
BioGRID:199521	BioGRID:202311	Pou4f2	BioGRID	PubMed	Two-hybrid
BioGRID:199521	BioGRID:202337	Ppp1cc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:112489	SMARCE1	BioGRID	PubMed	Reconstituted Complex
BioGRID:199521	BioGRID:208275	Smarce1	BioGRID	PubMed	Reconstituted Complex
BioGRID:199521	BioGRID:203525	Stat5a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:204008	Tcf7l1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199521	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nuclear Receptors, organism-specific biosystem (from WikiPathways)
Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
Nuclear signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...

General gene information

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Markers

Esr1 (e-PCR), detects polymorphism
- UniSTS:506887

NoName (e-PCR)
- UniSTS:236299

AU018232 (e-PCR)
- UniSTS:208488

Esr1 (e-PCR), detects polymorphism
- UniSTS:256888

PMC25853P1 (e-PCR)
- UniSTS:272290

RH124384 (e-PCR)
- UniSTS:161206

Esr1 (e-PCR), detects polymorphism
- UniSTS:143041

Esr1 (e-PCR), detects polymorphism
- UniSTS:257222

Esr1 (e-PCR), detects polymorphism
- UniSTS:257223

Esr1 (e-PCR), detects polymorphism
- UniSTS:275685

Homology

Homologs of the Esr1 gene: The Esr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	ISO Inferred from Sequence Orthology more info
beta-catenin binding	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
estrogen receptor activity	ISO Inferred from Sequence Orthology more info
estrogen response element binding	ISO Inferred from Sequence Orthology more info
estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	ISO Inferred from Sequence Orthology more info
hormone binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
lipid binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
steroid binding	ISO Inferred from Sequence Orthology more info
steroid hormone receptor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	IPI Inferred from Physical Interaction more info
type 1 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
antral ovarian follicle growth	IMP Inferred from Mutant Phenotype more info	PubMed
cell growth	NAS Non-traceable Author Statement more info	PubMed
cellular response to estrogen stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial cell proliferation involved in mammary gland duct elongation	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland branching involved in pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
negative regulation of mitosis	NAS Non-traceable Author Statement more info	PubMed
negative regulation of neuron death	ISO Inferred from Sequence Orthology more info
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
positive regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
prostate epithelial cord elongation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
uterus development	IGI Inferred from Genetic Interaction more info	PubMed
vagina development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
T-tubule	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial part	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
perikaryon	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info
terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estrogen receptor

Names: estrogen receptor; ER; estradiol receptor; nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007956.4 → NP_031982.1 estrogen receptor

Status: PROVISIONAL

Source sequence(s)

AC153573, AC156393, AC158617

Consensus CDS

CCDS56678.1

UniProtKB/TrEMBL

E7FJU2

UniProtKB/Swiss-Prot

P19785

Related

ENSMUSP00000070070, OTTMUSP00000022869, ENSMUST00000067086, OTTMUST00000049381

Conserved Domains (3) summary

cd06949
Location:314 – 551
Blast Score: 1013

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:184 – 252
Blast Score: 436

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 – 185
Blast Score: 346

Oest_recep; Oestrogen receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000076.6 Reference GRCm38.p1 C57BL/6J

Range

4612046..5003761

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000032.1 Alternate Mm_Celera

Range

4553702..4949051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01082870.1 (7207..14235)	None
genomic	AAHY01082871.1	None
genomic	AAHY01082872.1	None
genomic	AAHY01082873.1	None
genomic	AAHY01082874.1	None
genomic	AAHY01082875.1	None
genomic	AAHY01082876.1	None
genomic	AAHY01082877.1	None
genomic	AAHY01082878.1	None
genomic	AAHY01082879.1	None
genomic	AAHY01082880.1	None
genomic	AAHY01082881.1	None
genomic	AAHY01082882.1	None
genomic	AAHY01082883.1	None
genomic	AAHY01082884.1	None
genomic	AAHY01082885.1	None
genomic	AAHY01082886.1	None
genomic	AAHY01082887.1	None
genomic	AAHY01082888.1	None
genomic	AAHY01082889.1	None
genomic	AAHY01082890.1	None
genomic	AAHY01082891.1	None
genomic	AAHY01082892.1	None
genomic	AAHY01082893.1	None
genomic	AAHY01082894.1	None
genomic	AC153573.3 (29438..200011)	None
genomic	AC156393.12 (76537..164936)	None
genomic	AC158617.9 (79917..171628)	None
genomic	AC158639.8	None
genomic	AJ276597.1	CAB85618.1	C57BL/6J
genomic	CH466562.2	EDL03580.1	mixed
		EDL03581.1	mixed
		EDL03582.1	mixed
		EDL03583.1	mixed
genomic	M38652.1	None
mRNA	AB560752.1	BAJ65337.1	C57BL/6J
mRNA	AB560753.1	BAJ65338.1	C57BL/6J
mRNA	AB560754.1	BAJ65339.1	C57BL/6J
mRNA	AB560755.1	BAJ65340.1	C57BL/6J
mRNA	AB560756.1	BAJ65341.1	C57BL/6J
mRNA	AB560757.1	BAJ65342.1	C57BL/6J
mRNA	AB560758.1	BAJ65343.1	C57BL/6J
mRNA	AB560759.1	BAJ65344.1	C57BL/6J
mRNA	AB560760.1	BAJ65345.1	C57BL/6J
mRNA	AF128220.1	AAF22561.1	B10.S/J
mRNA	AF128221.1	AAF22562.1	SJL/J
mRNA	AJ272161.1	None	C57BL/6J
mRNA	AJ272162.1	None	C57BL/6J
mRNA	AJ272163.1	None	C57BL/6J
mRNA	AJ272164.1	None	C57BL/6J
mRNA	AJ272165.1	None	C57BL/6J
mRNA	AJ272166.1	None	C57BL/6J
mRNA	AK033270.1	None	C57BL/6J
mRNA	AK036627.1	BAC29510.1	C57BL/6J
mRNA	AK039911.1	None	C57BL/6J
mRNA	AK041525.1	BAC30973.1	C57BL/6J
mRNA	AK054182.1	None	C57BL/6J
mRNA	AK077236.1	None	C57BL/6J
mRNA	AK087638.1	None	C57BL/6J
mRNA	AK134392.1	None	C57BL/6J
mRNA	AK136228.1	BAE22884.1	C57BL/6J
mRNA	AK139745.1	BAE24122.1	C57BL/6J
mRNA	EU791538.1	ACF17956.1	Swiss Albino
mRNA	EU791540.1	ACF17958.1	Swiss Albino
mRNA	M38651.1	AAA37580.1
other-genetic	BC167246.1	AAI67246.1