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    ACTRT1 actin-related protein T1 [ Homo sapiens ]

    Gene ID: 139741, updated on 11-May-2012
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    Summary

    Official Symbol
    ACTRT1provided by HGNC
    Official Full Name
    actin-related protein T1provided by HGNC
    Primary source
    HGNC:24027
    Locus tag
    RP1-203C2.1
    See related
    Ensembl:ENSG00000123165; HPRD:06439; MIM:300487; Vega:OTTHUMG00000022359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP1; ARIP1; ARPT1; HSD27; KIAA0705; MGC26590
    Summary
    This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]
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    Genomic context

    Location :
    Xq25
    Sequence :
    Chromosome: X; NC_000023.10 (127184941..127186382, complement)
    See ACTRT1 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene patatin-like phospholipase domain containing 10 pseudogene Neighboring gene kinesin heavy chain member 2A pseudogene Neighboring gene zinc finger protein 674 pseudogene Neighboring gene BTG family, member 3 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    4. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. Heid H, et al. Exp Cell Res, 2002 Oct 1. PMID 12243744.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Describes the discovery of two actin-related proteins as major components in a cytoskeletal, nonmotile structure of bull spermatozoa, suggesting that certain members of this family of proteins may serve functions other than nucleation of actin filaments.
      Title: Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    actin-related protein T1
    Names
    actin-related protein T1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021358.1 RefSeqGene

      Range
      5001..6442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138289.3 → NP_612146.1  actin-related protein T1

      Status: REVIEWED

      Source sequence(s)
      BC014597, DB452140, DB510229
      Consensus CDS
      CCDS14611.1
      UniProtKB/Swiss-Prot
      Q8TDG2
      Related
      ENSP00000360165, OTTHUMP00000023981, ENST00000371124, OTTHUMT00000058192
      Conserved Domains (2) summary
      cd00012
      Location:11 – 374
      Blast Score: 1102
      ACTIN; Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one ...
      pfam00022
      Location:7 – 376
      Blast Score: 1099
      Actin; Actin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      127184941..127186382, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      116588275..116589716, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic CH471107.2 EAX11839.1
    genomic Z74696.1 CAI42428.1
    mRNA AF440739.1 AAM00432.1
    mRNA AY251532.1 AAP20055.1
    mRNA BC014597.1 AAH14597.1
    mRNA DB452140.1 None
    mRNA DB510229.1 None
    other-genetic EU832175.1 ACE87525.1
    other-genetic EU832268.1 ACE86838.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDG2.2 GenPept UniProtKB/Swiss-Prot:Q8TDG2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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