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ADGRG4 adhesion G protein-coupled receptor G4 [ Homo sapiens (human) ]

Gene ID: 139378, updated on 8-May-2016
Official Symbol
ADGRG4provided by HGNC
Official Full Name
adhesion G protein-coupled receptor G4provided by HGNC
Primary source
HGNC:HGNC:18992
See related
Ensembl:ENSG00000156920 HPRD:06578; Vega:OTTHUMG00000022508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR17; GPR112; RP1-299I16
Summary
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Orthologs
Location:
Xq26.3
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (136300963..136416907)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135383122..135499047)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 3 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene bombesin like receptor 3 Neighboring gene HIV-1 Tat specific factor 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp781E1948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adhesion G-protein coupled receptor G4
Names
G protein-coupled receptor 112
probable G-protein coupled receptor 112

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021219.1 RefSeqGene

    Range
    5001..120926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153834.3NP_722576.3  adhesion G-protein coupled receptor G4

    See identical proteins and their annotated locations for NP_722576.3

    Status: REVIEWED

    Source sequence(s)
    AY140954, AY882585
    Consensus CDS
    CCDS35409.1
    UniProtKB/Swiss-Prot
    Q8IZF6
    Related
    ENSP00000377699, OTTHUMP00000183579, ENST00000394143, OTTHUMT00000286639
    Conserved Domains (3) summary
    pfam01825
    Location:26842728
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:27432982
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    136300963..136416907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531268.1XP_011529570.1  

    See identical proteins and their annotated locations for XP_011529570.1

    UniProtKB/Swiss-Prot
    Q8IZF6
    Related
    ENSP00000359686, ENST00000370652
    Conserved Domains (3) summary
    pfam01825
    Location:26842728
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:27432982
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. XM_011531269.1XP_011529571.1  

    See identical proteins and their annotated locations for XP_011529571.1

    UniProtKB/Swiss-Prot
    Q8IZF6
    Related
    ENSP00000377697, OTTHUMP00000183578, ENST00000394141, OTTHUMT00000286638
    Conserved Domains (3) summary
    pfam01825
    Location:26842728
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:27432982
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. XM_011531270.1XP_011529572.1  

    Conserved Domains (3) summary
    pfam01825
    Location:26392683
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:26982937
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  4. XM_011531272.1XP_011529574.1  

    Conserved Domains (2) summary
    pfam01825
    Location:26842728
    GPS; Latrophilin/CL-1-like GPS domain
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  5. XM_011531273.1XP_011529575.1  

    Conserved Domains (1) summary
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  6. XM_011531274.1XP_011529576.1  

    Conserved Domains (1) summary
    cl22861
    Location:28210
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  7. XM_011531271.1XP_011529573.1  

    Conserved Domains (3) summary
    pfam01825
    Location:26212665
    GPS; Latrophilin/CL-1-like GPS domain
    cl21587
    Location:26802919
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl22861
    Location:2147
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    135294203..135410110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)