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BEND2 BEN domain containing 2 [ Homo sapiens (human) ]

Gene ID: 139105, updated on 8-May-2016
Official Symbol
BEND2provided by HGNC
Official Full Name
BEN domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28509
See related
Ensembl:ENSG00000177324 HPRD:06646; Vega:OTTHUMG00000021211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf20
Summary
This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Orthologs
Location:
Xp22.13
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (18162931..18220904, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (18181051..18239024, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MDM4, p53 regulator pseudogene Neighboring gene long intergenic non-protein coding RNA 1456 Neighboring gene sex comb on midleg-like 2 (Drosophila) Neighboring gene thymosin beta 10 pseudogene 2 Neighboring gene cyclin dependent kinase like 5 Neighboring gene gap junction protein alpha 6 pseudogene

Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
BEN domain-containing protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021323.1 RefSeqGene

    Range
    5001..62974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184767.1NP_001171696.1  BEN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL096763, BC096745, BX952865
    Consensus CDS
    CCDS55375.1
    UniProtKB/Swiss-Prot
    Q8NDZ0
    Related
    ENSP00000369369, ENST00000380030
    Conserved Domains (2) summary
    smart01025
    Location:414489
    BEN; The BEN domain is found in diverse animal proteins
    pfam13900
    Location:84126
    GVQW; Putative binding domain
  2. NM_153346.4NP_699177.2  BEN domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_699177.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK128155, AL096763, BC037301, BX952865
    Consensus CDS
    CCDS14184.1
    UniProtKB/Swiss-Prot
    Q8NDZ0
    UniProtKB/TrEMBL
    B3KXX8
    Related
    ENSP00000369372, OTTHUMP00000022999, ENST00000380033, OTTHUMT00000055940
    Conserved Domains (2) summary
    smart01025
    Location:687763
    BEN; The BEN domain is found in diverse animal proteins
    pfam13900
    Location:84126
    GVQW; Putative binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    18162931..18220904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545447.1XP_011543749.1  

    Conserved Domains (2) summary
    smart01025
    Location:701777
    BEN; The BEN domain is found in diverse animal proteins
    pfam13900
    Location:84126
    GVQW; Putative binding domain
  2. XM_011545446.1XP_011543748.1  

    Conserved Domains (2) summary
    smart01025
    Location:722798
    BEN; The BEN domain is found in diverse animal proteins
    pfam13900
    Location:84126
    GVQW; Putative binding domain
  3. XM_011545448.1XP_011543750.1  

    Conserved Domains (2) summary
    smart01025
    Location:540615
    BEN; The BEN domain is found in diverse animal proteins
    pfam13900
    Location:84126
    GVQW; Putative binding domain

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    18211427..18269392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)