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    CREM cAMP responsive element modulator [ Homo sapiens ]

    Gene ID: 1390, updated on 19-May-2012
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    Summary

    Official Symbol
    CREMprovided by HGNC
    Official Full Name
    cAMP responsive element modulatorprovided by HGNC
    Primary source
    HGNC:2352
    Locus tag
    RP11-324I22.1
    See related
    Ensembl:ENSG00000095794; HPRD:00444; MIM:123812; Vega:OTTHUMG00000017953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICER; CREM-2; hCREM-2; MGC17881; MGC41893; MGC111110
    Summary
    This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    10p11.21
    Sequence :
    Chromosome: 10; NC_000010.10 (35415801..35501886)
    See CREM in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene cullin 2 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 4 Neighboring gene cyclin Y Neighboring gene gap junction protein, delta 4, 40.1kDa

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia. Crisafulli C, et al. Neurosci Lett, 2012 Feb 2. PMID 22198373.
    2. cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). Hedrich CM, et al. J Biol Chem, 2012 Feb 10. PMID 22184122.
    3. cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. Rauen T, et al. J Biol Chem, 2011 Dec 16. PMID 22025620.
    4. The CREM gene is involved in genetic predisposition to inflammatory bowel disease in the Tunisian population. Bouzid D, et al. Hum Immunol, 2011 Dec. PMID 22019623.
    5. Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity. Favre D, et al. Diabetes, 2011 Dec. PMID 21998402.

    See all (85) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. scriptive Statement The rsults of this study suggested the lack of influence of SNPs under investigation in the present study on the susceptibility to schizophrenia and on the response to antipsychotics.
      Title: Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
    2. cAMP-responsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
      Title: cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
    3. Common variants of the CREM gene are involved in the genetic component conferring general susceptibility to inflammatory bowel disease in the Tunisian population.
      Title: The CREM gene is involved in genetic predisposition to inflammatory bowel disease in the Tunisian population.
    4. Data provide direct evidence that CREMalpha mediates silencing of the IL2 gene in SLE T cells though histone deacetylation and CpG-DNA methylation.
      Title: cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.
    5. cAMP-responsive element modulator (CREM)alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.
      Title: cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.
    6. Induction of ICER links oxidative stress to beta cell failure caused by oxidised LDL, and it can be effectively abrogated by antioxidant treatment.
      Title: Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.
    7. Impaired expression of ICER contributes to elevation in CREB target genes and, therefore, to the development of insulin resistance in obesity.
      Title: Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity.
    8. Phosphorylation of ICER on a discrete residue targeted ICER to be monoubiquitinated.
      Title: Evidence that phosphorylation by the mitotic kinase Cdk1 promotes ICER monoubiquitination and nuclear delocalization.
    9. AP-1-dependent up-regulation of the P2 promoter, SLE T cells fail to further increase their basal CREM levels upon T cell activation due to a decreased content of the AP-1 family member c-Fos
      Title: A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.
    10. ICER mediates chemotherapy anticancer activity through DUSP1-p38 pathway activation and drives the cell program from survival to apoptosis
      Title: ICER evokes Dusp1-p38 pathway enhancing chemotherapy sensitivity in myeloid leukemia.
    Submit: New GeneRIF Correction See all (47)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
    tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_853549.1 NP_004350.1 CDC34    HPRD  PubMed  
    NP_853549.1 Active transcription factor CREB CREB1    HPRD  PubMed  
    NP_853549.1 ACT FHL5    HPRD  PubMed  
    NP_853549.1 NP_038462.1 KCNIP3    HPRD  PubMed  
    NP_853549.1 SPI1 SPI1    HPRD  PubMed  
    NP_853549.1 TBP associated factor 4 TAF4    HPRD  PubMed  
    NP_853549.1 TATA box binding protein TBP    HPRD  PubMed  
    Q03060 P18846 ATF1    HPRD  PubMed  
    Q03060 Q13557 CAMK2D    HPRD  PubMed  
    Q03060 Q13555 CAMK2G    HPRD  PubMed  
    Q03060 P49427 CDC34    HPRD  PubMed  
    Q03060 P06493 CDK1    HPRD  PubMed  
    Q03060 P16220 CREB1    HPRD  PubMed  
    Q03060 cAMP responsive element binding protein 3 like 1 CREB3L1    HPRD  PubMed  
    Q03060 Q92793 CREBBP    HPRD  PubMed  
    Q03060 Q03060 CREM    HPRD  PubMed  
    Q03060 P48729 CSNK1A1    HPRD  PubMed  
    Q03060 P68400 CSNK2A1    HPRD  PubMed  
    Q03060 P19784 CSNK2A2    HPRD  PubMed  
    Q03060 Q5TD97 FHL5    HPRD  PubMed  
    Q03060 P49840 GSK3A    HPRD  PubMed  
    Q03060 P49841 GSK3B    HPRD  PubMed  
    Q03060 Q9Y2W7 KCNIP3    HPRD  PubMed  
    Q03060 P17612 PRKACA    HPRD  PubMed  
    Q03060 P17252 PRKCA    HPRD  PubMed  
    Q03060 P17947 SPI1    HPRD  PubMed  
    Q03060 O00268 TAF4    HPRD  PubMed  
    Q03060 P20226 TBP    HPRD  PubMed  
    BioGRID:107780 BioGRID:107385 CD34    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:127142 CREB3L4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107780 BioGRID:114846 FHL5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107780 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107780 BioGRID:119042 KCNIP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107780 BioGRID:112566 SPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:112737 TAF4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cAMP response element binding protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    cAMP-responsive element modulator
    Names
    cAMP-responsive element modulator
    CREM 2beta-a protein
    CREM 2alpha-b protein
    cAMP response element modulator
    inducible cAMP early repressor ICER
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029065.1 RefSeqGene

      Range
      4969..91086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001881.3 → NP_001872.3  cAMP-responsive element modulator isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (b) with a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      BC017117, BC066342, DA756152
      Consensus CDS
      CCDS7184.1
      UniProtKB/TrEMBL
      Q96AG7
      Related
      ENSP00000363858, OTTHUMP00000019443, ENST00000374726, OTTHUMT00000047551
      Conserved Domains (1) summary
      pfam02173
      Location:53 – 89
      Blast Score: 156
      pKID; pKID domain

    2. NM_181571.2 → NP_853549.1  cAMP-responsive element modulator isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). This isoform represents an activator tau2 isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, BI561543
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000265372, OTTHUMP00000216727, ENST00000345491, OTTHUMT00000357708
      Conserved Domains (2) summary
      pfam02173
      Location:69 – 105
      Blast Score: 165
      pKID; pKID domain
      cl02576
      Location:239 – 295
      Blast Score: 122
      bZIP_1; bZIP transcription factor

    3. NM_182717.1 → NP_874386.1  cAMP-responsive element modulator isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (d) with distinct N- and C-termini, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS7187.1
      UniProtKB/TrEMBL
      Q14501
      Related
      ENSP00000420681, OTTHUMP00000019446, ENST00000473940, OTTHUMT00000047554
      Conserved Domains (1) summary
      cl02576
      Location:60 – 116
      Blast Score: 106
      bZIP_1; bZIP transcription factor

    4. NM_182718.1 → NP_874387.1  cAMP-responsive element modulator isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (e) with a distinct N-terminus, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53519.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417460, OTTHUMP00000216745, ENST00000488328, OTTHUMT00000357739
      Conserved Domains (1) summary
      cl02576
      Location:48 – 104
      Blast Score: 107
      bZIP_1; bZIP transcription factor

    5. NM_182719.1 → NP_874388.1  cAMP-responsive element modulator isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (f) with a distinct N-terminus, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS53517.1
      UniProtKB/TrEMBL
      Q14501
      Related
      ENSP00000417807, OTTHUMP00000216835, ENST00000487763, OTTHUMT00000357909
      Conserved Domains (1) summary
      cl02576
      Location:60 – 116
      Blast Score: 106
      bZIP_1; bZIP transcription factor

    6. NM_182720.1 → NP_874389.1  cAMP-responsive element modulator isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (g) with distinct N- and C-termini, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53518.1
      UniProtKB/TrEMBL
      A8K3J7
      Related
      ENSP00000349387, OTTHUMP00000216746, ENST00000356917, OTTHUMT00000357740
      Conserved Domains (1) summary
      cl02576
      Location:48 – 104
      Blast Score: 106
      bZIP_1; bZIP transcription factor

    7. NM_182721.1 → NP_874390.1  cAMP-responsive element modulator isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (h) with distinct N- and C-termini, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS7188.1
      Related
      ENSP00000417562, OTTHUMP00000216750, ENST00000474931, OTTHUMT00000047562
      Conserved Domains (1) summary
      cl02576
      Location:52 – 108
      Blast Score: 97
      bZIP_1; bZIP transcription factor

    8. NM_182722.1 → NP_874391.1  cAMP-responsive element modulator isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (i) with distinct N- and C-termini, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814, CN367927
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000344365, OTTHUMP00000216747, ENST00000344351, OTTHUMT00000357741
      Conserved Domains (1) summary
      cl02576
      Location:35 – 91
      Blast Score: 94
      bZIP_1; bZIP transcription factor

    9. NM_182723.1 → NP_874392.1  cAMP-responsive element modulator isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (j) with distinct N- and C-termini, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814
      Consensus CDS
      CCDS53521.1
      Related
      ENSP00000419075, OTTHUMP00000216748, ENST00000488741, OTTHUMT00000357742
      Conserved Domains (1) summary
      cl02576
      Location:42 – 98
      Blast Score: 99
      bZIP_1; bZIP transcription factor

    10. NM_182724.1 → NP_874393.1  cAMP-responsive element modulator isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (k) with a distinct N-terminus, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS53520.1
      UniProtKB/TrEMBL
      E9PAR4
      Related
      ENSP00000417327, OTTHUMP00000216749, ENST00000490511, OTTHUMT00000357743
      Conserved Domains (1) summary
      cl02576
      Location:52 – 108
      Blast Score: 98
      bZIP_1; bZIP transcription factor

    11. NM_182725.1 → NP_874394.1  cAMP-responsive element modulator isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (l) with a distinct N-terminus, compared to isoform a. This isoform represents the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814, CN367927
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Conserved Domains (1) summary
      cl02576
      Location:35 – 91
      Blast Score: 96
      bZIP_1; bZIP transcription factor

    12. NM_182769.2 → NP_877570.1  cAMP-responsive element modulator isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (m) with a distinct N-terminus, compared to isoform a. This isoform represents an activator isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      Consensus CDS
      CCDS7186.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000341875, OTTHUMP00000216785, ENST00000342105, OTTHUMT00000357799
      Conserved Domains (2) summary
      pfam02173
      Location:14 – 50
      Blast Score: 165
      pKID; pKID domain
      cl02576
      Location:184 – 240
      Blast Score: 127
      bZIP_1; bZIP transcription factor

    13. NM_182770.2 → NP_877571.1  cAMP-responsive element modulator isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (n) with a distinct N-terminus, compared to isoform a. This isoform represents a repressor isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419684, OTTHUMP00000216839, ENST00000463960, OTTHUMT00000357923
      Conserved Domains (2) summary
      pfam02173
      Location:14 – 50
      Blast Score: 157
      pKID; pKID domain
      cl02576
      Location:121 – 177
      Blast Score: 110
      bZIP_1; bZIP transcription factor

    14. NM_182771.1 → NP_877572.1  cAMP-responsive element modulator isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (o) with a distinct N-terminus, compared to isoform a. This isoform represents an activator isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      Consensus CDS
      CCDS7185.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000354593, OTTHUMP00000019448, ENST00000361599, OTTHUMT00000047558
      Conserved Domains (2) summary
      pfam02173
      Location:39 – 75
      Blast Score: 165
      pKID; pKID domain
      cl02576
      Location:209 – 265
      Blast Score: 126
      bZIP_1; bZIP transcription factor

    15. NM_182772.1 → NP_877573.1  cAMP-responsive element modulator isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (p) with a distinct N-terminus, compared to isoform a. This isoform represents a repressor isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417165, OTTHUMP00000216838, ENST00000484283, OTTHUMT00000357922
      Conserved Domains (2) summary
      pfam02173
      Location:39 – 75
      Blast Score: 158
      pKID; pKID domain
      cl02576
      Location:146 – 202
      Blast Score: 111
      bZIP_1; bZIP transcription factor

    16. NM_182850.2 → NP_878270.1  cAMP-responsive element modulator isoform q

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (q) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, BC041810, CN367927, DA756152
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Related
      ENSP00000419018, OTTHUMP00000216791, ENST00000474362, OTTHUMT00000357810
      Conserved Domains (1) summary
      cl02576
      Location:35 – 91
      Blast Score: 96
      bZIP_1; bZIP transcription factor

    17. NM_182853.2 → NP_878273.1  cAMP-responsive element modulator isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (r) with a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL117336, BC041810, CN367927, DA756152
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000420437, OTTHUMP00000216792, ENST00000460270, OTTHUMT00000357811
      Conserved Domains (1) summary
      cl02576
      Location:35 – 91
      Blast Score: 94
      bZIP_1; bZIP transcription factor

    18. NM_183011.1 → NP_898829.1  cAMP-responsive element modulator isoform u

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (u) with a distinct C-terminus, compared to isoform a. This isoform represents the tau2 activator isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS7181.1
      UniProtKB/TrEMBL
      E9PHM1
      UniProtKB/TrEMBL
      Q14501
      Related
      ENSP00000337138, OTTHUMP00000246777, ENST00000337656, OTTHUMT00000414969
      Conserved Domains (2) summary
      pfam02173
      Location:69 – 105
      Blast Score: 167
      pKID; pKID domain
      cl02576
      Location:239 – 295
      Blast Score: 124
      bZIP_1; bZIP transcription factor

    19. NM_183012.1 → NP_898830.1  cAMP-responsive element modulator isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (t) with a distinct C-terminus, compared to isoform a. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS31181.1
      UniProtKB/TrEMBL
      A8MPQ2
      UniProtKB/TrEMBL
      Q14501
      Related
      ENSP00000363866, OTTHUMP00000246778, ENST00000374734, OTTHUMT00000414970
      Conserved Domains (2) summary
      pfam02173
      Location:69 – 105
      Blast Score: 162
      pKID; pKID domain
      cl02576
      Location:176 – 232
      Blast Score: 109
      bZIP_1; bZIP transcription factor

    20. NM_183013.2 → NP_898831.1  cAMP-responsive element modulator isoform s

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (s) with a distinct C-terminus, compared to isoform a. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, DA756152
      Consensus CDS
      CCDS7182.1
      UniProtKB/TrEMBL
      Q14501
      UniProtKB/TrEMBL
      Q5W1B0
      Related
      ENSP00000346804, OTTHUMP00000019444, ENST00000354759, OTTHUMT00000047552
      Conserved Domains (2) summary
      pfam02173
      Location:69 – 105
      Blast Score: 162
      pKID; pKID domain
      cl02576
      Location:188 – 244
      Blast Score: 108
      bZIP_1; bZIP transcription factor

    21. NM_183060.2 → NP_898883.1  cAMP-responsive element modulator isoform v

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, AV707433, BC041810, BI561543
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      Q5W1A7
      Related
      ENSP00000363860, ENST00000374728
      Conserved Domains (2) summary
      pfam02173
      Location:53 – 89
      Blast Score: 159
      pKID; pKID domain
      cl02576
      Location:160 – 216
      Blast Score: 113
      bZIP_1; bZIP transcription factor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p5 Primary Assembly

      Range
      35415801..35501886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      35134266..35220214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF212158.1 AAF68266.2
    genomic AF213899.1 AAF68266.2
    genomic AF217318.1 AAF66158.2
      AAF68682.1
    genomic AL117336.22 CAH72495.1
      CAH72496.1
      CAH72497.1
      CAH72498.1
      CAH72499.1
      CAH72500.1
    genomic AL157783.15 CAI12137.1
      CAI12138.1
      CAI12139.1
      CAI12140.1
      CAI12141.1
      CAI12142.1
      CAI12143.1
      CAI12145.1
      CAI12146.1
      CAI12147.1
    genomic CH471072.2 EAW85916.1
      EAW85917.1
      EAW85918.1
      EAW85919.1
      EAW85920.1
    mRNA AB209533.1 BAD92770.1
    mRNA AF069065.1 AAC19383.1
    mRNA AF417233.1 AAN32655.1
    mRNA AF417234.1 AAN32656.1
    mRNA AK289379.1 BAF82068.1
    mRNA AK290612.1 BAF83301.1
    mRNA AK291566.1 BAF84255.1
    mRNA AK301906.1 BAG63333.1
    mRNA AU140010.1 None
    mRNA AV707433.1 None
    mRNA AY292864.1 AAP44115.1
    mRNA BC017117.1 AAH17117.1
    mRNA BC041810.1 None
    mRNA BC066342.1 AAH66342.1
    mRNA BC090051.1 AAH90051.1
    mRNA BE439480.1 None
    mRNA BG573680.1 None
    mRNA BG719264.1 None
    mRNA BI561543.1 None
    mRNA BP370901.1 None
    mRNA BX379412.2 None
    mRNA CD686814.1 None
    mRNA CN367927.1 None
    mRNA D14825.1 BAA03562.1
    mRNA D14826.1 BAA03564.1
      BAA03565.1
      BAA03566.1
      BAA03567.1
    mRNA D14826.1 BAA03564.1
      BAA03565.1
      BAA03566.1
      BAA03567.1
    mRNA DA756152.1 None
    mRNA S68134.1 AAC60617.2
    mRNA S68271.1 AAC60616.2
    mRNA U44836.1 AAB03751.1
    mRNA Y08959.1 None
    mRNA Z15159.1 CAA78858.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03060.5 GenPept UniProtKB/Swiss-Prot:Q03060
    Q14501 GenPept UniProtKB/TrEMBL:Q14501
    Q59FC7 GenPept UniProtKB/TrEMBL:Q59FC7
    Q5T9H8 GenPept UniProtKB/TrEMBL:Q5T9H8
    Q5T9I5 GenPept UniProtKB/TrEMBL:Q5T9I5
    Q5W1A7 GenPept UniProtKB/TrEMBL:Q5W1A7
    Q5W1B0 GenPept UniProtKB/TrEMBL:Q5W1B0
    Q96AG7 GenPept UniProtKB/TrEMBL:Q96AG7
    Help top of page

    Additional Links

    Gene LinkOut

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