CREM cAMP responsive element modulator [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CREMprovided by HGNC
Official Full Name: cAMP responsive element modulatorprovided by HGNC
Primary source: HGNC:2352
Locus tag: RP11-324I22.1
See related: Ensembl:ENSG00000095794; HPRD:00444; MIM:123812; Vega:OTTHUMG00000017953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ICER; CREM-2; hCREM-2
Summary: This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 10p11.21

Sequence :: Chromosome: 10; NC_000010.10 (35415769..35501886)

See CREM in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggested that the single nucleotide polymorphisms of CREM do not influence diagnosis and treatment response in patients with major depressive disorder and bipolar disorder.
Title: Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder.
Increased CREMalpha binding to the Notch-1 promoter resulted in significantly reduced Notch-1 promoter activity and gene transcription.
Title: cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).
Data indicate that CpG-DNA methylation and mRNA expression of CREM, IL2, and IL17A of systemic lupus erythematosus (SLE) T cells reflect the effector memory CD4+ T-cell phenotype.
Title: cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
CREM expression is increased in thyroid cancer tissue and may play a role in the downregulation of sodium iodide symporter expression in thyroid cancer acting at the transcriptional level
Title: Cyclic AMP-response element modulator inhibits the promoter activity of the sodium iodide symporter gene in thyroid cancer cells.
Estrogen can modulate the expression of CREMalpha and lead to IL-2 suppression in human T lymphocytes, thus revealing a molecular link between hormones and the immune system in Systemic lupus erythematosus
Title: Estrogen upregulates cyclic AMP response element modulator α expression and downregulates interleukin-2 production by human T lymphocytes.
CREMalpha suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.
Title: CREMα suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells.
scriptive Statement The rsults of this study suggested the lack of influence of SNPs under investigation in the present study on the susceptibility to schizophrenia and on the response to antipsychotics.
Title: Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
cAMP-responsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
Title: cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
Common variants of the CREM gene are involved in the genetic component conferring general susceptibility to inflammatory bowel disease in the Tunisian population.
Title: The CREM gene is involved in genetic predisposition to inflammatory bowel disease in the Tunisian population.
Data provide direct evidence that CREMalpha mediates silencing of the IL2 gene in SLE T cells though histone deacetylation and CpG-DNA methylation.
Title: cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.

Submit: New GeneRIF Correction See all (53)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter	PubMed
	tat	Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_853549.1	NP_004350.1	CDC34	HPRD	PubMed
NP_853549.1	Active transcription factor CREB	CREB1	HPRD	PubMed
NP_853549.1	ACT	FHL5	HPRD	PubMed
NP_853549.1	NP_038462.1	KCNIP3	HPRD	PubMed
NP_853549.1	SPI1	SPI1	HPRD	PubMed
NP_853549.1	TBP associated factor 4	TAF4	HPRD	PubMed
NP_853549.1	TATA box binding protein	TBP	HPRD	PubMed
Q03060	P18846	ATF1	HPRD	PubMed
Q03060	Q13557	CAMK2D	HPRD	PubMed
Q03060	Q13555	CAMK2G	HPRD	PubMed
Q03060	P49427	CDC34	HPRD	PubMed
Q03060	P06493	CDK1	HPRD	PubMed
Q03060	P16220	CREB1	HPRD	PubMed
Q03060	cAMP responsive element binding protein 3 like 1	CREB3L1	HPRD	PubMed
Q03060	Q92793	CREBBP	HPRD	PubMed
Q03060	Q03060	CREM	HPRD	PubMed
Q03060	P48729	CSNK1A1	HPRD	PubMed
Q03060	P68400	CSNK2A1	HPRD	PubMed
Q03060	P19784	CSNK2A2	HPRD	PubMed
Q03060	Q5TD97	FHL5	HPRD	PubMed
Q03060	P49840	GSK3A	HPRD	PubMed
Q03060	P49841	GSK3B	HPRD	PubMed
Q03060	Q9Y2W7	KCNIP3	HPRD	PubMed
Q03060	P17612	PRKACA	HPRD	PubMed
Q03060	P17252	PRKCA	HPRD	PubMed
Q03060	P17947	SPI1	HPRD	PubMed
Q03060	O00268	TAF4	HPRD	PubMed
Q03060	P20226	TBP	HPRD	PubMed
BioGRID:107780	BioGRID:112217	ATXN1	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:115315	CASP8AP2	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:107385	CD34	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:127142	CREB3L4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107780	BioGRID:108329	EMP3	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:114846	FHL5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107780	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107780	BioGRID:1777030	HHV8GK18_gp81	BioGRID	PubMed	Far Western
BioGRID:107780	BioGRID:119042	KCNIP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107780	BioGRID:111581	MAPK3	BioGRID	PubMed	Biochemical Activity
BioGRID:107780	BioGRID:115673	PIAS3	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:112555	SP100	BioGRID	PubMed	Two-hybrid
BioGRID:107780	BioGRID:112566	SPI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107780	BioGRID:112737	TAF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107780	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107780	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107780	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...

General gene information

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Markers

RH79198 (e-PCR)
- UniSTS:59165

CREM (e-PCR)
- UniSTS:480037

CREM_2014 (e-PCR)
- UniSTS:280622

A005C47 (e-PCR)
- UniSTS:47448

D15S1477 (e-PCR)
- UniSTS:474482

RH46931 (e-PCR)
- UniSTS:6270

RH80748 (e-PCR)
- UniSTS:88709

STS-N30098 (e-PCR)
- UniSTS:74638

G07255 (e-PCR)
- UniSTS:46257

GDB:335751 (e-PCR)
- UniSTS:156601

Homology

Homologs of the CREM gene: The CREM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	NAS Non-traceable Author Statement more info	PubMed
cAMP response element binding protein binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
glycosphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
spermatogenesis	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	NAS Non-traceable Author Statement more info
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cAMP-responsive element modulator

Names: cAMP-responsive element modulator; CREM 2beta-a protein; CREM 2alpha-b protein; cAMP response element modulator; inducible cAMP early repressor ICER

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029065.1 RefSeqGene

Range

4969..91086

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267562.1 → NP_001254491.1 cAMP-responsive element modulator isoform 23

Status: REVIEWED

Description

Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL117336, AY292864, BC041810, BG573680, BI459432, DA756152

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:118 – 174
Blast Score: 135

bZIP_1; bZIP transcription factor
NM_001267563.1 → NP_001254492.1 cAMP-responsive element modulator isoform 24

Status: REVIEWED

Description

Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AL117336, AL157783, BC041810, CB996061, DA756152

Conserved Domains (1) summary

pfam00170
Location:55 – 111
Blast Score: 111

bZIP_1; bZIP transcription factor
NM_001267564.1 → NP_001254493.1 cAMP-responsive element modulator isoform 25

Status: REVIEWED

Description

Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.

Source sequence(s)

AL117336, AY292864, BC041810, BU193626, CD358637

Consensus CDS

CCDS58074.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (2) summary

pfam02173
Location:39 – 75
Blast Score: 165

pKID; pKID domain

pfam00170
Location:221 – 277
Blast Score: 125

bZIP_1; bZIP transcription factor
NM_001267565.1 → NP_001254494.1 cAMP-responsive element modulator isoform 26

Status: REVIEWED

Description

Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.

Source sequence(s)

BU193626, BU570307, CK300763

Conserved Domains (2) summary

pfam02173
Location:66 – 83
Blast Score: 74

pKID; pKID domain

pfam13900
Location:29 – 67
Blast Score: 188

GVQW; Putative binding domain
NM_001267566.1 → NP_001254495.1 cAMP-responsive element modulator isoform 27

Status: REVIEWED

Description

Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.

Source sequence(s)

BP370901, BU570307, CK300763

Conserved Domains (1) summary

pfam02173
Location:14 – 50
Blast Score: 152

pKID; pKID domain
NM_001267567.1 → NP_001254496.1 cAMP-responsive element modulator isoform 28

Status: REVIEWED

Description

Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL117336, BC041810, BG720999, BP370901

Consensus CDS

CCDS58075.1

UniProtKB/TrEMBL

C9J785

Conserved Domains (1) summary

pfam00170
Location:77 – 133
Blast Score: 122

bZIP_1; bZIP transcription factor
NM_001267568.1 → NP_001254497.1 cAMP-responsive element modulator isoform 29

Status: REVIEWED

Description

Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AL117336, AW439476, CD639591, CD640977, D14826
NM_001267569.1 → NP_001254498.1 cAMP-responsive element modulator isoform 30

Status: REVIEWED

Description

Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.

Source sequence(s)

AL117336, AW439476, CD640977, D14826
NM_001267570.1 → NP_001254499.1 cAMP-responsive element modulator isoform 31

Status: REVIEWED

Description

Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK289379, AL117336, BC041810, CD640465

Consensus CDS

CCDS58076.1

UniProtKB/TrEMBL

C9JZ10

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:64 – 120
Blast Score: 98

bZIP_1; bZIP transcription factor
NM_001881.3 → NP_001872.3 cAMP-responsive element modulator isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC017117, BC066342, DA756152

Consensus CDS

CCDS7184.1

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000363858, OTTHUMP00000019443, ENST00000374726, OTTHUMT00000047551

Conserved Domains (1) summary

pfam02173
Location:53 – 89
Blast Score: 156

pKID; pKID domain
NM_181571.2 → NP_853549.1 cAMP-responsive element modulator isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.

Source sequence(s)

AL117336, AL157783, BC041810, BI561543

Consensus CDS

CCDS7180.1

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000265372, OTTHUMP00000216727, ENST00000345491, OTTHUMT00000357708

Conserved Domains (2) summary

pfam02173
Location:69 – 105
Blast Score: 165

pKID; pKID domain

pfam00170
Location:239 – 295
Blast Score: 122

bZIP_1; bZIP transcription factor
NM_182717.1 → NP_874386.1 cAMP-responsive element modulator isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AL117336, AL157783, BC041810, D14825, D14826

Consensus CDS

CCDS7187.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:60 – 116
Blast Score: 106

bZIP_1; bZIP transcription factor
NM_182718.1 → NP_874387.1 cAMP-responsive element modulator isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AL117336, BC041810, CN367927, D14826

Consensus CDS

CCDS53519.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:48 – 104
Blast Score: 107

bZIP_1; bZIP transcription factor
NM_182719.1 → NP_874388.1 cAMP-responsive element modulator isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AL117336, AL157783, BC041810, D14825, D14826

Consensus CDS

CCDS53517.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:60 – 116
Blast Score: 106

bZIP_1; bZIP transcription factor
NM_182720.1 → NP_874389.1 cAMP-responsive element modulator isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AL117336, BC041810, CN367927, D14826

Consensus CDS

CCDS53518.1

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000349387, OTTHUMP00000216746, ENST00000356917, OTTHUMT00000357740

Conserved Domains (1) summary

pfam00170
Location:48 – 104
Blast Score: 106

bZIP_1; bZIP transcription factor
NM_182721.1 → NP_874390.1 cAMP-responsive element modulator isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AK289379, AL117336, BC041810

Consensus CDS

CCDS7188.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:52 – 108
Blast Score: 97

bZIP_1; bZIP transcription factor
NM_182723.1 → NP_874392.1 cAMP-responsive element modulator isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AL117336, BC041810, CD686814

Consensus CDS

CCDS53521.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:42 – 98
Blast Score: 99

bZIP_1; bZIP transcription factor
NM_182724.1 → NP_874393.1 cAMP-responsive element modulator isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.

Source sequence(s)

AK289379, AL117336, BC041810

Consensus CDS

CCDS53520.1

UniProtKB/TrEMBL

E9PAR4

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (1) summary

pfam00170
Location:52 – 108
Blast Score: 98

bZIP_1; bZIP transcription factor
NM_182769.2 → NP_877570.1 cAMP-responsive element modulator isoform 13

Status: REVIEWED

Description

Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.

Source sequence(s)

AL117336, AY292864, BC041810, BG719264, BP370901

Consensus CDS

CCDS7186.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (2) summary

pfam02173
Location:14 – 50
Blast Score: 165

pKID; pKID domain

pfam00170
Location:184 – 240
Blast Score: 127

bZIP_1; bZIP transcription factor
NM_182770.2 → NP_877571.1 cAMP-responsive element modulator isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.

Source sequence(s)

AL117336, AY292864, BC041810, BG719264, BP370901

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (2) summary

pfam02173
Location:14 – 50
Blast Score: 157

pKID; pKID domain

pfam00170
Location:121 – 177
Blast Score: 110

bZIP_1; bZIP transcription factor
NM_182771.1 → NP_877572.1 cAMP-responsive element modulator isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.

Source sequence(s)

AL117336, AY292864, BC041810, BG719264

Consensus CDS

CCDS7185.1

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000354593, OTTHUMP00000019448, ENST00000361599, OTTHUMT00000047558

Conserved Domains (2) summary

pfam02173
Location:39 – 75
Blast Score: 165

pKID; pKID domain

pfam00170
Location:209 – 265
Blast Score: 126

bZIP_1; bZIP transcription factor
NM_182772.1 → NP_877573.1 cAMP-responsive element modulator isoform 16

Status: REVIEWED

Description

Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.

Source sequence(s)

AL117336, AY292864, BC041810, BG719264

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (2) summary

pfam02173
Location:39 – 75
Blast Score: 158

pKID; pKID domain

pfam00170
Location:146 – 202
Blast Score: 111

bZIP_1; bZIP transcription factor
NM_183011.1 → NP_898829.1 cAMP-responsive element modulator isoform 21

Status: REVIEWED

Description

Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.

Source sequence(s)

AL117336, AL157783, BC041810, D14825

Consensus CDS

CCDS7181.1

UniProtKB/TrEMBL

E9PHM1

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000333055, ENST00000333809

Conserved Domains (2) summary

pfam02173
Location:69 – 105
Blast Score: 167

pKID; pKID domain

pfam00170
Location:239 – 295
Blast Score: 124

bZIP_1; bZIP transcription factor
NM_183012.1 → NP_898830.1 cAMP-responsive element modulator isoform 20

Status: REVIEWED

Description

Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.

Source sequence(s)

AL117336, AL157783, BC041810, D14825

Consensus CDS

CCDS31181.1

UniProtKB/TrEMBL

A8MPQ2

UniProtKB/Swiss-Prot

Q03060

Related

ENSP00000409220, ENST00000439705

Conserved Domains (2) summary

pfam02173
Location:69 – 105
Blast Score: 162

pKID; pKID domain

pfam00170
Location:176 – 232
Blast Score: 109

bZIP_1; bZIP transcription factor
NM_183013.2 → NP_898831.1 cAMP-responsive element modulator isoform 19

Status: REVIEWED

Description

Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.

Source sequence(s)

AL117336, AL157783, BC041810, D14825, DA756152

Consensus CDS

CCDS7182.1

UniProtKB/Swiss-Prot

Q03060

Conserved Domains (2) summary

pfam02173
Location:69 – 105
Blast Score: 162

pKID; pKID domain

pfam00170
Location:188 – 244
Blast Score: 108

bZIP_1; bZIP transcription factor
NM_183060.2 → NP_898883.1 cAMP-responsive element modulator isoform 22

Status: REVIEWED

Description

Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.

Source sequence(s)

AL117336, AL157783, AV707433, BC041810, BI561543

Consensus CDS

CCDS7183.1

UniProtKB/TrEMBL

Q5W1A7

Related

ENSP00000363860, ENST00000374728

Conserved Domains (2) summary

pfam02173
Location:53 – 89
Blast Score: 159

pKID; pKID domain

pfam00170
Location:160 – 216
Blast Score: 113

bZIP_1; bZIP transcription factor

RNA

NR_051971.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (9) has an alternate first exon in place of the first 6 exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.

Source sequence(s)

AK289379, AL117336, BC041810, CD686814
NR_051972.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (12) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.

Source sequence(s)

AL117336, BC041810, CD686814, DT220562
NR_051973.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (17) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.

Source sequence(s)

AA453346, AL117336, AL157783, BC041810, DA756152
NR_051974.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (18) has an alternate first exon in place of the first two exons and lacks two other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.

Source sequence(s)

AL117336, AL157783, BC041810, CN367927, DA756152
NR_051975.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (32) has an alternate first exon in place of the first two exons and lacks three other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.

Source sequence(s)

AL117336, AL157783, BC041810, DA756152, DR760671

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p10 Primary Assembly

Range

35415769..35501886

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

35134234..35220214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018921.1 Alternate CHM1_1.0

Range

35315717..35401783

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_182722.1: Suppressed sequence

Description

NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
NM_182725.1: Suppressed sequence

Description

NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
NM_182850.2: Suppressed sequence

Description

NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
NM_182853.2: Suppressed sequence

Description

NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01033344.1 (15066..66676)	None
genomic	ABBA01033345.1	None
genomic	AF212158.1	AAF68266.2
genomic	AF213899.1	AAF68266.2
genomic	AF217318.1	AAF66158.2
		AAF68682.1
genomic	AL117336.22 (2000..6104)	None
genomic	AL157783.15 (15630..97643)	None
genomic	AMYH01002235.1 (23513..83682)	None
genomic	AMYH01002236.1	None
genomic	CH471072.2	EAW85916.1
		EAW85917.1
		EAW85918.1
		EAW85919.1
		EAW85920.1
mRNA	AA453346.1	None
mRNA	AB209533.1	BAD92770.1
mRNA	AF069065.1	AAC19383.1
mRNA	AF417233.1	AAN32655.1
mRNA	AF417234.1	AAN32656.1
mRNA	AK289379.1	BAF82068.1
mRNA	AK290612.1	BAF83301.1
mRNA	AK291566.1	BAF84255.1
mRNA	AK301906.1	BAG63333.1
mRNA	AU140010.1	None
mRNA	AV707433.1	None
mRNA	AW439476.1	None
mRNA	AY292864.1	AAP44115.1
mRNA	BC017117.1	AAH17117.1
mRNA	BC041810.1	None
mRNA	BC066342.1	AAH66342.1
mRNA	BC090051.1	AAH90051.1
mRNA	BE439480.1	None
mRNA	BG573680.1	None
mRNA	BG719264.1	None
mRNA	BG720999.1	None
mRNA	BI459432.1	None
mRNA	BI561543.1	None
mRNA	BP370901.1	None
mRNA	BU193626.1	None
mRNA	BU570307.1	None
mRNA	BX379412.2	None
mRNA	CB996061.1	None
mRNA	CD358637.1	None
mRNA	CD639591.1	None
mRNA	CD640465.1	None
mRNA	CD640977.1	None
mRNA	CD686814.1	None
mRNA	CK300763.1	None
mRNA	CN367927.1	None
mRNA	D14825.1	BAA03562.1
mRNA	D14826.1	BAA03564.1
		BAA03565.1
		BAA03566.1
		BAA03567.1
mRNA	DA756152.1	None
mRNA	DR760671.1	None
mRNA	DT220562.1	None
mRNA	S68134.1	AAC60617.2
mRNA	S68271.1	AAC60616.2
mRNA	U44836.1	AAB03751.1
mRNA	Y08959.1	None
mRNA	Z15159.1	CAA78858.1