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CREM cAMP responsive element modulator [ Homo sapiens (human) ]

Gene ID: 1390, updated on 24-Aug-2014
Official Symbol
CREMprovided by HGNC
Official Full Name
cAMP responsive element modulatorprovided by HGNC
Primary source
HGNC:2352
Locus tag
RP11-324I22.1
See related
Ensembl:ENSG00000095794; HPRD:00444; MIM:123812; Vega:OTTHUMG00000017953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICER; CREM-2; hCREM-2
Summary
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
See CREM in Epigenomics, MapViewer
Location:
10p11.21
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (35126841..35212958)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415769..35501886)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 pseudogene 2 Neighboring gene cullin 2 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 4 Neighboring gene cyclin Y Neighboring gene gap junction protein, delta 4, 40.1kDa

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
    Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC17881, MGC41893, MGC111110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
cAMP response element binding protein binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cAMP-responsive element modulator
Names
cAMP-responsive element modulator
CREM 2beta-a protein
CREM 2alpha-b protein
cAMP response element modulator
inducible cAMP early repressor ICER

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029065.1 

    Range
    4969..91086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267562.1NP_001254491.1  cAMP-responsive element modulator isoform 23

    See proteins identical to NP_001254491.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG573680, BI459432, DA756152
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:122174
    Blast Score: 177
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. NM_001267563.1NP_001254492.1  cAMP-responsive element modulator isoform 24

    See proteins identical to NP_001254492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AL157783, BC041810, CB996061, DA756152
    Conserved Domains (1) summary
    cd12193
    Location:59111
    Blast Score: 143
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. NM_001267564.1NP_001254493.1  cAMP-responsive element modulator isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BU193626, CD358637
    Consensus CDS
    CCDS58074.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:3975
    Blast Score: 171
    pKID; pKID domain
    cd12193
    Location:225277
    Blast Score: 168
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  4. NM_001267565.1NP_001254494.1  cAMP-responsive element modulator isoform 26

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BU193626, BU570307, CK300763
    Conserved Domains (2) summary
    pfam02173
    Location:6683
    Blast Score: 78
    pKID; pKID domain
    pfam13900
    Location:3267
    Blast Score: 186
    GVQW; Putative binding domain
  5. NM_001267566.1NP_001254495.1  cAMP-responsive element modulator isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BP370901, BU570307, CK300763
    Conserved Domains (1) summary
    pfam02173
    Location:1450
    Blast Score: 161
    pKID; pKID domain
  6. NM_001267567.1NP_001254496.1  cAMP-responsive element modulator isoform 28

    See proteins identical to NP_001254496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL117336, BC041810, BG720999, BP370901
    Consensus CDS
    CCDS58075.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:81133
    Blast Score: 158
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  7. NM_001267568.1NP_001254497.1  cAMP-responsive element modulator isoform 29

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD639591, CD640977, D14826
  8. NM_001267569.1NP_001254498.1  cAMP-responsive element modulator isoform 30

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL117336, AW439476, CD640977, D14826
    Conserved Domains (1) summary
    cl02338
    Location:665
    Blast Score: 75
    DUF2303; Uncharacterized conserved protein (DUF2303)
  9. NM_001267570.1NP_001254499.1  cAMP-responsive element modulator isoform 31

    See proteins identical to NP_001254499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK289379, AL117336, BC041810, CD640465
    Consensus CDS
    CCDS58076.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:68120
    Blast Score: 129
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  10. NM_001881.3NP_001872.3  cAMP-responsive element modulator isoform 2

    See proteins identical to NP_001872.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC017117, BC066342, DA756152
    Consensus CDS
    CCDS7184.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363858, OTTHUMP00000019443, ENST00000374726, OTTHUMT00000047551
    Conserved Domains (1) summary
    pfam02173
    Location:5389
    Blast Score: 165
    pKID; pKID domain
  11. NM_181571.2NP_853549.1  cAMP-responsive element modulator isoform 1

    See proteins identical to NP_853549.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, BI561543
    Consensus CDS
    CCDS7180.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000265372, OTTHUMP00000216727, ENST00000345491, OTTHUMT00000357708
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 171
    pKID; pKID domain
    cd12193
    Location:243295
    Blast Score: 171
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  12. NM_182717.1NP_874386.1  cAMP-responsive element modulator isoform 4

    See proteins identical to NP_874386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS7187.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:64116
    Blast Score: 122
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  13. NM_182718.1NP_874387.1  cAMP-responsive element modulator isoform 5

    See proteins identical to NP_874387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53519.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:52104
    Blast Score: 135
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  14. NM_182719.1NP_874388.1  cAMP-responsive element modulator isoform 6

    See proteins identical to NP_874388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, D14826
    Consensus CDS
    CCDS53517.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:64116
    Blast Score: 134
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  15. NM_182720.1NP_874389.1  cAMP-responsive element modulator isoform 7

    See proteins identical to NP_874389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CN367927, D14826
    Consensus CDS
    CCDS53518.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000349387, OTTHUMP00000216746, ENST00000356917, OTTHUMT00000357740
    Conserved Domains (1) summary
    cd12193
    Location:52104
    Blast Score: 122
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  16. NM_182721.1NP_874390.1  cAMP-responsive element modulator isoform 8

    See proteins identical to NP_874390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS7188.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:56108
    Blast Score: 117
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  17. NM_182723.1NP_874392.1  cAMP-responsive element modulator isoform 10

    See proteins identical to NP_874392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AL117336, BC041810, CD686814
    Consensus CDS
    CCDS53521.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:4698
    Blast Score: 117
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  18. NM_182724.1NP_874393.1  cAMP-responsive element modulator isoform 11

    See proteins identical to NP_874393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
    Source sequence(s)
    AK289379, AL117336, BC041810
    Consensus CDS
    CCDS53520.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:56108
    Blast Score: 129
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  19. NM_182769.2NP_877570.1  cAMP-responsive element modulator isoform 13

    See proteins identical to NP_877570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    Consensus CDS
    CCDS7186.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:1450
    Blast Score: 171
    pKID; pKID domain
    cd12193
    Location:188240
    Blast Score: 172
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  20. NM_182770.2NP_877571.1  cAMP-responsive element modulator isoform 14

    See proteins identical to NP_877571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264, BP370901
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:1450
    Blast Score: 162
    pKID; pKID domain
    cd12193
    Location:125177
    Blast Score: 146
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  21. NM_182771.1NP_877572.1  cAMP-responsive element modulator isoform 15

    See proteins identical to NP_877572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    Consensus CDS
    CCDS7185.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000354593, OTTHUMP00000019448, ENST00000361599, OTTHUMT00000047558
    Conserved Domains (2) summary
    pfam02173
    Location:3975
    Blast Score: 171
    pKID; pKID domain
    cd12193
    Location:213265
    Blast Score: 170
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  22. NM_182772.1NP_877573.1  cAMP-responsive element modulator isoform 16

    See proteins identical to NP_877573.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
    Source sequence(s)
    AL117336, AY292864, BC041810, BG719264
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:3975
    Blast Score: 164
    pKID; pKID domain
    cd12193
    Location:150202
    Blast Score: 148
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  23. NM_183011.1NP_898829.1  cAMP-responsive element modulator isoform 21

    See proteins identical to NP_898829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825
    Consensus CDS
    CCDS7181.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 174
    pKID; pKID domain
    cd12193
    Location:243295
    Blast Score: 157
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  24. NM_183012.1NP_898830.1  cAMP-responsive element modulator isoform 20

    See proteins identical to NP_898830.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825
    Consensus CDS
    CCDS31181.1
    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 167
    pKID; pKID domain
    cd12193
    Location:180232
    Blast Score: 138
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  25. NM_183013.2NP_898831.1  cAMP-responsive element modulator isoform 19

    See proteins identical to NP_898831.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, BC041810, D14825, DA756152
    Consensus CDS
    CCDS7182.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000409220, ENST00000439705
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 168
    pKID; pKID domain
    cd12193
    Location:192244
    Blast Score: 137
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  26. NM_183060.2NP_898883.1  cAMP-responsive element modulator isoform 22

    See proteins identical to NP_898883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
    Source sequence(s)
    AL117336, AL157783, AV707433, BC041810, BI561543
    Consensus CDS
    CCDS7183.1
    UniProtKB/Swiss-Prot
    Q03060
    Related
    ENSP00000363860, ENST00000374728
    Conserved Domains (2) summary
    pfam02173
    Location:5389
    Blast Score: 165
    pKID; pKID domain
    cd12193
    Location:164216
    Blast Score: 153
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RNA

  1. NR_051971.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate first exon in place of the first 6 exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
    Source sequence(s)
    AK289379, AL117336, BC041810, CD686814
  2. NR_051972.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
    Source sequence(s)
    AL117336, BC041810, CD686814, DT220562
  3. NR_051973.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
    Source sequence(s)
    AA453346, AL117336, AL157783, BC041810, DA756152
  4. NR_051974.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) has an alternate first exon in place of the first two exons and lacks two other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
    Source sequence(s)
    AL117336, AL157783, BC041810, CN367927, DA756152
  5. NR_051975.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32) has an alternate first exon in place of the first two exons and lacks three other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
    Source sequence(s)
    AL117336, AL157783, BC041810, DA756152, DR760671

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    35126841..35212958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717384.1XP_006717447.1  

    See proteins identical to XP_006717447.1

    Conserved Domains (1) summary
    cd12193
    Location:122174
    Blast Score: 177
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. XM_006717387.1XP_006717450.1  

    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 173
    pKID; pKID domain
    cd12193
    Location:255307
    Blast Score: 156
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. XM_006717379.1XP_006717442.1  

    See proteins identical to XP_006717442.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 174
    pKID; pKID domain
    cd12193
    Location:243295
    Blast Score: 157
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  4. XM_006717378.1XP_006717441.1  

    See proteins identical to XP_006717441.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 171
    pKID; pKID domain
    cd12193
    Location:243295
    Blast Score: 171
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  5. XM_006717383.1XP_006717446.1  

    See proteins identical to XP_006717446.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 167
    pKID; pKID domain
    cd12193
    Location:180232
    Blast Score: 138
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  6. XM_006717382.1XP_006717445.1  

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (2) summary
    pfam02173
    Location:69105
    Blast Score: 164
    pKID; pKID domain
    cd12193
    Location:180232
    Blast Score: 150
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  7. XM_006717385.1XP_006717448.1  

    See proteins identical to XP_006717448.1

    UniProtKB/Swiss-Prot
    Q03060
    Conserved Domains (1) summary
    cd12193
    Location:81133
    Blast Score: 158
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  8. XM_006717380.1XP_006717443.1  

    See proteins identical to XP_006717443.1

    Conserved Domains (2) summary
    pfam02173
    Location:5389
    Blast Score: 172
    pKID; pKID domain
    cd12193
    Location:227279
    Blast Score: 174
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  9. XM_006717381.1XP_006717444.1  

    See proteins identical to XP_006717444.1

    Conserved Domains (2) summary
    pfam02173
    Location:5389
    Blast Score: 172
    pKID; pKID domain
    cd12193
    Location:227279
    Blast Score: 174
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  10. XM_006717386.1XP_006717449.1  

    See proteins identical to XP_006717449.1

    Conserved Domains (1) summary
    cd12193
    Location:68120
    Blast Score: 118
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    35134234..35220214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    35416939..35502837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182722.1: Suppressed sequence

    Description
    NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_182725.1: Suppressed sequence

    Description
    NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  3. NM_182850.2: Suppressed sequence

    Description
    NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  4. NM_182853.2: Suppressed sequence

    Description
    NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.