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    CREM cAMP responsive element modulator [ Homo sapiens (human) ]

    Gene ID: 1390, updated on 14-May-2013
    Official Symbol
    CREMprovided by HGNC
    Official Full Name
    cAMP responsive element modulatorprovided by HGNC
    Primary source
    HGNC:2352
    Locus tag
    RP11-324I22.1
    See related
    Ensembl:ENSG00000095794; HPRD:00444; MIM:123812; Vega:OTTHUMG00000017953
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICER; CREM-2; hCREM-2
    Summary
    This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
    Location :
    10p11.21
    Sequence :
    Chromosome: 10; NC_000010.10 (35415769..35501886)
    See CREM in Epigenomics, MapViewer

    Chromosome 10 - NC_000010.10Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 pseudogene 2 Neighboring gene cullin 2 Neighboring gene microRNA 3611 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 4 Neighboring gene cyclin Y Neighboring gene gap junction protein, delta 4, 40.1kDa

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Tat, p14 tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
    tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_853549.1 NP_004350.1 CDC34    HPRD  PubMed  
    NP_853549.1 Active transcription factor CREB CREB1    HPRD  PubMed  
    NP_853549.1 ACT FHL5    HPRD  PubMed  
    NP_853549.1 NP_038462.1 KCNIP3    HPRD  PubMed  
    NP_853549.1 SPI1 SPI1    HPRD  PubMed  
    NP_853549.1 TBP associated factor 4 TAF4    HPRD  PubMed  
    NP_853549.1 TATA box binding protein TBP    HPRD  PubMed  
    Q03060 P18846 ATF1    HPRD  PubMed  
    Q03060 Q13557 CAMK2D    HPRD  PubMed  
    Q03060 Q13555 CAMK2G    HPRD  PubMed  
    Q03060 P49427 CDC34    HPRD  PubMed  
    Q03060 P06493 CDK1    HPRD  PubMed  
    Q03060 P16220 CREB1    HPRD  PubMed  
    Q03060 cAMP responsive element binding protein 3 like 1 CREB3L1    HPRD  PubMed  
    Q03060 Q92793 CREBBP    HPRD  PubMed  
    Q03060 Q03060 CREM    HPRD  PubMed  
    Q03060 P48729 CSNK1A1    HPRD  PubMed  
    Q03060 P68400 CSNK2A1    HPRD  PubMed  
    Q03060 P19784 CSNK2A2    HPRD  PubMed  
    Q03060 Q5TD97 FHL5    HPRD  PubMed  
    Q03060 P49840 GSK3A    HPRD  PubMed  
    Q03060 P49841 GSK3B    HPRD  PubMed  
    Q03060 Q9Y2W7 KCNIP3    HPRD  PubMed  
    Q03060 P17612 PRKACA    HPRD  PubMed  
    Q03060 P17252 PRKCA    HPRD  PubMed  
    Q03060 P17947 SPI1    HPRD  PubMed  
    Q03060 O00268 TAF4    HPRD  PubMed  
    Q03060 P20226 TBP    HPRD  PubMed  
    BioGRID:107780 BioGRID:112217 ATXN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:115315 CASP8AP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:107385 CD34    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:127142 CREB3L4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107780 BioGRID:108329 EMP3    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:114846 FHL5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107780 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107780 BioGRID:1777030 HHV8GK18_gp81    BioGRID  PubMed Far Western 
    BioGRID:107780 BioGRID:119042 KCNIP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107780 BioGRID:115673 PIAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:112555 SP100    BioGRID  PubMed Two-hybrid 
    BioGRID:107780 BioGRID:112566 SPI1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:112737 TAF4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107780 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107780 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Selenium Metabolism and Selenoproteins, organism-specific biosystem (from WikiPathways)
      Selenium Metabolism and Selenoproteins, organism-specific biosystem* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is t...

    Markers

    Homology

    Clone Names

    • MGC17881, MGC41893, MGC111110

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cAMP response element binding protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    glycosphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus NAS
    Non-traceable Author Statement
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cAMP-responsive element modulator
    Names
    cAMP-responsive element modulator
    CREM 2beta-a protein
    CREM 2alpha-b protein
    cAMP response element modulator
    inducible cAMP early repressor ICER

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029065.1 RefSeqGene

      Range
      4969..91086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267562.1NP_001254491.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG573680, BI459432, DA756152
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:118174
      Blast Score: 135
      bZIP_1; bZIP transcription factor
    2. NM_001267563.1NP_001254492.1  cAMP-responsive element modulator isoform 24

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AL157783, BC041810, CB996061, DA756152
      Conserved Domains (1) summary
      pfam00170
      Location:55111
      Blast Score: 111
      bZIP_1; bZIP transcription factor
    3. NM_001267564.1NP_001254493.1  cAMP-responsive element modulator isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BU193626, CD358637
      Consensus CDS
      CCDS58074.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:3975
      Blast Score: 165
      pKID; pKID domain
      pfam00170
      Location:221277
      Blast Score: 125
      bZIP_1; bZIP transcription factor
    4. NM_001267565.1NP_001254494.1  cAMP-responsive element modulator isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BU193626, BU570307, CK300763
      Conserved Domains (2) summary
      pfam02173
      Location:6683
      Blast Score: 74
      pKID; pKID domain
      pfam13900
      Location:2967
      Blast Score: 188
      GVQW; Putative binding domain
    5. NM_001267566.1NP_001254495.1  cAMP-responsive element modulator isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BP370901, BU570307, CK300763
      Conserved Domains (1) summary
      pfam02173
      Location:1450
      Blast Score: 152
      pKID; pKID domain
    6. NM_001267567.1NP_001254496.1  cAMP-responsive element modulator isoform 28

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, BC041810, BG720999, BP370901
      Consensus CDS
      CCDS58075.1
      UniProtKB/TrEMBL
      C9J785
      Conserved Domains (1) summary
      pfam00170
      Location:77133
      Blast Score: 122
      bZIP_1; bZIP transcription factor
    7. NM_001267568.1NP_001254497.1  cAMP-responsive element modulator isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD639591, CD640977, D14826
    8. NM_001267569.1NP_001254498.1  cAMP-responsive element modulator isoform 30

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD640977, D14826
    9. NM_001267570.1NP_001254499.1  cAMP-responsive element modulator isoform 31

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD640465
      Consensus CDS
      CCDS58076.1
      UniProtKB/TrEMBL
      C9JZ10
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:64120
      Blast Score: 98
      bZIP_1; bZIP transcription factor
    10. NM_001881.3NP_001872.3  cAMP-responsive element modulator isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC017117, BC066342, DA756152
      Consensus CDS
      CCDS7184.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363858, OTTHUMP00000019443, ENST00000374726, OTTHUMT00000047551
      Conserved Domains (1) summary
      pfam02173
      Location:5389
      Blast Score: 156
      pKID; pKID domain
    11. NM_181571.2NP_853549.1  cAMP-responsive element modulator isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, BI561543
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000265372, OTTHUMP00000216727, ENST00000345491, OTTHUMT00000357708
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      Blast Score: 165
      pKID; pKID domain
      pfam00170
      Location:239295
      Blast Score: 122
      bZIP_1; bZIP transcription factor
    12. NM_182717.1NP_874386.1  cAMP-responsive element modulator isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS7187.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:60116
      Blast Score: 106
      bZIP_1; bZIP transcription factor
    13. NM_182718.1NP_874387.1  cAMP-responsive element modulator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53519.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:48104
      Blast Score: 107
      bZIP_1; bZIP transcription factor
    14. NM_182719.1NP_874388.1  cAMP-responsive element modulator isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS53517.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:60116
      Blast Score: 106
      bZIP_1; bZIP transcription factor
    15. NM_182720.1NP_874389.1  cAMP-responsive element modulator isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53518.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000349387, OTTHUMP00000216746, ENST00000356917, OTTHUMT00000357740
      Conserved Domains (1) summary
      pfam00170
      Location:48104
      Blast Score: 106
      bZIP_1; bZIP transcription factor
    16. NM_182721.1NP_874390.1  cAMP-responsive element modulator isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS7188.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:52108
      Blast Score: 97
      bZIP_1; bZIP transcription factor
    17. NM_182723.1NP_874392.1  cAMP-responsive element modulator isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814
      Consensus CDS
      CCDS53521.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:4298
      Blast Score: 99
      bZIP_1; bZIP transcription factor
    18. NM_182724.1NP_874393.1  cAMP-responsive element modulator isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS53520.1
      UniProtKB/TrEMBL
      E9PAR4
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      pfam00170
      Location:52108
      Blast Score: 98
      bZIP_1; bZIP transcription factor
    19. NM_182769.2NP_877570.1  cAMP-responsive element modulator isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      Consensus CDS
      CCDS7186.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:1450
      Blast Score: 165
      pKID; pKID domain
      pfam00170
      Location:184240
      Blast Score: 127
      bZIP_1; bZIP transcription factor
    20. NM_182770.2NP_877571.1  cAMP-responsive element modulator isoform 14

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:1450
      Blast Score: 157
      pKID; pKID domain
      pfam00170
      Location:121177
      Blast Score: 110
      bZIP_1; bZIP transcription factor
    21. NM_182771.1NP_877572.1  cAMP-responsive element modulator isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      Consensus CDS
      CCDS7185.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000354593, OTTHUMP00000019448, ENST00000361599, OTTHUMT00000047558
      Conserved Domains (2) summary
      pfam02173
      Location:3975
      Blast Score: 165
      pKID; pKID domain
      pfam00170
      Location:209265
      Blast Score: 126
      bZIP_1; bZIP transcription factor
    22. NM_182772.1NP_877573.1  cAMP-responsive element modulator isoform 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:3975
      Blast Score: 158
      pKID; pKID domain
      pfam00170
      Location:146202
      Blast Score: 111
      bZIP_1; bZIP transcription factor
    23. NM_183011.1NP_898829.1  cAMP-responsive element modulator isoform 21

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS7181.1
      UniProtKB/TrEMBL
      E9PHM1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000333055, ENST00000333809
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      Blast Score: 167
      pKID; pKID domain
      pfam00170
      Location:239295
      Blast Score: 124
      bZIP_1; bZIP transcription factor
    24. NM_183012.1NP_898830.1  cAMP-responsive element modulator isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825
      Consensus CDS
      CCDS31181.1
      UniProtKB/TrEMBL
      A8MPQ2
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000409220, ENST00000439705
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      Blast Score: 162
      pKID; pKID domain
      pfam00170
      Location:176232
      Blast Score: 109
      bZIP_1; bZIP transcription factor
    25. NM_183013.2NP_898831.1  cAMP-responsive element modulator isoform 19

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, DA756152
      Consensus CDS
      CCDS7182.1
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (2) summary
      pfam02173
      Location:69105
      Blast Score: 162
      pKID; pKID domain
      pfam00170
      Location:188244
      Blast Score: 108
      bZIP_1; bZIP transcription factor
    26. NM_183060.2NP_898883.1  cAMP-responsive element modulator isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, AV707433, BC041810, BI561543
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      Q5W1A7
      Related
      ENSP00000363860, ENST00000374728
      Conserved Domains (2) summary
      pfam02173
      Location:5389
      Blast Score: 159
      pKID; pKID domain
      pfam00170
      Location:160216
      Blast Score: 113
      bZIP_1; bZIP transcription factor

    RNA

    1. NR_051971.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has an alternate first exon in place of the first 6 exons and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD686814
    2. NR_051972.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, BC041810, CD686814, DT220562
    3. NR_051973.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has an alternate first exon in place of the first 6 exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AA453346, AL117336, AL157783, BC041810, DA756152
    4. NR_051974.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) has an alternate first exon in place of the first two exons and lacks two other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, AL157783, BC041810, CN367927, DA756152
    5. NR_051975.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32) has an alternate first exon in place of the first two exons and lacks three other exons compared to variant 1. This variant is represented as non-coding because the predicted protein is shorter than 100 aa and there is no support for the existence of this protein.
      Source sequence(s)
      AL117336, AL157783, BC041810, DA756152, DR760671

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000010.10 Reference GRCh37.p10 Primary Assembly

      Range
      35415769..35501886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000142.1 Alternate HuRef

      Range
      35134234..35220214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018921.1 Alternate CHM1_1.0

      Range
      35315717..35401783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182722.1: Suppressed sequence

      Description
      NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_182725.1: Suppressed sequence

      Description
      NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    3. NM_182850.2: Suppressed sequence

      Description
      NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    4. NM_182853.2: Suppressed sequence

      Description
      NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

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