Format

Send to:

Choose Destination

Ereg epiregulin [ Mus musculus (house mouse) ]

Gene ID: 13874, updated on 8-May-2016
Official Symbol
Eregprovided by MGI
Official Full Name
epiregulinprovided by MGI
Primary source
MGI:MGI:107508
See related
Ensembl:ENSMUSG00000029377 Vega:OTTMUSG00000055519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPR
Orthologs
Location:
5; 5 E1
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (91074617..91093649)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91503643..91522675)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene uncharacterized LOC102639958 Neighboring gene epithelial mitogen Neighboring gene amphiregulin Neighboring gene predicted gene, 19619

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC36144

Gene Ontology Provided by MGI

Function Evidence Code Pubs
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
female meiotic division ISO
Inferred from Sequence Orthology
more info
 
keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
luteinizing hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
ovarian cumulus expansion ISO
Inferred from Sequence Orthology
more info
 
ovulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
primary follicle stage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007950.2NP_031976.1  proepiregulin preproprotein

    See identical proteins and their annotated locations for NP_031976.1

    Status: VALIDATED

    Source sequence(s)
    AC109311, BB612312, CJ056327
    Consensus CDS
    CCDS19420.1
    UniProtKB/Swiss-Prot
    Q61521
    Related
    ENSMUSP00000031324, OTTMUSP00000072374, ENSMUST00000031324, OTTMUST00000137419
    Conserved Domains (1) summary
    PHA03099
    Location:58141
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    91074617..91093649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    89212781..89230978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)