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Epn1 epsin 1 [ Mus musculus (house mouse) ]

Gene ID: 13854, updated on 8-May-2016
Official Symbol
Epn1provided by MGI
Official Full Name
epsin 1provided by MGI
Primary source
MGI:MGI:1333763
See related
Ensembl:ENSMUSG00000035203 Vega:OTTMUSG00000026130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibp1; AA269831
Orthologs
Location:
7; 7 A1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (5080203..5098179)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (5031907..5049778)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 106 Neighboring gene predicted gene, 38940 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene ret finger protein-like 4 Neighboring gene RAS-like, family 2, locus 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • EGFR downregulation, organism-specific biosystem (from REACTOME)
    EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC106041

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
epsin-1
Names
EPS-15-interacting protein 1
intersectin-EH-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252454.1NP_001239383.1  epsin-1

    See identical proteins and their annotated locations for NP_001239383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI844312, BC046962, BC067206, CA750240
    Consensus CDS
    CCDS20758.1
    UniProtKB/Swiss-Prot
    Q80VP1
    Related
    ENSMUSP00000043340, OTTMUSP00000032066, ENSMUST00000045277, OTTMUST00000064529
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  2. NM_010147.4NP_034277.1  epsin-1

    See identical proteins and their annotated locations for NP_034277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI844312, BC046962, CA750240
    Consensus CDS
    CCDS20758.1
    UniProtKB/Swiss-Prot
    Q80VP1
    Related
    ENSMUSP00000096445, OTTMUSP00000032065, ENSMUST00000098845, OTTMUST00000064528
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    5080203..5098179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539529.2XP_006539592.2  

    See identical proteins and their annotated locations for XP_006539592.2

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  2. XM_006539532.2XP_006539595.2  

    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  3. XM_006539531.2XP_006539594.2  

    See identical proteins and their annotated locations for XP_006539594.2

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  4. XM_006539533.1XP_006539596.1  

    See identical proteins and their annotated locations for XP_006539596.1

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  5. XM_006539535.1XP_006539598.1  

    See identical proteins and their annotated locations for XP_006539598.1

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  6. XM_006539534.1XP_006539597.1  

    See identical proteins and their annotated locations for XP_006539597.1

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  7. XM_006539536.1XP_006539599.1  

    See identical proteins and their annotated locations for XP_006539599.1

    UniProtKB/Swiss-Prot
    Q80VP1
    Related
    ENSMUSP00000146638, OTTMUSP00000076247, ENSMUST00000208634, OTTMUST00000146452
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  8. XM_006539537.1XP_006539600.1  

    Conserved Domains (2) summary
    pfam02809
    Location:105122
    UIM; Ubiquitin interaction motif
    cl02544
    Location:164
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  9. XM_011250434.1XP_011248736.1  

    See identical proteins and their annotated locations for XP_011248736.1

    UniProtKB/Swiss-Prot
    Q80VP1
    Conserved Domains (2) summary
    pfam02809
    Location:182199
    UIM; Ubiquitin interaction motif
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  10. XM_006539538.1XP_006539601.1  

    Conserved Domains (1) summary
    PRK07764
    Location:74200
    PRK07764; DNA polymerase III subunits gamma and tau; Validated

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    4822319..4840264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)