TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like [Homo sapiens] - Gene

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Summary

Official Symbol: TAF1Lprovided by HGNC
Official Full Name: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-likeprovided by HGNC
Primary source: HGNC:18056
See related: Ensembl:ENSG00000122728; HPRD:09696; MIM:607798; Vega:OTTHUMG00000019747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TAF2A2; MGC134910
Summary: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2009]

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Genomic context

Location :: 9p21.1

Sequence :: Chromosome: 9; NC_000009.11 (32629452..32635667, complement)

See TAF1L in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Arose by retroposition of a processed TAF(II)250 mRNA during primate evolution, replaces its function only in male meiosis.
Title: Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q8IZX4	P20226	TBP	HPRD	PubMed
BioGRID:126514	BioGRID:112771	TBP	BioGRID	PubMed	Two-hybrid
BioGRID:126514	BioGRID:114896	TBPL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:126514	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
histone acetylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
male meiosis	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription initiation, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
nucleus	IEA Inferred from Electronic Annotation more info
transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: transcription initiation factor TFIID subunit 1-like

Names: transcription initiation factor TFIID subunit 1-like; TAF(II)210; TBP-associated factor 1-like; TBP-associated factor 210 kDa; TBP-associated factor RNA polymerase 1-like; transcription initiation factor TFIID 210 kDa subunit

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153809.2 → NP_722516.1 transcription initiation factor TFIID subunit 1-like

Status: PROVISIONAL

Source sequence(s)

AF390562

Consensus CDS

CCDS35003.1

UniProtKB/Swiss-Prot

Q8IZX4

Related

ENSP00000418379, OTTHUMP00000215933, ENST00000242310, OTTHUMT00000052012

Conserved Domains (3) summary

cd05511
Location:1526 – 1638
Blast Score: 488

Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...

pfam09247
Location:34 – 86
Blast Score: 172

TBP-binding; TATA box-binding protein binding

cl15417
Location:584 – 1047
Blast Score: 1561

DUF3591; Protein of unknown function (DUF3591)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

32629452..32635667, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

32586240..32592455, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL589642.6 (13821..20036)	None
mRNA	AF390562.1	AAN40840.1
mRNA	BC116181.1	None
mRNA	BC116182.1	None
other-genetic	BC172227.1	AAI72227.1