Ephb3 Eph receptor B3 [Mus musculus] - Gene

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Summary

Official Symbol: Ephb3provided by MGI
Official Full Name: Eph receptor B3provided by MGI
Primary source: MGI:104770
See related: Ensembl:ENSMUSG00000005958; Vega:OTTMUSG00000035120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Etk2; HEK2; MDK5; Sek4; Cek10; Tyro6; AW456895

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Genomic context

Location :: 16; 16 B1-B4

Sequence :: Chromosome: 16; NC_000082.6 (21204795..21223304)

See Ephb3 in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EphB-deficient SCID chimeras show profoundly altered thymic epithelial organization that confirms a significant role for EphB2 and EphB3 receptors in the thymocyte-TEC crosstalk.
Title: The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus.
These results demonstrate that EphB receptors influence auditory cortical responses, and suggest that EphB signaling has multiple functions in auditory system development.
Title: Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.
Data suggest that both EphB2 and EphB3 receptors are required coordinately for pancreatic development.
Title: Epithelial dynamics of pancreatic branching morphogenesis.
tumor suppressor p53 expression was increased following EphB3 stimulation and is reduced in the absence of either EphB3 or ephrinB3.
Title: EphB3 limits the expansion of neural progenitor cells in the subventricular zone by regulating p53 during homeostasis and following traumatic brain injury.
A trans-synaptic interaction between EphB2 in the presynaptic compartment and ephrin-B3 in the postsynaptic compartment regulates synapse density and the formation of dendritic spines.
Title: Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling.
Results demonstrate an autonomous role for both EphB2 and EphB3 in the control of thymic epithelial cell development and support the relevance of EphB2 forward signaling in the process.
Title: Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization.
comparative analysis of WT and EphB2/B3-deficient embryonic and newborn thymi demonstrated that the observed adult phenotype was a consequence of the gradual accumulation of early phenotypic and morphological defects
Title: On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network.
mutants of EphB2 and EphB3 receptor genes displayed a morphological defect in the ventral midbrain
Title: EphB receptor tyrosine kinases control morphological development of the ventral midbrain.
These data establish EphB receptors as key coordinators of migration and proliferation in the intestinal stem cell niche.
Title: EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.
RYK regulates cell migration during mammalian cortical development through the binding to Eph receptors
Title: Receptor related to tyrosine kinase RYK regulates cell migration during cortical development.

Submit: New GeneRIF Correction See all (13)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
axon guidance receptor activity	IDA Inferred from Direct Assay more info	PubMed
ephrin receptor activity	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transmembrane-ephrin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
axon guidance	IDA Inferred from Direct Assay more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	ISO Inferred from Sequence Orthology more info
central nervous system projection neuron axonogenesis	IDA Inferred from Direct Assay more info	PubMed
corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info
palate development	IMP Inferred from Mutant Phenotype more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of Cdc42 GTPase activity	ISO Inferred from Sequence Orthology more info
regulation of Rac GTPase activity	ISO Inferred from Sequence Orthology more info
regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
urogenital system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cell projection	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	ISO Inferred from Sequence Orthology more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ephrin type-B receptor 3

Names: ephrin type-B receptor 3; mDK-5; developmental kinase 5; tyrosine-protein kinase receptor SEK-4

NP_034273.1

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010143.1 → NP_034273.1 ephrin type-B receptor 3 precursor

Status: PROVISIONAL

Source sequence(s)

BC053085

Consensus CDS

CCDS28060.1

UniProtKB/Swiss-Prot

P54754

Related

ENSMUSP00000006112, OTTMUSP00000048842, ENSMUST00000006112, OTTMUST00000089377

Conserved Domains (7) summary

cd00063
Location:468 – 537
Blast Score: 142

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07699
Location:276 – 308
Blast Score: 105

GCC2_GCC3; GCC2 and GCC3

cd05065
Location:623 – 891
Blast Score: 1568

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd10478
Location:31 – 203
Blast Score: 959

EphR_LBD_B3; Ligand Binding Domain of Ephrin type-B Receptor 3

pfam07647
Location:917 – 982
Blast Score: 230

SAM_2; SAM domain (Sterile alpha motif)

pfam07714
Location:628 – 887
Blast Score: 1049

Pkinase_Tyr; Protein tyrosine kinase

cl15755
Location:917 – 985
Blast Score: 364

SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38 C57BL/6J

Range

21204795..21223304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

21770110..21788619

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC168061.3 (22507..41016)	None
genomic	CH466521.1	EDK97600.1	mixed
		EDK97601.1	mixed
mRNA	AK144414.1	None	C57BL/6J
mRNA	AK158043.1	BAE34333.1	C57BL/6J
mRNA	BC014822.1	AAH14822.1	FVB/N
mRNA	BC027805.1	None	FVB/N
mRNA	BC053085.1	AAH53085.1	C57BL/6
mRNA	U11493.1	AAA67925.1
mRNA	X76012.1	CAA53599.1	BALB/c
mRNA	Z49086.1	CAA88910.1	BALB/c

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P54754.2	GenPept	UniProtKB/Swiss-Prot:P54754
Q3TZ77	GenPept	UniProtKB/TrEMBL:Q3TZ77
Q60669	GenPept	UniProtKB/TrEMBL:Q60669