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    PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Homo sapiens ]

    Gene ID: 138429, updated on 19-May-2012
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    Summary

    Official Symbol
    PIP5KL1provided by HGNC
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase-like 1provided by HGNC
    Primary source
    HGNC:28711
    Locus tag
    RP11-203J24.5
    See related
    Ensembl:ENSG00000167103; HPRD:15139; MIM:612865; Vega:OTTHUMG00000020719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIPKH; bA203J24.5; MGC46424; RP11-203J24.5
    Summary
    PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]
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    Genomic context

    Location :
    9q34.11
    Sequence :
    Chromosome: 9; NC_000009.11 (130683808..130693076, complement)
    See PIP5KL1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit Neighboring gene family with sequence similarity 102, member A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Shi L, et al. Mol Biol Rep, 2010 Jun. PMID 19680787.
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.
    3. Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, et al. J Biol Chem, 2004 Mar 19. PMID 14701839.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These studies indicate a functional negative correlation between elevated levels of PIP5KL1 and the development of human gastric cancer.
      Title: Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells.
    2. PIPKH acts as a scaffold to localize and regulate type I PI(4)P 5-kinases and the synthesis of PI(3,4,5)P(3)
      Title: Identification and characterization of a phosphoinositide phosphate kinase homolog.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Phosphatidylinositol-4-phosphate 5-kinase-like 1 Q99755 PIP5K1A    HPRD  PubMed  
    Phosphatidylinositol-4-phosphate 5-kinase-like 1 O14986 PIP5K1B    HPRD  PubMed  
    BioGRID:126513 BioGRID:113983 PIP5K1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:126513 BioGRID:113984 PIP5K1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:126513 BioGRID:116969 PIP5K1C    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Names
    phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    PI(4)P 5-kinase-like protein 1
    ptdIns(4)P-5-kinase-like protein 1
    phosphatidylinositol phosphate kinase homolog
    phosphatidylinositol-4-phosphate 5-kinase-like protein 1
    NP_001128691.1
    NP_775763.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135219.1 → NP_001128691.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL157935, BC042184, BE881330
      Consensus CDS
      CCDS48030.1
      UniProtKB/Swiss-Prot
      Q5T9C9
      Related
      ENSP00000373399, OTTHUMP00000022215, ENST00000388747, OTTHUMT00000054289
      Conserved Domains (1) summary
      cl02572
      Location:59 – 390
      Blast Score: 422
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

    2. NM_173492.1 → NP_775763.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks several 5' exons and has an alternate 5' segment, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      BC042184
      Consensus CDS
      CCDS6885.1
      UniProtKB/Swiss-Prot
      Q5T9C9
      Related
      ENSP00000300432, OTTHUMP00000162380, ENST00000300432, OTTHUMT00000054295
      Conserved Domains (1) summary
      cl02572
      Location:1 – 187
      Blast Score: 235
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      130683808..130693076, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      100300746..100310021, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL157935.28 CAI12614.2
      CAM14148.1
    genomic CH471090.1 EAW87722.1
      EAW87723.1
      EAW87724.1
      EAW87725.1
      EAW87726.1
      EAW87727.1
      EAW87728.1
    mRNA BC042184.1 AAH42184.1
    mRNA BE881330.1 None
    other-genetic HQ448498.1 ADQ32978.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T9C9.2 GenPept UniProtKB/Swiss-Prot:Q5T9C9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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