CRABP2 cellular retinoic acid binding protein 2 [Homo sapiens] - Gene

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Summary

Official Symbol: CRABP2provided by HGNC
Official Full Name: cellular retinoic acid binding protein 2provided by HGNC
Primary source: HGNC:2339
Locus tag: RP11-66D17.4
See related: Ensembl:ENSG00000143320; HPRD:08353; MIM:180231; Vega:OTTHUMG00000041300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RBP6; CRABP-II
Summary: This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

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Genomic context

Location :: 1q21.3

Sequence :: Chromosome: 1; NC_000001.10 (156669398..156675608, complement)

See CRABP2 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low CRABP2 is associated with pancreatic ductal adenocarcinoma.
Title: Molecular determinants of retinoic acid sensitivity in pancreatic cancer.
Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation
Title: Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation.
Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure.
Title: Impaired expansion of trophoblast spheroids cocultured with endometrial cells overexpressing cellular retinoic acid-binding protein 2.
Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation.
Title: Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.
Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis.
Title: Newborn serum retinoic acid level is associated with variants of genes in the retinol metabolism pathway.
Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial.
Data sghow a higher frequency of CRABP2 and MX1 hypermethylation in primary HNSCC when compared with lymphocytes from healthy individuals.
Title: Epigenetic silencing of CRABP2 and MX1 in head and neck tumors.
Derangement/lack of a critical factor necessary for RARalpha function induces epigenetic repression of a RA-regulated gene network downstream of RARalpha, with major pleiotropic biological outcomes.
Title: Derangement of a factor upstream of RARalpha triggers the repression of a pleiotropic epigenetic network.
MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development.
Title: Regulation of CRABP-II expression by MycN in Wilms tumor.
Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells.
Title: Retinoids regulate genes involved in retinoic acid synthesis and transport in human myometrial and fibroid smooth muscle cells.

Submit: New GeneRIF Correction See all (23)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001869.1			BIND	PubMed	CRABP-II interacts with RA.
NP_001869.1			BIND	PubMed	CRABP-II (cellular retinoic acid-binding protein II) interacts with RA (all-trans-retinoic acid).
P29373	P30281	CCND3	HPRD	PubMed
P29373	P29373	CRABP2	HPRD	PubMed
BioGRID:107773	BioGRID:107336	CCND3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107773	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107773	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
lipid binding	IEA Inferred from Electronic Annotation more info
retinal binding	IEA Inferred from Electronic Annotation more info
retinoic acid binding	IEA Inferred from Electronic Annotation more info
retinoid binding	TAS Traceable Author Statement more info	PubMed
retinol binding	IEA Inferred from Electronic Annotation more info
transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
epidermis development	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
retinoic acid metabolic process	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: cellular retinoic acid-binding protein 2

Names: cellular retinoic acid-binding protein 2; cellular retinoic acid-binding protein II

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199723.1 → NP_001186652.1 cellular retinoic acid-binding protein 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR and encodes the same protein, as compared to variant 1.

Source sequence(s)

AU126559, BC001109

Consensus CDS

CCDS1152.1

UniProtKB/TrEMBL

F1T098

UniProtKB/Swiss-Prot

P29373

Related

ENSP00000357204, OTTHUMP00000038732, ENST00000368221, OTTHUMT00000098968

Conserved Domains (1) summary

cl01150
Location:5 – 138
Blast Score: 142

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
NM_001878.3 → NP_001869.1 cellular retinoic acid-binding protein 2

Status: REVIEWED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AK312007, BC001109, BP231157

Consensus CDS

CCDS1152.1

UniProtKB/TrEMBL

F1T098

UniProtKB/Swiss-Prot

P29373

Related

ENSP00000357205, OTTHUMP00000038730, ENST00000368222, OTTHUMT00000098966

Conserved Domains (1) summary

cl01150
Location:5 – 138
Blast Score: 142

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

156669398..156675608, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

128026950..128033158, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL590666.8	CAI16339.1
		CAI16340.1
genomic	CH471121.2	EAW52921.1
		EAW52922.1
genomic	M97815.1	AAA58430.1
mRNA	AB593017.1	BAJ83972.1
mRNA	AK312007.1	BAG34945.1
mRNA	AU126559.1	None
mRNA	BC001109.2	AAH01109.1
mRNA	BP231157.1	None
mRNA	BT019827.1	AAV38630.1
mRNA	CR450357.1	CAG29353.1
mRNA	M68867.1	AAA52068.1
other-genetic	DQ892265.2	ABM83191.1
other-genetic	DQ896851.2	ABM87850.1