Eno2 enolase 2, gamma neuronal [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Eno2provided by MGI
Official Full Name: enolase 2, gamma neuronalprovided by MGI
Primary source: MGI:95394
See related: Ensembl:ENSMUSG00000004267; Vega:OTTMUSG00000022240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NSE; Eno-2; AI837106; D6Ertd375e

Genomic context

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Location :: 6 F2; 6 59.17 cM

Sequence :: Chromosome: 6; NC_000072.6 (124760055..124769509, complement)

See Eno2 in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Treadmill exercise training decreased the expression of NSN in the striatum of chronic Parkinsonian mice, which can partially explain the beneficial neuroprotective role of exercise in patients with parkinson disease.
Title: Effect of endurance exercise training on the expression of GFAP, S100B, and NSE in the striatum of chronic/progressive mouse model of Parkinson's disease.
we induced differentiation of mouse stromal cells to neuron-like cells and observed the activation of tissue-specific promoter of neuron-specific enolase in transgenic mice with the human bcl-2 gene expressed only in neurons under the NSE promoter
Title: Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-in) (1) 1 citation

Pathways from BioSystems

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Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
Biosynthesis of amino acids, organism-specific biosystem
Biosynthesis of amino acids
Biosynthesis of amino acids, conserved biosystem (from KEGG)
Biosynthesis of amino acids, conserved biosystem
Biosynthesis of amino acids
Gluconeogenesis, organism-specific biosystem (from REACTOME)
Gluconeogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem (from KEGG)
Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem (from KEGG)
Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glucose metabolism, organism-specific biosystem (from REACTOME)
Glucose metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis, organism-specific biosystem (from REACTOME)
Glycolysis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
Glycolysis, core module involving three-carbon compounds, organism-specific biosystem (from KEGG)
Glycolysis, core module involving three-carbon compounds, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis, core module involving three-carbon compounds, conserved biosystem (from KEGG)
Glycolysis, core module involving three-carbon compounds, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA degradation, organism-specific biosystem (from KEGG)
RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
RNA degradation, conserved biosystem (from KEGG)
RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

General gene information

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Markers

AI837106 (e-PCR)
- UniSTS:179460

Eno2 (e-PCR), detects polymorphism
- UniSTS:516632

RH127101 (e-PCR)
- UniSTS:167482

MARC_4643-4644:966894536:1 (e-PCR)
- UniSTS:269413

Eno2 (e-PCR), detects polymorphism
- UniSTS:142991

UniSTS:142992 (e-PCR)
- UniSTS:142992

Eno2 (e-PCR), detects polymorphism
- UniSTS:142992

BB431127 (e-PCR)
- UniSTS:208033

Eno2 (e-PCR), detects polymorphism
- UniSTS:265660

Eno2 (e-PCR), detects polymorphism
- UniSTS:506879

Homology

Homologs of the Eno2 gene: The Eno2 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
lyase activity	IEA Inferred from Electronic Annotation more info
magnesium ion binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
phosphopyruvate hydratase activity	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
gluconeogenesis	ISO Inferred from Sequence Orthology more info
glycolysis	ISO Inferred from Sequence Orthology more info
metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
neuron projection	ISO Inferred from Sequence Orthology more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
perikaryon	IDA Inferred from Direct Assay more info	PubMed
phosphopyruvate hydratase complex	IEA Inferred from Electronic Annotation more info
photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-enolase

Names: gamma-enolase; neural enolase; neuron-specific enolase; 2-phospho-D-glycerate hydro-lyase

NP_038537.1

EC 4.2.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013509.2 → NP_038537.1 gamma-enolase

Status: PROVISIONAL

Source sequence(s)

BC031739

Consensus CDS

CCDS20527.1

UniProtKB/Swiss-Prot

P17183

UniProtKB/TrEMBL

Q545V3

Related

ENSMUSP00000004378, OTTMUSP00000025146, ENSMUST00000004378, OTTMUST00000052923

Conserved Domains (2) summary

cd03313
Location:5 – 416
Blast Score: 1801

enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

PLN00191
Location:2 – 432
Blast Score: 2067

PLN00191; enolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p1 C57BL/6J

Range

124760055..124769509, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

126441787..126451238, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01057229.1 (91916..101367)	None
genomic	AC002397.1	AAC36002.1
genomic	AC164157.3 (155926..165380)	None
genomic	CH466523.1	EDK99756.1	mixed
		EDK99757.1	mixed
		EDK99758.1	mixed
genomic	HC893853.1	CBN61371.1
mRNA	AK003051.1	BAB22533.1	C57BL/6J
mRNA	AK131652.1	BAE20741.1	C57BL/6J
mRNA	AK134571.1	None	C57BL/6J
mRNA	AK146655.1	BAE27335.1	C57BL/6J
mRNA	AK170169.1	None	NOD
mRNA	BC009018.1	AAH09018.1	FVB/N
mRNA	BC031739.1	AAH31739.1
mRNA	BC043708.1	None
mRNA	X52380.1	CAA36606.1