Eno1 enolase 1, alpha non-neuron [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Eno1provided by MGI
Official Full Name: enolase 1, alpha non-neuronprovided by MGI
Primary source: MGI:95393
See related: Ensembl:ENSMUSG00000063524; Vega:OTTMUSG00000010390
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eno-1; MBP-1; AL022784; 0610008I15

Genomic context

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Location :: 4 E2; 4 81.24 cM

Sequence :: Chromosome: 4; NC_000070.6 (150237197..150248873)

See Eno1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

ENO1-positive monocytes and macrophages are found in arthritic ankle tissues of mice with collagen-induced arthritis.
Title: α-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis.
enolase 1 and calreticulin are important proteins in regulating the differentiation and functions of bone marrow mast cells
Title: Enolase 1 and calreticulin regulate the differentiation and function of mouse mast cells.
the expression of alpha-enolase plasminogen receptor may serve to concentrate and enhance plasmin generation on the cell surface of migratory myoblasts contributing to efficient muscle repair [review]
Title: Alpha-enolase plasminogen receptor in myogenesis.
plasminogen stimulated DNA binding activity of the transcription factors activator-protein 1 and early growth response gene-1 to their cognate regulatory sequences at alpha-enolase promoter
Title: Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathway.
By concentrating and enhancing plasmin generation on the cell surface, alpha-enolase-type plasminogen receptor is an important component of skeletal myogenesis.
Title: Plasmin generation dependent on alpha-enolase-type plasminogen receptor is required for myogenesis.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:199451	BioGRID:214495	Cabyr	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199451	BioGRID:212401	Fbxo32	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199451	BioGRID:199773	Fyn	BioGRID	PubMed	Biochemical Activity
BioGRID:199451	BioGRID:240592	Neurl2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199451	BioGRID:207808	Set	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199451	BioGRID:203491	Src	BioGRID	PubMed	Biochemical Activity
BioGRID:199451	BioGRID:204307	Traf6	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:199451	BioGRID:204623	Ywhaz	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
Biosynthesis of amino acids, organism-specific biosystem
Biosynthesis of amino acids
Biosynthesis of amino acids, conserved biosystem (from KEGG)
Biosynthesis of amino acids, conserved biosystem
Biosynthesis of amino acids
Gluconeogenesis, organism-specific biosystem (from REACTOME)
Gluconeogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem (from KEGG)
Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem (from KEGG)
Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glucose metabolism, organism-specific biosystem (from REACTOME)
Glucose metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis, organism-specific biosystem (from REACTOME)
Glycolysis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystem (from KEGG)
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
Glycolysis, core module involving three-carbon compounds, organism-specific biosystem (from KEGG)
Glycolysis, core module involving three-carbon compounds, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Glycolysis, core module involving three-carbon compounds, conserved biosystem (from KEGG)
Glycolysis, core module involving three-carbon compounds, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA degradation, organism-specific biosystem (from KEGG)
RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
RNA degradation, conserved biosystem (from KEGG)
RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...

General gene information

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Markers

AI427012 (e-PCR)
- UniSTS:165376

Eno1 (e-PCR), detects polymorphism
- UniSTS:546755

RH125429 (e-PCR)
- UniSTS:162251

Homology

Homologs of the Eno1 gene: The Eno1 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and A.thaliana.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
phosphopyruvate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
phosphopyruvate hydratase activity	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cellular response to acid	IDA Inferred from Direct Assay more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
metabolic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of binding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
extracellular vesicular exosome	ISO Inferred from Sequence Orthology more info
extrinsic to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
neuron projection	ISO Inferred from Sequence Orthology more info
synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-enolase

Names: alpha-enolase; NNE; non-neural enolase; c-Myc promoter binding protein; 2-phospho-D-glycerate hydrolase; 2-phospho-D-glycerate hydro-lyase

NP_075608.2

EC 4.2.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023119.2 → NP_075608.2 alpha-enolase

Status: VALIDATED

Source sequence(s)

BC083334, BU526382

Consensus CDS

CCDS18971.1

UniProtKB/Swiss-Prot

P17182

UniProtKB/TrEMBL

Q5FW97

Related

ENSMUSP00000079727, OTTMUSP00000011140, ENSMUST00000080926, OTTMUST00000024224

Conserved Domains (2) summary

cd03313
Location:5 – 416
Blast Score: 1783

enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.

PLN00191
Location:2 – 432
Blast Score: 2041

PLN00191; enolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p1 C57BL/6J

Range

150237197..150248873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 NOD/MrkTac

Genomic

NT_187025.1 Reference GRCm38.p1 NOD/MrkTac

Range

544191..555859

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

152512235..152523950

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01042068.1 (6896..15372)	None
genomic	AAHY01042069.1	None
genomic	AL606903.8 (59153..70829)	None
genomic	CU207373.6 (32735..44403)	None	ZRU
mRNA	AK002322.1	BAC24987.1	C57BL/6J
mRNA	AK002336.1	BAB22021.1	C57BL/6J
mRNA	AK014335.1	None	C57BL/6J
mRNA	AK088788.1	BAC40572.1	NOD
mRNA	AK147987.1	BAE28270.1	C57BL/6J
mRNA	AK150161.1	BAE29351.1	C57BL/6J
mRNA	AK150192.1	BAE29369.1	C57BL/6J
mRNA	AK153321.1	BAE31901.1	C57BL/6J
mRNA	AK177990.1	None
mRNA	AK180361.1	None
mRNA	AK186626.1	None
mRNA	AK190122.1	None
mRNA	AK190320.1	None
mRNA	AK190571.1	None
mRNA	AK190836.1	None
mRNA	AK190994.1	None
mRNA	AK191162.1	None
mRNA	AK191266.1	None
mRNA	AK191599.1	None
mRNA	AK192110.1	None
mRNA	AK192771.1	None
mRNA	AK192856.1	None
mRNA	AK193395.1	None
mRNA	AK193470.1	None
mRNA	AK193472.1	None
mRNA	AK194042.1	None
mRNA	AK194050.1	None
mRNA	AK194112.1	None
mRNA	AK194157.1	None
mRNA	AK194312.1	None
mRNA	AK194383.1	None
mRNA	AK194493.1	None
mRNA	AK194536.1	None
mRNA	AK194989.1	None
mRNA	AK195184.1	None
mRNA	AK195411.1	None
mRNA	AK195645.1	None
mRNA	AK196033.1	None
mRNA	AK196278.1	None
mRNA	AK196762.1	None
mRNA	AK196851.1	None
mRNA	AK196981.1	None
mRNA	AK197358.1	None
mRNA	AK197783.1	None
mRNA	AK198256.1	None
mRNA	AK198771.1	None
mRNA	AK198960.1	None
mRNA	AK199229.1	None
mRNA	AK199273.1	None
mRNA	AK199394.1	None
mRNA	AK199498.1	None
mRNA	AK199950.1	None
mRNA	AK199973.1	None
mRNA	AK200096.1	None
mRNA	AK201180.1	None
mRNA	AK201655.1	None
mRNA	AK202010.1	None
mRNA	AK202164.1	None
mRNA	AK202376.1	None
mRNA	AK202428.1	None
mRNA	AK202490.1	None
mRNA	AK202509.1	None
mRNA	AK202755.1	None
mRNA	AK202928.1	None
mRNA	AK203149.1	None
mRNA	AK203172.1	None
mRNA	AK203740.1	None
mRNA	AK204087.1	None
mRNA	AK204111.1	None
mRNA	AK204457.1	None
mRNA	AK204692.1	None
mRNA	AK204945.1	None
mRNA	AK204949.1	None
mRNA	AK206473.1	None
mRNA	AK207175.1	None
mRNA	AK207837.1	None
mRNA	AK208860.1	None
mRNA	AK211315.1	None
mRNA	AK211960.1	None
mRNA	AK214077.1	None
mRNA	AK217406.1	None
mRNA	AK218216.1	None
mRNA	AK219016.1	None
mRNA	AK219721.1	None
mRNA	BC003891.1	AAH03891.1	FVB/N
mRNA	BC003934.1	None
mRNA	BC010685.1	AAH10685.1	FVB/N
mRNA	BC024644.1	AAH24644.1	FVB/N
mRNA	BC039179.1	AAH39179.2
mRNA	BC056611.1	AAH56611.1	FVB/N
mRNA	BC083334.1	AAH83334.2	C57BL/6
mRNA	BC085098.1	AAH85098.1	FVB/N-3
mRNA	BU526382.1	None
mRNA	X52379.1	CAA36605.1