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En1 engrailed 1 [ Mus musculus (house mouse) ]

Gene ID: 13798, updated on 17-May-2016
Official Symbol
En1provided by MGI
Official Full Name
engrailed 1provided by MGI
Primary source
MGI:MGI:95389
See related
Ensembl:ENSMUSG00000058665 Vega:OTTMUSG00000037271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
En-1; Mo-en.1
Orthologs
Location:
1 52.74 cM; 1 C2-qter
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (120602391..120607991)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (122499064..122504568)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene macrophage receptor with collagenous structure Neighboring gene predicted gene, 41939 Neighboring gene RIKEN cDNA 2610027F03 gene Neighboring gene predicted gene, 34352 Neighboring gene predicted gene 29345

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Dopminergic Neurogenesis, organism-specific biosystem (from WikiPathways)
    Dopminergic Neurogenesis, organism-specific biosystemhttp://www.michaeljfox.org/research_MJFFfundingPortfolio_searchableAwardedGrants_3.cfm?ID=141
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IGI
Inferred from Genetic Interaction
more info
PubMed 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
motor learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
homeobox protein engrailed-1
Names
engrailed-1
homeobox protein en-1
mo-En-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010133.2NP_034263.2  homeobox protein engrailed-1

    See identical proteins and their annotated locations for NP_034263.2

    Status: VALIDATED

    Source sequence(s)
    AC133286, AK140408, AK140634, BY727637
    Consensus CDS
    CCDS15235.1
    UniProtKB/Swiss-Prot
    P09065
    UniProtKB/TrEMBL
    Q3USA2
    Related
    ENSMUSP00000078659, OTTMUSP00000053676, ENSMUST00000079721, OTTMUST00000096137
    Conserved Domains (2) summary
    pfam10525
    Location:370401
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain
    cd00086
    Location:314369
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    120602391..120607991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247922.1XP_011246224.1  

    Conserved Domains (2) summary
    pfam10525
    Location:384415
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain
    cd00086
    Location:328383
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    123260515..123266033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)