CKS1BP7 CDC28 protein kinase regulatory subunit 1B pseudogene 7 [Homo sapiens] - Gene

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Summary

Official Symbol: CKS1BP7provided by HGNC
Official Full Name: CDC28 protein kinase regulatory subunit 1B pseudogene 7provided by HGNC
Primary source: HGNC:1999
Gene type: pseudo
RefSeq status: INFERRED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKS1; CKS1A

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Genomic context

Location :: 8q21.13

Sequence :: Chromosome: 8; NC_000008.10 (81556687..81557451, complement)

See CKS1BP7 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that mtSSB bound both CKS1 and CKS2 and underwent CDK-dependent phosphorylation.
Title: CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.
Cks1 levels regulate the responsiveness of ER+ breast cancers to estrogens and anti-estrogens.
Title: High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1.
Data show that cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Title: Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Elevated expression of Cks1 may contribute to prostate tumorigenesis by promoting proliferation, anchorage-independent growth and migration of the cells, and elevated expression of Cks2 by protecting cells from undergoing programmed cell death.
Title: Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death.
Results suggest that CKS1 has a supporting role for SKP2 (S-phase kinase-associated protein 2) function in human urothelial carcinoma.
Title: Increased SKP2 and CKS1 gene expression contributes to the progression of human urothelial carcinoma.
induction of Skp2 and Cks1 degradation in G1 represents a principal mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and maintains the G1 state
Title: Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:126480	BioGRID:107331	CCNA2	BioGRID	PubMed	Biochemical Activity
BioGRID:126480	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:126480	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

General gene information

Related functional gene

Review record(s) in Gene

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General protein information

Preferred Names: CDC28 protein kinase regulatory subunit 1A

Names: CDC28 protein kinase regulatory subunit 1A

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.