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Egr2 early growth response 2 [ Mus musculus (house mouse) ]

Gene ID: 13654, updated on 22-May-2016
Official Symbol
Egr2provided by MGI
Official Full Name
early growth response 2provided by MGI
Primary source
MGI:MGI:95296
See related
Ensembl:ENSMUSG00000037868 Vega:OTTMUSG00000033571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Egr-2; Zfp-6; Krox20; NGF1-B; Zfp-25; Krox-20
Orthologs
Location:
10 34.96 cM; 10 B5
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (67534456..67542188)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (67000617..67004936)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32255 Neighboring gene predicted gene, 40679 Neighboring gene predicted gene, 32176 Neighboring gene 2-aminoethanethiol (cysteamine) dioxygenase Neighboring gene uncharacterized LOC105245193

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
facial nerve structural organization IGI
Inferred from Genetic Interaction
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
rhombomere 3 development IGI
Inferred from Genetic Interaction
more info
PubMed 
rhombomere 3 formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhombomere 5 formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic behavior IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 SUMO-protein ligase EGR2
Names
early growth response protein 2
zinc finger protein Krox-20

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010118.3NP_034248.2  E3 SUMO-protein ligase EGR2

    See identical proteins and their annotated locations for NP_034248.2

    Status: VALIDATED

    Source sequence(s)
    AK155585, BY742929, X06746
    Consensus CDS
    CCDS35927.2
    UniProtKB/Swiss-Prot
    P08152
    UniProtKB/TrEMBL
    Q3U207
    Related
    ENSMUSP00000041053, OTTMUSP00000045576, ENSMUST00000048289, OTTMUST00000084546
    Conserved Domains (5) summary
    COG5048
    Location:365421
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:337361
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:94184
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:381406
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:339361
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    67534456..67542188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243366.1XP_011241668.1  

    See identical proteins and their annotated locations for XP_011241668.1

    Conserved Domains (5) summary
    COG5048
    Location:378434
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:350374
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:107197
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:352374
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011243367.1XP_011241669.1  

    See identical proteins and their annotated locations for XP_011241669.1

    Conserved Domains (5) summary
    COG5048
    Location:378434
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:350374
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:107197
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:352374
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_006513208.2XP_006513271.1  

    Conserved Domains (5) summary
    COG5048
    Location:479535
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:451475
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:208298
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:495520
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:453475
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011243368.1XP_011241670.1  

    See identical proteins and their annotated locations for XP_011241670.1

    UniProtKB/Swiss-Prot
    P08152
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_006513210.1XP_006513273.1  

    See identical proteins and their annotated locations for XP_006513273.1

    UniProtKB/Swiss-Prot
    P08152
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_006513209.1XP_006513272.1  

    See identical proteins and their annotated locations for XP_006513272.1

    UniProtKB/Swiss-Prot
    P08152
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_006513213.2XP_006513276.1  

    See identical proteins and their annotated locations for XP_006513276.1

    UniProtKB/Swiss-Prot
    P08152
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_006513211.1XP_006513274.1  

    See identical proteins and their annotated locations for XP_006513274.1

    UniProtKB/Swiss-Prot
    P08152
    Related
    ENSMUSP00000101078, OTTMUSP00000045577, ENSMUST00000105438, OTTMUST00000084547
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_006513212.1XP_006513275.1  

    See identical proteins and their annotated locations for XP_006513275.1

    UniProtKB/Swiss-Prot
    P08152
    Conserved Domains (5) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44134
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:331356
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    68629352..68633671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)