Egr1 early growth response 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Egr1provided by MGI
Official Full Name: early growth response 1provided by MGI
Primary source: MGI:95295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik

Genomic context

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Location :: 18 C/D; 18 18.76 cM

Sequence :: Chromosome: 18; NC_000084.6 (34861207..34864956)

See Egr1 in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

A newly identified microRNA, mmu-miR-7578, functions as a negative regulator on inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 via targeting Egr1 in vivo.
Title: A newly identified microRNA, mmu-miR-7578, functions as a negative regulator on inflammatory cytokines tumor necrosis factor-α and interleukin-6 via targeting Egr1 in vivo.
Decrease in Egr-1 expression in the frontal cortex may be involved in social isolation stress-induced behavioral abnormalities.
Title: Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice.
interaction between EGR1 and SIRT1 describes an autoregulatory loop that shuts down the stretch-induced Sirt1 expression
Title: An autoregulatory loop reverts the mechanosensitive Sirt1 induction by EGR1 in skeletal muscle cells.
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Title: Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Title: Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
Acute EtOH administration induced the synthesis of Egr-1 in mouse liver.
Title: Early growth response-1 contributes to steatosis development after acute ethanol administration.
In lateral periaqueductal gray, virgin mice showed a significant Egr-1 increase with neurotensin (relative to vehicle), but maternal mice did not.
Title: Neurotensin induced Egr-1 activity is altered in the postpartum period in mice.
Data show that Egr1-induced activation of the Ca(V)3.2 promoter was effectively counteracted by the repressor element 1-silencing transcription factor (REST).
Title: Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST).
compensation for deficiency in Egr-1 function in leukocyte recruitment can presumably be mediated by other transcription factors; however, Egr-1 is indispensable for effective vascular cell cycle progression in arteriogenesis.
Title: Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo.
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
Title: Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.

Submit: New GeneRIF Correction See all (169)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Targeted (Reporter) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000084.1		Cdk8	BIND	PubMed	An unspecified isoform of CDK8 interacts with Egr1.
NC_000084.1	NP_031948.3	Elk1	BIND	PubMed	ELK1 interacts with Egr1.
NC_000084.1	NP_663521.1	Gtf2b	BIND	PubMed	TFIIB interacts with Egr1.
NC_000084.1	NP_783583.1	Hist4h4	BIND	PubMed	H4 interacts with Egr1.
NC_000084.1	NP_613046.1	Nelfe	BIND	PubMed	NELF interacts with Egr1.
NC_000084.1	NP_035547.1	Smarca4	BIND	PubMed	BRG1 interacts with Egr1.
NC_000084.1	NP_065239.1	Srf	BIND	PubMed	SRF interacts with Egr1.
NC_000084.1	NP_065239.1	Srf	BIND	PubMed	SRF interacts with the Egr-1 promoter.
NC_000084.1	NP_038712.1	Tbp	BIND	PubMed	TBP interacts with Egr1.
BioGRID:199404	BioGRID:199404	Egr1	BioGRID	PubMed	Two-hybrid
BioGRID:199404	BioGRID:205102	G3bp1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199404	BioGRID:201681	Nab2	BioGRID	PubMed	Two-hybrid
BioGRID:199404	BioGRID:204839	Pin1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199404	BioGRID:202186	Pitx1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199404	BioGRID:204643	Sf1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:199404	BioGRID:203414	Sp1	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
Ovarian Infertility Genes, organism-specific biosystem
Ovarian Infertility Genes
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Prion diseases, conserved biosystem (from KEGG)
Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

General gene information

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Markers

PMC303347P1 (e-PCR)
- UniSTS:272502

RH94738 (e-PCR)
- UniSTS:119985

PMC165967P1 (e-PCR)
- UniSTS:271549

PMC165967P2 (e-PCR)
- UniSTS:271550

PMC165967P3 (e-PCR)
- UniSTS:271551

PMC321436P1 (e-PCR)
- UniSTS:273106

PMC19934P2 (e-PCR)
- UniSTS:271864

Homology

Homologs of the Egr1 gene: The Egr1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	ISO Inferred from Sequence Orthology more info
RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to heparin	ISO Inferred from Sequence Orthology more info
cellular response to mycophenolic acid	ISO Inferred from Sequence Orthology more info
cellular response to organic substance	IDA Inferred from Direct Assay more info
glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
learning or memory	ISO Inferred from Sequence Orthology more info
negative regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell death	ISO Inferred from Sequence Orthology more info
positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
positive regulation of glomerular metanephric mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: early growth response protein 1

Names: early growth response protein 1; Krox-24 nuclear protein; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007913.5 → NP_031939.1 early growth response protein 1

Status: VALIDATED

Source sequence(s)

AK037837, AK040925

Consensus CDS

CCDS29136.1

UniProtKB/Swiss-Prot

P08046

UniProtKB/TrEMBL

Q544D6

UniProtKB/TrEMBL

Q8CAT6

Conserved Domains (4) summary

pfam11914
Location:476 – 499
Blast Score: 79

DUF3432; Domain of unknown function (DUF3432)

pfam11928
Location:132 – 217
Blast Score: 163

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:380 – 405
Blast Score: 113

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:338 – 360
Blast Score: 84

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000084.6 Reference GRCm38.p1 C57BL/6J

Range

34861207..34864956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000040.1 Alternate Mm_Celera

Range

35315402..35319152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01137656.1 (18956..22706)	None
genomic	AC114820.4 (82324..86073)	None
genomic	CH466557.1	EDK97120.1	mixed
genomic	M28844.1	AAB00468.1
genomic	M28845.1	AAB00468.1
genomic	X12617.1	None	BALB/c
mRNA	AK037837.1	BAC29885.1	C57BL/6J
mRNA	AK040925.1	BAC30748.1	C57BL/6J
mRNA	AK133630.1	BAE21758.1	C57BL/6J
mRNA	AK145198.1	BAE26289.1
mRNA	AK146322.1	BAE27077.1	BALB/c
mRNA	BC138613.1	AAI38614.1
mRNA	BC138615.1	AAI38616.1
mRNA	M19643.1	AAA39382.1
mRNA	M20157.1	AAA37544.1
mRNA	M22326.1	AAA40416.1
mRNA	M38174.1	AAA39383.1