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Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

Gene ID: 13649, updated on 18-May-2013

Summary

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Official Symbol: Egfrprovided by MGI
Official Full Name: epidermal growth factor receptorprovided by MGI
Primary source: MGI:95294
Locus tag: RP23-295E4.1
See related: Ensembl:ENSMUSG00000020122; Vega:OTTMUSG00000005185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wa5; wa2; Erbb; Errp; wa-2; Errb1; AI552599; 9030024J15Rik

Genomic context

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Location :: 11 A1-A4; 11 9.41 cM

Sequence :: Chromosome: 11; NC_000077.6 (16752203..16913907)

See Egfr in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggested that the Pkd1 mutation induced upregulation of HDAC6 might act to slow the trafficking of EGFR
Title: HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.
The early stages of squamous carcinoma development are driven by a change in amplitude of EGFR signalling governed by the loss of contact inhibition.
Title: LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
Title: Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.
PEPD is a ligand of EGFR and presents a novel mechanism of EGFR activation
Title: Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.
NEU3 up-regulation stimulates the EGF receptor signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha), resulting in a final increase of cell survival and proliferation.
Title: NEU3 sialidase is activated under hypoxia and protects skeletal muscle cells from apoptosis through the activation of the epidermal growth factor receptor signaling pathway and the hypoxia-inducible factor (HIF)-1α.
in cardiomyocytes, EGFR prevents hypertrophic growth through its impact on reactive oxygen species. in vascular smooth muscle cells EGFR contributes to vascular wall architecture and vessel reactivity, thereby supporting a physiological vascular tone.
Title: Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma
Title: Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma.
We provide in vivo genetic evidence that the role of ADAM17 during embryonic eyelid closure is to transactivate EGFR signaling.
Title: ADAM17 transactivates EGFR signaling during embryonic eyelid closure.
These results describe a unique role for EGFR and Met in mammary epithelial cells.
Title: Met receptor acts uniquely for survival and morphogenesis of EGFR-dependent normal mammary epithelial and cancer cells.
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model
Title: Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model.

Submit: New GeneRIF Correction See all (309)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Spontaneous (2)
Targeted (knock-out) (4) 1 citation
Targeted (Reporter) (1) 1 citation
Chemically induced (ENU) (3) 1 citation
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AAG24386.1	NP_032189.1	Grb2	BIND	PubMed	Grb2 interacts with EGFR. This interaction was modeled on a demonstrated interaction between Grb2 from mouse and EGFR from human.
AAG24386.1			BIND	PubMed	Grb2-mSos1 complex interacts with EGFR. This interaction was modeled on a demonstrated interaction between Grb2-mSos1 complex from mouse and EGFR from human.
NP_031938.1	NP_035332.1	Ptpn11	BIND	PubMed	Activated EGFR interacts with the SH2 domain of Syp. This interaction was modeled on a demonstrated interaction between EGFR from an unspecified species and Syp from mouse.
NP_031938.1	P35235	Ptpn11	BIND	PubMed	Activated EGFR interacts with the SH2 domain of Syp. This interaction was modeled on a demonstrated interaction between EGFR from human and Syp from mouse.
NP_031938.1	NP_038573.1	Ptpn6	BIND	PubMed	PTP1C interacts with activated EGFR. This interaction was modeled on a demonstrated interaction between PTP1C from mouse and EGFR from an unspecified species.
NP_031938.1	NP_035498.2	Shc1	BIND	PubMed	Shc interacts with EGFR.
NP_031938.1	XP_125779.3	Shc2	BIND	PubMed	ShcB interacts with EGFR. This interaction was modelled on a demonstrated interaction between ShcB from mouse and EGFR from human.
NP_031938.1	NP_033193.1	Shc3	BIND	PubMed	ShcC interacts with EGFR. This interaction was modelled on a demonstrated interaction between ShcC from mouse and EGFR from human.
NP_997538.1	NP_034201.1	Dok2	BIND	PubMed	Dok2 weakly interacts with homodimerized, tyrosine-phosphorylated Egfr.
BioGRID:199402	BioGRID:207566	Arhgef7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:198395	Btc	BioGRID	PubMed	Phenotypic Suppression
BioGRID:199402	BioGRID:198527	Cbl	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:199402	BioGRID:199489	Eps15	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:199496	Erbb2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:200046	Grb2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:199402	BioGRID:200857	Jak2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
	NP_034835.1	Lgals3	BIND	PubMed	EGFR interacts with Gal-3.
BioGRID:199402	BioGRID:204969	Mapk14	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:202219	Pla2g2a	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:199402	BioGRID:202337	Ppp1cc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:112649	STAT1	BioGRID	PubMed	Biochemical Activity
BioGRID:199402	BioGRID:208004	Socs5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:203491	Src	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:207726	Tyk2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199402	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Bladder cancer, organism-specific biosystem (from KEGG)
Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Bladder cancer, conserved biosystem (from KEGG)
Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
Calcium signaling pathway, organism-specific biosystem (from KEGG)
Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calcium signaling pathway, conserved biosystem (from KEGG)
Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
Dorso-ventral axis formation, organism-specific biosystem
Dorso-ventral axis formation
Dorso-ventral axis formation, conserved biosystem (from KEGG)
Dorso-ventral axis formation, conserved biosystem
Dorso-ventral axis formation
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR Transactivation by Gastrin, organism-specific biosystem (from REACTOME)
EGFR Transactivation by Gastrin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR downregulation, organism-specific biosystem (from REACTOME)
EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR interacts with phospholipase C-gamma, organism-specific biosystem (from REACTOME)
EGFR interacts with phospholipase C-gamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endometrial cancer, organism-specific biosystem (from KEGG)
Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Endometrial cancer, conserved biosystem (from KEGG)
Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
GRB2 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
GRB2 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glioma, organism-specific biosystem (from KEGG)
Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
Glioma, conserved biosystem (from KEGG)
Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Melanoma, organism-specific biosystem (from KEGG)
Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
Melanoma, conserved biosystem (from KEGG)
Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Non-small cell lung cancer, organism-specific biosystem (from KEGG)
Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Non-small cell lung cancer, conserved biosystem (from KEGG)
Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLCG1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PLCG1 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystem
Regulation of Actin Cytoskeleton
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
SHC1 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
SHC1 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by constitutively active EGFR, organism-specific biosystem (from REACTOME)
Signaling by constitutively active EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Egfr (e-PCR), detects polymorphism
- UniSTS:468001

Egfr (e-PCR), detects polymorphism
- UniSTS:226081

PMC122223P1 (e-PCR)
- UniSTS:270387

Egfr (e-PCR), detects polymorphism
- UniSTS:472898

X78987 (e-PCR)
- UniSTS:160069

X78987 (e-PCR)
- UniSTS:125855

AI552599 (e-PCR)
- UniSTS:180158

Homology

Homologs of the Egfr gene: The Egfr gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
actin filament binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
epidermal growth factor binding	ISO Inferred from Sequence Orthology more info
epidermal growth factor-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed
epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
glycoprotein binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
integrin binding	ISO Inferred from Sequence Orthology more info
kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein phosphatase binding	ISO Inferred from Sequence Orthology more info
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
receptor binding	ISO Inferred from Sequence Orthology more info
receptor signaling protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IDA Inferred from Direct Assay more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
activation of MAPKK activity	ISO Inferred from Sequence Orthology more info
astrocyte activation	ISO Inferred from Sequence Orthology more info
cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
cell proliferation	ISO Inferred from Sequence Orthology more info
cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cell-cell adhesion	ISO Inferred from Sequence Orthology more info
cerebral cortex cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular protein kinase cascade	ISO Inferred from Sequence Orthology more info
magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
morphogenesis of an epithelial fold	IMP Inferred from Mutant Phenotype more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
ovulation cycle	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of catenin import into nucleus	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S	ISO Inferred from Sequence Orthology more info
positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info
positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase B signaling cascade	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
positive regulation of vasodilation	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
response to UV-A	ISO Inferred from Sequence Orthology more info
response to calcium ion	ISO Inferred from Sequence Orthology more info
salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IDA Inferred from Direct Assay more info	PubMed
signal transduction	ISO Inferred from Sequence Orthology more info
signal transduction by phosphorylation	IEA Inferred from Electronic Annotation more info
translation	ISO Inferred from Sequence Orthology more info
transmembrane receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
apical plasma membrane	ISO Inferred from Sequence Orthology more info
basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
endocytic vesicle	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endosome	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular	IDA Inferred from Direct Assay more info	PubMed
membrane	ISO Inferred from Sequence Orthology more info
membrane raft	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epidermal growth factor receptor

Names: epidermal growth factor receptor; waved 2; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

NP_031938.1

EC 2.7.10.1

NP_997538.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007912.4 → NP_031938.1 epidermal growth factor receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK004883, AK004944

Consensus CDS

CCDS24444.1

UniProtKB/TrEMBL

Q9WVF5

Related

ENSMUSP00000099948, OTTMUSP00000005386, ENSMUST00000102884, OTTMUST00000011586

Conserved Domains (4) summary

cd00064
Location:558 – 598
Blast Score: 89

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cl00066
Location:231 – 274
Blast Score: 82

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:196 – 337
Blast Score: 353

Furin-like; Furin-like cysteine rich region

pfam01030
Location:57 – 168
Blast Score: 299

Recep_L_domain; Receptor L domain
NM_207655.2 → NP_997538.1 epidermal growth factor receptor isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AF275367, AK004883, AK163338, BQ553815, BY725722

Consensus CDS

CCDS24443.1

UniProtKB/Swiss-Prot

Q01279

UniProtKB/TrEMBL

Q3TQS6

UniProtKB/TrEMBL

Q9EP98

UniProtKB/TrEMBL

Q9WVF5

Conserved Domains (6) summary

cd00064
Location:558 – 598
Blast Score: 102

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05108
Location:706 – 1021
Blast Score: 1684

PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor

smart00219
Location:715 – 970
Blast Score: 962

TyrKc; Tyrosine kinase, catalytic domain

cl00066
Location:506 – 540
Blast Score: 81

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:196 – 337
Blast Score: 396

Furin-like; Furin-like cysteine rich region

pfam01030
Location:57 – 168
Blast Score: 307

Recep_L_domain; Receptor L domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

16752203..16913907

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

17126474..17287898

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01090988.1 (20249..99462)	None
genomic	AAHY01090989.1	None
genomic	AAHY01090990.1	None
genomic	AF125256.1	AAG43241.1	B6D2
genomic	AF275364.1	AAG28045.1	C57BL/6J
genomic	AF275365.1	AAG28045.1	C3H/101
genomic	AF275366.1	AAG28045.1
		AAG28046.1
		AAG28047.1
genomic	AF456454.1	AAL56615.1	129/Sv
genomic	AL645532.16 (2000..114635)	None
genomic	BX255277.5 (120696..169764)	None	ZRU
genomic	CH466574.1	EDL40666.1	mixed
		EDL40667.1	mixed
genomic	S50852.1	None
genomic	S50853.1	None
genomic	S50854.1	None
genomic	S50855.1	None
mRNA	AF124513.1	AAD44149.1	C57BL/6J
mRNA	AF275367.1	AAG24386.1	C57BL/6J
mRNA	AF277898.1	AAK01081.1
mRNA	AK004883.1	BAB23641.1	C57BL/6J
mRNA	AK004911.1	BAB23662.1	C57BL/6J
mRNA	AK004944.1	BAB23688.1	C57BL/6J
mRNA	AK014017.1	None	C57BL/6J
mRNA	AK033431.1	None	C57BL/6J
mRNA	AK049452.1	None	C57BL/6J
mRNA	AK134262.1	None	C57BL/6J
mRNA	AK163338.1	BAE37306.1	C57BL/6J
mRNA	BC023729.1	AAH23729.1	FVB/N
mRNA	BC030681.1	None	C57BL/6J
mRNA	BQ553815.1	None	C57BL/6
mRNA	BY725722.1	None
mRNA	L06864.1	AAA53029.1	CD-1
mRNA	U03425.1	AAA17899.1	B6C3
mRNA	X59698.1	CAA42219.1
mRNA	X78987.1	CAA55587.1	BALB/c
mRNA	Z12608.1	CAA78249.1	C3H